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The cerebrovascular basement membrane: Role in the clearance of β-amyloid and cerebral amyloid angiopathy

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The cerebrovascular basement membrane : Role in the clearance of β-amyloid and cerebral amyloid angiopathy. / Morris, Alan W.J.; Carare, Roxana O.; Schreiber, Stefanie; Hawkes, Cheryl A.

In: Frontiers in Aging Neuroscience, Vol. 6, No. SEP, 251, 01.09.2014.

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Morris, Alan W.J. ; Carare, Roxana O. ; Schreiber, Stefanie ; Hawkes, Cheryl A. / The cerebrovascular basement membrane : Role in the clearance of β-amyloid and cerebral amyloid angiopathy. In: Frontiers in Aging Neuroscience. 2014 ; Vol. 6, No. SEP.

Bibtex

@article{1c0a9e07dc204430b84be3120d2b166d,
title = "The cerebrovascular basement membrane: Role in the clearance of β-amyloid and cerebral amyloid angiopathy",
abstract = "Cerebral amyloid angiopathy (CAA), the accumulation of β-amyloid (Aβ) peptides in the walls of cerebral blood vessels, is observed in the majority of Alzheimer's disease (AD) brains and is thought to be due to a failure of the aging brain to clear Aβ. Perivascular drainage of Aβ along cerebrovascular basement membranes (CVBMs) is one of the mechanisms by which Aβ is removed from the brain. CVBMs are specialized sheets of extracellular matrix that provide structural and functional support for cerebral blood vessels. Changes in CVBM composition and structure are observed in the aged and AD brain and may contribute to the development and progression of CAA. This review summarizes the properties of the CVBM, its role in mediating clearance of interstitial fluids and solutes from the brain, and evidence supporting a role for CVBM in the etiology of CAA.",
keywords = "Alzheimer's disease, Basement membrane, Cerebral amyloid angiopathy, Perivascular drainage, β-amyloid",
author = "Morris, {Alan W.J.} and Carare, {Roxana O.} and Stefanie Schreiber and Hawkes, {Cheryl A.}",
year = "2014",
month = sep,
day = "1",
doi = "10.3389/fnagi.2014.00251",
language = "English",
volume = "6",
journal = "Frontiers in Aging Neuroscience",
issn = "1663-4365",
publisher = "Frontiers Media S.A.",
number = "SEP",

}

RIS

TY - JOUR

T1 - The cerebrovascular basement membrane

T2 - Role in the clearance of β-amyloid and cerebral amyloid angiopathy

AU - Morris, Alan W.J.

AU - Carare, Roxana O.

AU - Schreiber, Stefanie

AU - Hawkes, Cheryl A.

PY - 2014/9/1

Y1 - 2014/9/1

N2 - Cerebral amyloid angiopathy (CAA), the accumulation of β-amyloid (Aβ) peptides in the walls of cerebral blood vessels, is observed in the majority of Alzheimer's disease (AD) brains and is thought to be due to a failure of the aging brain to clear Aβ. Perivascular drainage of Aβ along cerebrovascular basement membranes (CVBMs) is one of the mechanisms by which Aβ is removed from the brain. CVBMs are specialized sheets of extracellular matrix that provide structural and functional support for cerebral blood vessels. Changes in CVBM composition and structure are observed in the aged and AD brain and may contribute to the development and progression of CAA. This review summarizes the properties of the CVBM, its role in mediating clearance of interstitial fluids and solutes from the brain, and evidence supporting a role for CVBM in the etiology of CAA.

AB - Cerebral amyloid angiopathy (CAA), the accumulation of β-amyloid (Aβ) peptides in the walls of cerebral blood vessels, is observed in the majority of Alzheimer's disease (AD) brains and is thought to be due to a failure of the aging brain to clear Aβ. Perivascular drainage of Aβ along cerebrovascular basement membranes (CVBMs) is one of the mechanisms by which Aβ is removed from the brain. CVBMs are specialized sheets of extracellular matrix that provide structural and functional support for cerebral blood vessels. Changes in CVBM composition and structure are observed in the aged and AD brain and may contribute to the development and progression of CAA. This review summarizes the properties of the CVBM, its role in mediating clearance of interstitial fluids and solutes from the brain, and evidence supporting a role for CVBM in the etiology of CAA.

KW - Alzheimer's disease

KW - Basement membrane

KW - Cerebral amyloid angiopathy

KW - Perivascular drainage

KW - β-amyloid

U2 - 10.3389/fnagi.2014.00251

DO - 10.3389/fnagi.2014.00251

M3 - Review article

AN - SCOPUS:84907222721

VL - 6

JO - Frontiers in Aging Neuroscience

JF - Frontiers in Aging Neuroscience

SN - 1663-4365

IS - SEP

M1 - 251

ER -