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Surface-grafted remedial hydroxyapatite nanoparticles to avoid operational infections

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Surface-grafted remedial hydroxyapatite nanoparticles to avoid operational infections. / Zarif, F.; Tabassum, S.; Jamal, A. et al.
In: Monatshefte fur Chemie, Vol. 150, No. 4, 01.04.2019, p. 605-615.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Zarif, F, Tabassum, S, Jamal, A, Gul, U, Gilani, MA, Sharif, F, Zahid, S, Asif, A, Chaudhry, AA & Rehman, IU 2019, 'Surface-grafted remedial hydroxyapatite nanoparticles to avoid operational infections', Monatshefte fur Chemie, vol. 150, no. 4, pp. 605-615. https://doi.org/10.1007/s00706-018-2339-z

APA

Zarif, F., Tabassum, S., Jamal, A., Gul, U., Gilani, M. A., Sharif, F., Zahid, S., Asif, A., Chaudhry, A. A., & Rehman, I. U. (2019). Surface-grafted remedial hydroxyapatite nanoparticles to avoid operational infections. Monatshefte fur Chemie, 150(4), 605-615. https://doi.org/10.1007/s00706-018-2339-z

Vancouver

Zarif F, Tabassum S, Jamal A, Gul U, Gilani MA, Sharif F et al. Surface-grafted remedial hydroxyapatite nanoparticles to avoid operational infections. Monatshefte fur Chemie. 2019 Apr 1;150(4):605-615. Epub 2019 Feb 28. doi: 10.1007/s00706-018-2339-z

Author

Zarif, F. ; Tabassum, S. ; Jamal, A. et al. / Surface-grafted remedial hydroxyapatite nanoparticles to avoid operational infections. In: Monatshefte fur Chemie. 2019 ; Vol. 150, No. 4. pp. 605-615.

Bibtex

@article{7a2f5d347c62468a9e2989315c09fd33,
title = "Surface-grafted remedial hydroxyapatite nanoparticles to avoid operational infections",
abstract = "Development of economical bone repair materials that can avoid bone infections is a necessity. Hydroxyapatite (HA) and grafted hydroxyapatite (g-HA) were prepared by the in situ co-precipitation method and explored for controlled delivery of moxifloxacin. It was revealed that high surface area, surface charge, and low degree of crystallinity of g-HA enhanced its electrostatic interaction with an antibiotic moxifloxacin and improved in vitro release of the drug as compared to pure HA. In vitro antibacterial activity showed that drug release from HA and g-HA was effective against Staphylococcus aureus and Escherichia coli. The biocompatibility of HA and g-HA was confirmed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay.",
keywords = "Ceramics, Drug delivery, Grafted hydroxyapatite, Nanochemistry, Surface",
author = "F. Zarif and S. Tabassum and A. Jamal and U. Gul and M.A. Gilani and F. Sharif and S. Zahid and A. Asif and A.A. Chaudhry and I.U. Rehman",
year = "2019",
month = apr,
day = "1",
doi = "10.1007/s00706-018-2339-z",
language = "English",
volume = "150",
pages = "605--615",
journal = "Monatshefte fur Chemie",
issn = "0026-9247",
publisher = "Springer-Verlag Wien",
number = "4",

}

RIS

TY - JOUR

T1 - Surface-grafted remedial hydroxyapatite nanoparticles to avoid operational infections

AU - Zarif, F.

AU - Tabassum, S.

AU - Jamal, A.

AU - Gul, U.

AU - Gilani, M.A.

AU - Sharif, F.

AU - Zahid, S.

AU - Asif, A.

AU - Chaudhry, A.A.

AU - Rehman, I.U.

PY - 2019/4/1

Y1 - 2019/4/1

N2 - Development of economical bone repair materials that can avoid bone infections is a necessity. Hydroxyapatite (HA) and grafted hydroxyapatite (g-HA) were prepared by the in situ co-precipitation method and explored for controlled delivery of moxifloxacin. It was revealed that high surface area, surface charge, and low degree of crystallinity of g-HA enhanced its electrostatic interaction with an antibiotic moxifloxacin and improved in vitro release of the drug as compared to pure HA. In vitro antibacterial activity showed that drug release from HA and g-HA was effective against Staphylococcus aureus and Escherichia coli. The biocompatibility of HA and g-HA was confirmed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay.

AB - Development of economical bone repair materials that can avoid bone infections is a necessity. Hydroxyapatite (HA) and grafted hydroxyapatite (g-HA) were prepared by the in situ co-precipitation method and explored for controlled delivery of moxifloxacin. It was revealed that high surface area, surface charge, and low degree of crystallinity of g-HA enhanced its electrostatic interaction with an antibiotic moxifloxacin and improved in vitro release of the drug as compared to pure HA. In vitro antibacterial activity showed that drug release from HA and g-HA was effective against Staphylococcus aureus and Escherichia coli. The biocompatibility of HA and g-HA was confirmed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay.

KW - Ceramics

KW - Drug delivery

KW - Grafted hydroxyapatite

KW - Nanochemistry

KW - Surface

U2 - 10.1007/s00706-018-2339-z

DO - 10.1007/s00706-018-2339-z

M3 - Journal article

VL - 150

SP - 605

EP - 615

JO - Monatshefte fur Chemie

JF - Monatshefte fur Chemie

SN - 0026-9247

IS - 4

ER -