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Survival at older ages: Are greater influenza antibody titers protective?

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Survival at older ages: Are greater influenza antibody titers protective? / Metcalf, C.J.E.; Klein, S.L.; Read, J.M. et al.
In: Medical Hypotheses, Vol. 178, 111135, 30.09.2023.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Metcalf, CJE, Klein, SL, Read, JM, Riley, S, Cummings, DAT, Guan, Y, Kwok, KO, Zhu, H, Jiang, C, Hing Lam, T & Lessler, J 2023, 'Survival at older ages: Are greater influenza antibody titers protective?', Medical Hypotheses, vol. 178, 111135. https://doi.org/10.1016/j.mehy.2023.111135

APA

Metcalf, C. J. E., Klein, S. L., Read, J. M., Riley, S., Cummings, D. A. T., Guan, Y., Kwok, K. O., Zhu, H., Jiang, C., Hing Lam, T., & Lessler, J. (2023). Survival at older ages: Are greater influenza antibody titers protective? Medical Hypotheses, 178, Article 111135. https://doi.org/10.1016/j.mehy.2023.111135

Vancouver

Metcalf CJE, Klein SL, Read JM, Riley S, Cummings DAT, Guan Y et al. Survival at older ages: Are greater influenza antibody titers protective? Medical Hypotheses. 2023 Sept 30;178:111135. Epub 2023 Aug 19. doi: 10.1016/j.mehy.2023.111135

Author

Metcalf, C.J.E. ; Klein, S.L. ; Read, J.M. et al. / Survival at older ages : Are greater influenza antibody titers protective?. In: Medical Hypotheses. 2023 ; Vol. 178.

Bibtex

@article{59d374fd20f1444b8e37ba127b299acd,
title = "Survival at older ages: Are greater influenza antibody titers protective?",
abstract = "Antibodies are a core element of the immune system{\textquoteright}s defense against infectious diseases. We hypothesize that antibody titres might therefore be an important predictor of survival in older individuals. This is important because biomarkers that robustly measure survival have proved elusive, despite their potential utility in health care settings. We present evidence supporting the hypothesis that influenza antibody titres are associated with overall survival of older individuals, and indicate a role for biological sex in modulating this association. Since antibody titres can be altered by vaccination, these results have important implications for public health policy on influenza control in aging populations.",
keywords = "Biomarker, Survival, Sex difference, Immunity, Influenza",
author = "C.J.E. Metcalf and S.L. Klein and J.M. Read and S. Riley and D.A.T. Cummings and Y. Guan and K.O. Kwok and H. Zhu and C. Jiang and {Hing Lam}, T. and J. Lessler",
year = "2023",
month = sep,
day = "30",
doi = "10.1016/j.mehy.2023.111135",
language = "English",
volume = "178",
journal = "Medical Hypotheses",
issn = "0306-9877",
publisher = "Churchill Livingstone",

}

RIS

TY - JOUR

T1 - Survival at older ages

T2 - Are greater influenza antibody titers protective?

AU - Metcalf, C.J.E.

AU - Klein, S.L.

AU - Read, J.M.

AU - Riley, S.

AU - Cummings, D.A.T.

AU - Guan, Y.

AU - Kwok, K.O.

AU - Zhu, H.

AU - Jiang, C.

AU - Hing Lam, T.

AU - Lessler, J.

PY - 2023/9/30

Y1 - 2023/9/30

N2 - Antibodies are a core element of the immune system’s defense against infectious diseases. We hypothesize that antibody titres might therefore be an important predictor of survival in older individuals. This is important because biomarkers that robustly measure survival have proved elusive, despite their potential utility in health care settings. We present evidence supporting the hypothesis that influenza antibody titres are associated with overall survival of older individuals, and indicate a role for biological sex in modulating this association. Since antibody titres can be altered by vaccination, these results have important implications for public health policy on influenza control in aging populations.

AB - Antibodies are a core element of the immune system’s defense against infectious diseases. We hypothesize that antibody titres might therefore be an important predictor of survival in older individuals. This is important because biomarkers that robustly measure survival have proved elusive, despite their potential utility in health care settings. We present evidence supporting the hypothesis that influenza antibody titres are associated with overall survival of older individuals, and indicate a role for biological sex in modulating this association. Since antibody titres can be altered by vaccination, these results have important implications for public health policy on influenza control in aging populations.

KW - Biomarker

KW - Survival

KW - Sex difference

KW - Immunity

KW - Influenza

U2 - 10.1016/j.mehy.2023.111135

DO - 10.1016/j.mehy.2023.111135

M3 - Journal article

VL - 178

JO - Medical Hypotheses

JF - Medical Hypotheses

SN - 0306-9877

M1 - 111135

ER -