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Targeted elimination of mesenchymal-like cancer cells through cyclic stretch activation of Piezo1 channels: the physical aspects

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Targeted elimination of mesenchymal-like cancer cells through cyclic stretch activation of Piezo1 channels: the physical aspects. / Pajic-Lijakovic, I.; Milivojevic, M.; Martinac, B. et al.
In: Biophysical Reviews, Vol. 17, No. 3, 30.06.2025, p. 847-865.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

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Pajic-Lijakovic I, Milivojevic M, Martinac B, McClintock PVE. Targeted elimination of mesenchymal-like cancer cells through cyclic stretch activation of Piezo1 channels: the physical aspects. Biophysical Reviews. 2025 Jun 30;17(3):847-865. Epub 2025 Mar 19. doi: 10.1007/s12551-025-01304-y

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Pajic-Lijakovic, I. ; Milivojevic, M. ; Martinac, B. et al. / Targeted elimination of mesenchymal-like cancer cells through cyclic stretch activation of Piezo1 channels : the physical aspects. In: Biophysical Reviews. 2025 ; Vol. 17, No. 3. pp. 847-865.

Bibtex

@article{8005e84f1e764e7fab7a555444ec7f08,
title = "Targeted elimination of mesenchymal-like cancer cells through cyclic stretch activation of Piezo1 channels: the physical aspects",
abstract = "The application of cyclic stretch could represent a novel therapeutic method for fighting cancer. Research indicates that this mechanical stimulus selectively induces cell death in cancer mesenchymal-like cells while enhancing the migration and proliferation of healthy epithelial cells. Although the mechanisms have been examined through the lenses of cell signalling, gene expression, and biochemical processes, a significant gap persists in our understanding of the physical factors that drive cellular responses. This study aims to clarify the importance of physical factors, particularly the viscoelastic characteristics of the cell membrane, including actin cytoskeleton and lipid bilayer, and how their coupling affects bilayer bending and activation of the mechanosensitive Piezo1 channels in response to cyclic stretch in both epithelial and cancer cells. The bending of the bilayer surrounding Piezo1 molecules affects their conformations, which in turn influences calcium influx. This bending is contingent upon the coupling between the cell membrane and extracellular matrix. The primary factors contributing to the mechanically induced apoptosis of cancer cells are the perturbation of intracellular calcium homeostasis and disruption of focal adhesions.",
author = "I. Pajic-Lijakovic and M. Milivojevic and B. Martinac and P.V.E. McClintock",
year = "2025",
month = jun,
day = "30",
doi = "10.1007/s12551-025-01304-y",
language = "English",
volume = "17",
pages = "847--865",
journal = "Biophysical Reviews",
publisher = "Springer",
number = "3",

}

RIS

TY - JOUR

T1 - Targeted elimination of mesenchymal-like cancer cells through cyclic stretch activation of Piezo1 channels

T2 - the physical aspects

AU - Pajic-Lijakovic, I.

AU - Milivojevic, M.

AU - Martinac, B.

AU - McClintock, P.V.E.

PY - 2025/6/30

Y1 - 2025/6/30

N2 - The application of cyclic stretch could represent a novel therapeutic method for fighting cancer. Research indicates that this mechanical stimulus selectively induces cell death in cancer mesenchymal-like cells while enhancing the migration and proliferation of healthy epithelial cells. Although the mechanisms have been examined through the lenses of cell signalling, gene expression, and biochemical processes, a significant gap persists in our understanding of the physical factors that drive cellular responses. This study aims to clarify the importance of physical factors, particularly the viscoelastic characteristics of the cell membrane, including actin cytoskeleton and lipid bilayer, and how their coupling affects bilayer bending and activation of the mechanosensitive Piezo1 channels in response to cyclic stretch in both epithelial and cancer cells. The bending of the bilayer surrounding Piezo1 molecules affects their conformations, which in turn influences calcium influx. This bending is contingent upon the coupling between the cell membrane and extracellular matrix. The primary factors contributing to the mechanically induced apoptosis of cancer cells are the perturbation of intracellular calcium homeostasis and disruption of focal adhesions.

AB - The application of cyclic stretch could represent a novel therapeutic method for fighting cancer. Research indicates that this mechanical stimulus selectively induces cell death in cancer mesenchymal-like cells while enhancing the migration and proliferation of healthy epithelial cells. Although the mechanisms have been examined through the lenses of cell signalling, gene expression, and biochemical processes, a significant gap persists in our understanding of the physical factors that drive cellular responses. This study aims to clarify the importance of physical factors, particularly the viscoelastic characteristics of the cell membrane, including actin cytoskeleton and lipid bilayer, and how their coupling affects bilayer bending and activation of the mechanosensitive Piezo1 channels in response to cyclic stretch in both epithelial and cancer cells. The bending of the bilayer surrounding Piezo1 molecules affects their conformations, which in turn influences calcium influx. This bending is contingent upon the coupling between the cell membrane and extracellular matrix. The primary factors contributing to the mechanically induced apoptosis of cancer cells are the perturbation of intracellular calcium homeostasis and disruption of focal adhesions.

U2 - 10.1007/s12551-025-01304-y

DO - 10.1007/s12551-025-01304-y

M3 - Journal article

VL - 17

SP - 847

EP - 865

JO - Biophysical Reviews

JF - Biophysical Reviews

IS - 3

ER -