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The effect of selective decontamination of the digestive tract on mortality in multiple trauma patients: a multicenter randomized controlled trial.

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Standard

The effect of selective decontamination of the digestive tract on mortality in multiple trauma patients : a multicenter randomized controlled trial. / The Working Group on Selective Decontamination of the Digestive Tract.

In: Intensive Care Medicine, Vol. 33, No. 2, 02.2007, p. 261-270.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

The Working Group on Selective Decontamination of the Digestive Tract 2007, 'The effect of selective decontamination of the digestive tract on mortality in multiple trauma patients: a multicenter randomized controlled trial.', Intensive Care Medicine, vol. 33, no. 2, pp. 261-270. https://doi.org/10.1007/s00134-006-0455-4

APA

Vancouver

The Working Group on Selective Decontamination of the Digestive Tract. The effect of selective decontamination of the digestive tract on mortality in multiple trauma patients: a multicenter randomized controlled trial. Intensive Care Medicine. 2007 Feb;33(2):261-270. doi: 10.1007/s00134-006-0455-4

Author

The Working Group on Selective Decontamination of the Digestive Tract. / The effect of selective decontamination of the digestive tract on mortality in multiple trauma patients : a multicenter randomized controlled trial. In: Intensive Care Medicine. 2007 ; Vol. 33, No. 2. pp. 261-270.

Bibtex

@article{ed0e868fcd7a480e865472919f8837ca,
title = "The effect of selective decontamination of the digestive tract on mortality in multiple trauma patients: a multicenter randomized controlled trial.",
abstract = "Objective Evaluation of selective decontamination of the digestive tract (SDD) on late mortality in ventilated trauma patients in an intensive care unit (ICU).Methods A multicenter, randomized controlled trial was undertaken in 401 trauma patients with Hospital Trauma Index-Injury Severity Score of 16 or higher. Patients were randomized to control (n = 200) or SDD (n = 201), using polymyxin E, tobramycin, and amphotericin B in throat and gut throughout ICU treatment combined with cefotaxime for 4 days. Primary endpoint was late mortality excluding early death from hemorrhage or craniocerebral injury. Secondary endpoints were infection and organ dysfunction.Results Mortality was 20.9% with SDD and 22.0% in controls. Overall late mortality was 15.3% (57/372) as 29 patients died from cerebral injury, 16 SDD and 13 control. The odds ratio (95% confidence intervals) of late mortality for SDD relative to control was 0.75 (0.40–1.37), corresponding to estimates of 13.4% SDD and 17.2% control. The overall infection rate was reduced in the test group (48.8% vs. 61.0%). SDD reduced lower airway infections (30.9% vs. 50.0%) and bloodstream infections due to aerobic Gram-negative bacilli (2.5% vs. 7.5%). No difference in organ dysfunction was found.Conclusion This study demonstrates that SDD significantly reduces infection in multiple trauma, although this RCT in 401 patients was underpowered to detect a mortality benefit.",
author = "Chris Stoutenbeek and {van Saene}, Hendrik and Rod Little and Anne Whitehead and {The Working Group on Selective Decontamination of the Digestive Tract}",
year = "2007",
month = feb,
doi = "10.1007/s00134-006-0455-4",
language = "English",
volume = "33",
pages = "261--270",
journal = "Intensive Care Medicine",
issn = "0342-4642",
publisher = "Springer Verlag",
number = "2",

}

RIS

TY - JOUR

T1 - The effect of selective decontamination of the digestive tract on mortality in multiple trauma patients

T2 - a multicenter randomized controlled trial.

AU - Stoutenbeek, Chris

AU - van Saene, Hendrik

AU - Little, Rod

AU - Whitehead, Anne

AU - The Working Group on Selective Decontamination of the Digestive Tract

PY - 2007/2

Y1 - 2007/2

N2 - Objective Evaluation of selective decontamination of the digestive tract (SDD) on late mortality in ventilated trauma patients in an intensive care unit (ICU).Methods A multicenter, randomized controlled trial was undertaken in 401 trauma patients with Hospital Trauma Index-Injury Severity Score of 16 or higher. Patients were randomized to control (n = 200) or SDD (n = 201), using polymyxin E, tobramycin, and amphotericin B in throat and gut throughout ICU treatment combined with cefotaxime for 4 days. Primary endpoint was late mortality excluding early death from hemorrhage or craniocerebral injury. Secondary endpoints were infection and organ dysfunction.Results Mortality was 20.9% with SDD and 22.0% in controls. Overall late mortality was 15.3% (57/372) as 29 patients died from cerebral injury, 16 SDD and 13 control. The odds ratio (95% confidence intervals) of late mortality for SDD relative to control was 0.75 (0.40–1.37), corresponding to estimates of 13.4% SDD and 17.2% control. The overall infection rate was reduced in the test group (48.8% vs. 61.0%). SDD reduced lower airway infections (30.9% vs. 50.0%) and bloodstream infections due to aerobic Gram-negative bacilli (2.5% vs. 7.5%). No difference in organ dysfunction was found.Conclusion This study demonstrates that SDD significantly reduces infection in multiple trauma, although this RCT in 401 patients was underpowered to detect a mortality benefit.

AB - Objective Evaluation of selective decontamination of the digestive tract (SDD) on late mortality in ventilated trauma patients in an intensive care unit (ICU).Methods A multicenter, randomized controlled trial was undertaken in 401 trauma patients with Hospital Trauma Index-Injury Severity Score of 16 or higher. Patients were randomized to control (n = 200) or SDD (n = 201), using polymyxin E, tobramycin, and amphotericin B in throat and gut throughout ICU treatment combined with cefotaxime for 4 days. Primary endpoint was late mortality excluding early death from hemorrhage or craniocerebral injury. Secondary endpoints were infection and organ dysfunction.Results Mortality was 20.9% with SDD and 22.0% in controls. Overall late mortality was 15.3% (57/372) as 29 patients died from cerebral injury, 16 SDD and 13 control. The odds ratio (95% confidence intervals) of late mortality for SDD relative to control was 0.75 (0.40–1.37), corresponding to estimates of 13.4% SDD and 17.2% control. The overall infection rate was reduced in the test group (48.8% vs. 61.0%). SDD reduced lower airway infections (30.9% vs. 50.0%) and bloodstream infections due to aerobic Gram-negative bacilli (2.5% vs. 7.5%). No difference in organ dysfunction was found.Conclusion This study demonstrates that SDD significantly reduces infection in multiple trauma, although this RCT in 401 patients was underpowered to detect a mortality benefit.

U2 - 10.1007/s00134-006-0455-4

DO - 10.1007/s00134-006-0455-4

M3 - Journal article

VL - 33

SP - 261

EP - 270

JO - Intensive Care Medicine

JF - Intensive Care Medicine

SN - 0342-4642

IS - 2

ER -