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Synthesis of Functionalized Isoindolinones via Calcium Catalyzed Generation and Trapping of N-Acyliminium Ions

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<mark>Journal publication date</mark>17/04/2020
<mark>Journal</mark>The Journal of Organic Chemistry
Issue number8
Number of pages14
Pages (from-to)5615-5628
Publication StatusPublished
Early online date25/03/20
<mark>Original language</mark>English


Herein we report our full investigation into the calcium catalyzed generation and trapping of N-acyliminium ions from readily available 3-hydroxyisoindolinones. We have successfully employed a range of traditional nucleophiles including carbon, nitrogen, and sulfur containing reactive partners. The reaction is tolerant to a wide range of functionalities and provides high value scaffolds in good to excellent yields.