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The genetics of the repair of 5-azacytidine-mediated DNA damage in the fission yeast Schizosaccharomyces pombe.

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The genetics of the repair of 5-azacytidine-mediated DNA damage in the fission yeast Schizosaccharomyces pombe. / Hegde, V.; McFarlane, R.J.; Taylor, Elaine M. et al.
In: Molecular and General Genetics, Vol. 251, No. 4, 06.1996, p. 483-492.

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Hegde V, McFarlane RJ, Taylor EM, Price C. The genetics of the repair of 5-azacytidine-mediated DNA damage in the fission yeast Schizosaccharomyces pombe. Molecular and General Genetics. 1996 Jun;251(4):483-492. doi: 10.1007/BF02172377

Author

Hegde, V. ; McFarlane, R.J. ; Taylor, Elaine M. et al. / The genetics of the repair of 5-azacytidine-mediated DNA damage in the fission yeast Schizosaccharomyces pombe. In: Molecular and General Genetics. 1996 ; Vol. 251, No. 4. pp. 483-492.

Bibtex

@article{b39a6abd1e7048459e986924e510fc8b,
title = "The genetics of the repair of 5-azacytidine-mediated DNA damage in the fission yeast Schizosaccharomyces pombe.",
abstract = "We have recently demonstrated thatSchizosaccharomyces pombe cells treated with the nucleoside analogue 5-azacytidine (5-azaC) require previously characterised G2 checkpoint mechanisms for survival. Here we present a survey of known DNA repair mutations which defines those genes required for survival in the presence of 5-azaC. Using a combination of single-mutant and epistasis analyses we find that the excision, mismatch and recombinational repair pathways are all required in some degree for the repair of 5-azaC-mediated DNA damage. There are distinct differences in the epistatic interactions of several of the repair mutations with respect to 5-azaC-mediated DNA damage relative to UV-mediated DNA damage.",
keywords = "5-Azacytidine, Fission yeast, DNA repair",
author = "V. Hegde and R.J. McFarlane and Taylor, {Elaine M.} and Clive Price",
year = "1996",
month = jun,
doi = "10.1007/BF02172377",
language = "English",
volume = "251",
pages = "483--492",
journal = "Molecular and General Genetics",
issn = "1432-1874",
publisher = "Springer Verlag",
number = "4",

}

RIS

TY - JOUR

T1 - The genetics of the repair of 5-azacytidine-mediated DNA damage in the fission yeast Schizosaccharomyces pombe.

AU - Hegde, V.

AU - McFarlane, R.J.

AU - Taylor, Elaine M.

AU - Price, Clive

PY - 1996/6

Y1 - 1996/6

N2 - We have recently demonstrated thatSchizosaccharomyces pombe cells treated with the nucleoside analogue 5-azacytidine (5-azaC) require previously characterised G2 checkpoint mechanisms for survival. Here we present a survey of known DNA repair mutations which defines those genes required for survival in the presence of 5-azaC. Using a combination of single-mutant and epistasis analyses we find that the excision, mismatch and recombinational repair pathways are all required in some degree for the repair of 5-azaC-mediated DNA damage. There are distinct differences in the epistatic interactions of several of the repair mutations with respect to 5-azaC-mediated DNA damage relative to UV-mediated DNA damage.

AB - We have recently demonstrated thatSchizosaccharomyces pombe cells treated with the nucleoside analogue 5-azacytidine (5-azaC) require previously characterised G2 checkpoint mechanisms for survival. Here we present a survey of known DNA repair mutations which defines those genes required for survival in the presence of 5-azaC. Using a combination of single-mutant and epistasis analyses we find that the excision, mismatch and recombinational repair pathways are all required in some degree for the repair of 5-azaC-mediated DNA damage. There are distinct differences in the epistatic interactions of several of the repair mutations with respect to 5-azaC-mediated DNA damage relative to UV-mediated DNA damage.

KW - 5-Azacytidine

KW - Fission yeast

KW - DNA repair

U2 - 10.1007/BF02172377

DO - 10.1007/BF02172377

M3 - Journal article

VL - 251

SP - 483

EP - 492

JO - Molecular and General Genetics

JF - Molecular and General Genetics

SN - 1432-1874

IS - 4

ER -