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    Rights statement: This is the peer reviewed version of the following article: Roetker NS, Armasu SM, Pankow JS, Lutsey PL, Tang W, Rosenberg MA, Palmer TM, MacLehose RF, Heckbert SR, Cushman M, de Andrade M, Folsom AR. Taller height as a risk factor for venous thromboembolism: a Mendelian randomization meta-analysis. J Thromb Haemost 2017; 15: 1334–43. which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1111/jth.13719/abstract This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.

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Taller height as a risk factor for venous thromboembolism: a Mendelian randomization meta-analysis

Research output: Contribution to journalJournal articlepeer-review

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  • Nicholas Roetker
  • S. M. Armasu
  • J. S. Pankow
  • P. L. Lutsey
  • W. Tang
  • M. A. Rosenberg
  • Thomas Michael Palmer
  • R. F. MacLehose
  • S. R. Heckbert
  • M. Cushman
  • M. de Andrade
  • A. R. Folsom
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<mark>Journal publication date</mark>07/2017
<mark>Journal</mark>Journal of Thrombosis and Haemostasis
Issue number7
Volume15
Number of pages10
Pages (from-to)1334-1343
Publication StatusPublished
Early online date6/06/17
<mark>Original language</mark>English

Abstract

Background

Taller height is associated with greater risk of venous thromboembolism (VTE).

Objectives

We used instrumental variable (IV) techniques (Mendelian randomization) to further explore this relationship

Methods

Participants of European ancestry were included from two cohort studies [Atherosclerosis Risk in Communities (ARIC) study and Cardiovascular Health Study (CHS)] and one case-control study [Mayo Clinic VTE Study (Mayo)]. We created two weighted genetic risk scores (GRS) for height; the full GRS included 668 single nucleotide polymorphisms (SNPs) from a previously published meta-analysis and the restricted GRS included a subset of 362 SNPs not associated with weight independently of height. Standard logistic regression and IV models were used to estimate odds ratios (ORs) for VTE per 10 cm increment in height. ORs were pooled across the three studies using inverse variance weighted random effects meta-analysis

Results

Among 9143 ARIC and 3180 CHS participants free of VTE at baseline, there were 367 and 109 incident VTE events. There were 1143 VTE cases and 1292 controls included from Mayo. The pooled ORs from non-IV models and models using the full and restricted GRSs as IVs were 1.27 (95% CI: 1.11, 1.46), 1.34 (95% CI: 1.04, 1.73), and 1.45 (95% CI: 1.04, 2.01) per 10 cm greater height, respectively.

Conclusions

Taller height is associated with an increased risk of VTE in adults of European ancestry. Possible explanations for this association, including that taller people may have greater venous surface area, greater number of venous valves, or greater hydrostatic pressure, need to be explored further.

Bibliographic note

This is the peer reviewed version of the following article: Roetker NS, Armasu SM, Pankow JS, Lutsey PL, Tang W, Rosenberg MA, Palmer TM, MacLehose RF, Heckbert SR, Cushman M, de Andrade M, Folsom AR. Taller height as a risk factor for venous thromboembolism: a Mendelian randomization meta-analysis. J Thromb Haemost 2017; 15: 1334–43. which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1111/jth.13719/abstract This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.