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The evolution of lithium therapy.

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The evolution of lithium therapy. / Johnson, F. N.
In: Journal of Psychopharmacology, Vol. 6, No. 2, 1992, p. 325-329.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Johnson, FN 1992, 'The evolution of lithium therapy.', Journal of Psychopharmacology, vol. 6, no. 2, pp. 325-329. https://doi.org/10.1177/0269881192006002071

APA

Johnson, F. N. (1992). The evolution of lithium therapy. Journal of Psychopharmacology, 6(2), 325-329. https://doi.org/10.1177/0269881192006002071

Vancouver

Johnson FN. The evolution of lithium therapy. Journal of Psychopharmacology. 1992;6(2):325-329. doi: 10.1177/0269881192006002071

Author

Johnson, F. N. / The evolution of lithium therapy. In: Journal of Psychopharmacology. 1992 ; Vol. 6, No. 2. pp. 325-329.

Bibtex

@article{97d458393b124926bfb20f8978926ed0,
title = "The evolution of lithium therapy.",
abstract = "The evolution of lithium therapy for the treatment of mania and depression, from its discovery to the present day, is described. Early problems with toxicity have been overcome and lithium is now established as a safe medication, provided serum levels are monitored. The mechanism of action of lithium is not yet known, but biochemical models are beginning to be put forward. Lower doses of lithium than were previously used are now recommended. Treatment with intermittent doses of lithium (every second day) seems to reduce side effects, while maintaining clinical efficacy. Lithium has recently been used in combination with other medications. Augmentation of unsuccessful antidepressant treatment with lithium may produce an antidepressant effect within a short time. Withdrawal from lithium therapy usually results in a relapse. Lithium treatment is also used outside psychiatry. Other potential clinical applications for lithium therapy are discussed.",
keywords = "lithium • mania • depression • toxicity • lithium augmentation • withdrawal",
author = "Johnson, {F. N.}",
year = "1992",
doi = "10.1177/0269881192006002071",
language = "English",
volume = "6",
pages = "325--329",
journal = "Journal of Psychopharmacology",
issn = "1461-7285",
publisher = "SAGE Publications Ltd",
number = "2",

}

RIS

TY - JOUR

T1 - The evolution of lithium therapy.

AU - Johnson, F. N.

PY - 1992

Y1 - 1992

N2 - The evolution of lithium therapy for the treatment of mania and depression, from its discovery to the present day, is described. Early problems with toxicity have been overcome and lithium is now established as a safe medication, provided serum levels are monitored. The mechanism of action of lithium is not yet known, but biochemical models are beginning to be put forward. Lower doses of lithium than were previously used are now recommended. Treatment with intermittent doses of lithium (every second day) seems to reduce side effects, while maintaining clinical efficacy. Lithium has recently been used in combination with other medications. Augmentation of unsuccessful antidepressant treatment with lithium may produce an antidepressant effect within a short time. Withdrawal from lithium therapy usually results in a relapse. Lithium treatment is also used outside psychiatry. Other potential clinical applications for lithium therapy are discussed.

AB - The evolution of lithium therapy for the treatment of mania and depression, from its discovery to the present day, is described. Early problems with toxicity have been overcome and lithium is now established as a safe medication, provided serum levels are monitored. The mechanism of action of lithium is not yet known, but biochemical models are beginning to be put forward. Lower doses of lithium than were previously used are now recommended. Treatment with intermittent doses of lithium (every second day) seems to reduce side effects, while maintaining clinical efficacy. Lithium has recently been used in combination with other medications. Augmentation of unsuccessful antidepressant treatment with lithium may produce an antidepressant effect within a short time. Withdrawal from lithium therapy usually results in a relapse. Lithium treatment is also used outside psychiatry. Other potential clinical applications for lithium therapy are discussed.

KW - lithium • mania • depression • toxicity • lithium augmentation • withdrawal

U2 - 10.1177/0269881192006002071

DO - 10.1177/0269881192006002071

M3 - Journal article

VL - 6

SP - 325

EP - 329

JO - Journal of Psychopharmacology

JF - Journal of Psychopharmacology

SN - 1461-7285

IS - 2

ER -