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The first identification of nesfatin-1-expressing neurons in the human bed nucleus of the stria terminalis

Research output: Contribution to Journal/MagazineJournal articlepeer-review

E-pub ahead of print
  • Artur Pałasz
  • Katarzyna Bogus
  • Aleksandra Suszka-Świtek
  • Andrzej Kaśkosz
  • Shirley Saint-Remy
  • Aneta Piwowarczyk-Nowak
  • Łukasz Filipczyk
  • John Joseph Worthington
  • Kinga Mordecka-Chamera
  • Karol Kostro
  • Grzegorz Bajor
  • Ryszard Wiaderkiewicz
<mark>Journal publication date</mark>15/02/2019
<mark>Journal</mark>Journal of Neural Transmission
Number of pages7
Publication StatusE-pub ahead of print
Early online date15/02/19
<mark>Original language</mark>English


Neuropeptides are involved in various brain activities being able to control a wide spectrum of higher mental functions.
The purpose of this concise structural investigation was to detect the possible immunoreactivity of the novel multifunctional neuropeptide nesfatin-1 within the human bed nucleus of the stria terminalis (BNST). The BNST is involved in the
mechanism of fear learning, integration of stress and reward circuits, and pathogenesis of addiction. Nesfatin-1-expressing
neurons were identified for the first time in several regions of the BNST using both immunohistochemical and fluorescent
methods. This may implicate a potential contribution of this neuropeptide to the BNST-related mechanisms of stress/reward
responses in the human brain.