Final published version
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - Survival at older ages
T2 - Are greater influenza antibody titers protective?
AU - Metcalf, C.J.E.
AU - Klein, S.L.
AU - Read, J.M.
AU - Riley, S.
AU - Cummings, D.A.T.
AU - Guan, Y.
AU - Kwok, K.O.
AU - Zhu, H.
AU - Jiang, C.
AU - Hing Lam, T.
AU - Lessler, J.
PY - 2023/9/30
Y1 - 2023/9/30
N2 - Antibodies are a core element of the immune system’s defense against infectious diseases. We hypothesize that antibody titres might therefore be an important predictor of survival in older individuals. This is important because biomarkers that robustly measure survival have proved elusive, despite their potential utility in health care settings. We present evidence supporting the hypothesis that influenza antibody titres are associated with overall survival of older individuals, and indicate a role for biological sex in modulating this association. Since antibody titres can be altered by vaccination, these results have important implications for public health policy on influenza control in aging populations.
AB - Antibodies are a core element of the immune system’s defense against infectious diseases. We hypothesize that antibody titres might therefore be an important predictor of survival in older individuals. This is important because biomarkers that robustly measure survival have proved elusive, despite their potential utility in health care settings. We present evidence supporting the hypothesis that influenza antibody titres are associated with overall survival of older individuals, and indicate a role for biological sex in modulating this association. Since antibody titres can be altered by vaccination, these results have important implications for public health policy on influenza control in aging populations.
KW - Biomarker
KW - Survival
KW - Sex difference
KW - Immunity
KW - Influenza
U2 - 10.1016/j.mehy.2023.111135
DO - 10.1016/j.mehy.2023.111135
M3 - Journal article
VL - 178
JO - Medical Hypotheses
JF - Medical Hypotheses
SN - 0306-9877
M1 - 111135
ER -