Home > Research > Publications & Outputs > Surface-grafted remedial hydroxyapatite nanopar...

Associated organisational unit


Text available via DOI:

View graph of relations

Surface-grafted remedial hydroxyapatite nanoparticles to avoid operational infections

Research output: Contribution to Journal/MagazineJournal articlepeer-review

  • F. Zarif
  • S. Tabassum
  • A. Jamal
  • U. Gul
  • M.A. Gilani
  • F. Sharif
  • S. Zahid
  • A. Asif
  • A.A. Chaudhry
  • I.U. Rehman
<mark>Journal publication date</mark>1/04/2019
<mark>Journal</mark>Monatshefte fur Chemie
Issue number4
Number of pages11
Pages (from-to)605-615
Publication StatusPublished
Early online date28/02/19
<mark>Original language</mark>English


Development of economical bone repair materials that can avoid bone infections is a necessity. Hydroxyapatite (HA) and grafted hydroxyapatite (g-HA) were prepared by the in situ co-precipitation method and explored for controlled delivery of moxifloxacin. It was revealed that high surface area, surface charge, and low degree of crystallinity of g-HA enhanced its electrostatic interaction with an antibiotic moxifloxacin and improved in vitro release of the drug as compared to pure HA. In vitro antibacterial activity showed that drug release from HA and g-HA was effective against Staphylococcus aureus and Escherichia coli. The biocompatibility of HA and g-HA was confirmed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay.