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The impact of bed rest on human skeletal muscle metabolism

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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The impact of bed rest on human skeletal muscle metabolism. / Eggelbusch, M.; Charlton, B.T.; Bosutti, A. et al.
In: Cell Reports Medicine, Vol. 5, No. 1, 101372, 16.01.2024.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Eggelbusch, M, Charlton, BT, Bosutti, A, Ganse, B, Giakoumaki, I, Grootemaat, AE, Hendrickse, PW, Jaspers, Y, Kemp, S, Kerkhoff, TJ, Noort, W, van Weeghel, M, van der Wel, NN, Wesseling, JR, Frings-Meuthen, P, Rittweger, J, Mulder, ER, Jaspers, RT, Degens, H & Wüst, RCI 2024, 'The impact of bed rest on human skeletal muscle metabolism', Cell Reports Medicine, vol. 5, no. 1, 101372. https://doi.org/10.1016/j.xcrm.2023.101372

APA

Eggelbusch, M., Charlton, B. T., Bosutti, A., Ganse, B., Giakoumaki, I., Grootemaat, A. E., Hendrickse, P. W., Jaspers, Y., Kemp, S., Kerkhoff, T. J., Noort, W., van Weeghel, M., van der Wel, N. N., Wesseling, J. R., Frings-Meuthen, P., Rittweger, J., Mulder, E. R., Jaspers, R. T., Degens, H., & Wüst, R. C. I. (2024). The impact of bed rest on human skeletal muscle metabolism. Cell Reports Medicine, 5(1), Article 101372. https://doi.org/10.1016/j.xcrm.2023.101372

Vancouver

Eggelbusch M, Charlton BT, Bosutti A, Ganse B, Giakoumaki I, Grootemaat AE et al. The impact of bed rest on human skeletal muscle metabolism. Cell Reports Medicine. 2024 Jan 16;5(1):101372. doi: 10.1016/j.xcrm.2023.101372

Author

Eggelbusch, M. ; Charlton, B.T. ; Bosutti, A. et al. / The impact of bed rest on human skeletal muscle metabolism. In: Cell Reports Medicine. 2024 ; Vol. 5, No. 1.

Bibtex

@article{ff9fac32c4394a8f8813bd19ff2cd6ab,
title = "The impact of bed rest on human skeletal muscle metabolism",
abstract = "Insulin sensitivity and metabolic flexibility decrease in response to bed rest, but the temporal and causal adaptations in human skeletal muscle metabolism are not fully defined. Here, we use an integrative approach to assess human skeletal muscle metabolism during bed rest and provide a multi-system analysis of how skeletal muscle and the circulatory system adapt to short- and long-term bed rest (German Clinical Trials: DRKS00015677). We uncover that intracellular glycogen accumulation after short-term bed rest accompanies a rapid reduction in systemic insulin sensitivity and less GLUT4 localization at the muscle cell membrane, preventing further intracellular glycogen deposition after long-term bed rest. We provide evidence of a temporal link between the accumulation of intracellular triglycerides, lipotoxic ceramides, and sphingomyelins and an altered skeletal muscle mitochondrial structure and function after long-term bed rest. An intracellular nutrient overload therefore represents a crucial determinant for rapid skeletal muscle insulin insensitivity and mitochondrial alterations after prolonged bed rest.",
keywords = "bed rest, skeletal muscle, nutrient overload, insulin sensitivity, mitochondria, physical inactivity, metabolism, GLUT4, lipotoxicity",
author = "M. Eggelbusch and B.T. Charlton and A. Bosutti and B. Ganse and I. Giakoumaki and A.E. Grootemaat and P.W. Hendrickse and Y. Jaspers and S. Kemp and T.J. Kerkhoff and W. Noort and {van Weeghel}, M. and {van der Wel}, N.N. and J.R. Wesseling and P. Frings-Meuthen and J. Rittweger and E.R. Mulder and R.T. Jaspers and H. Degens and R.C.I. W{\"u}st",
year = "2024",
month = jan,
day = "16",
doi = "10.1016/j.xcrm.2023.101372",
language = "English",
volume = "5",
journal = "Cell Reports Medicine",
number = "1",

}

RIS

TY - JOUR

T1 - The impact of bed rest on human skeletal muscle metabolism

AU - Eggelbusch, M.

AU - Charlton, B.T.

AU - Bosutti, A.

AU - Ganse, B.

AU - Giakoumaki, I.

AU - Grootemaat, A.E.

AU - Hendrickse, P.W.

AU - Jaspers, Y.

AU - Kemp, S.

AU - Kerkhoff, T.J.

AU - Noort, W.

AU - van Weeghel, M.

AU - van der Wel, N.N.

AU - Wesseling, J.R.

AU - Frings-Meuthen, P.

AU - Rittweger, J.

AU - Mulder, E.R.

AU - Jaspers, R.T.

AU - Degens, H.

AU - Wüst, R.C.I.

PY - 2024/1/16

Y1 - 2024/1/16

N2 - Insulin sensitivity and metabolic flexibility decrease in response to bed rest, but the temporal and causal adaptations in human skeletal muscle metabolism are not fully defined. Here, we use an integrative approach to assess human skeletal muscle metabolism during bed rest and provide a multi-system analysis of how skeletal muscle and the circulatory system adapt to short- and long-term bed rest (German Clinical Trials: DRKS00015677). We uncover that intracellular glycogen accumulation after short-term bed rest accompanies a rapid reduction in systemic insulin sensitivity and less GLUT4 localization at the muscle cell membrane, preventing further intracellular glycogen deposition after long-term bed rest. We provide evidence of a temporal link between the accumulation of intracellular triglycerides, lipotoxic ceramides, and sphingomyelins and an altered skeletal muscle mitochondrial structure and function after long-term bed rest. An intracellular nutrient overload therefore represents a crucial determinant for rapid skeletal muscle insulin insensitivity and mitochondrial alterations after prolonged bed rest.

AB - Insulin sensitivity and metabolic flexibility decrease in response to bed rest, but the temporal and causal adaptations in human skeletal muscle metabolism are not fully defined. Here, we use an integrative approach to assess human skeletal muscle metabolism during bed rest and provide a multi-system analysis of how skeletal muscle and the circulatory system adapt to short- and long-term bed rest (German Clinical Trials: DRKS00015677). We uncover that intracellular glycogen accumulation after short-term bed rest accompanies a rapid reduction in systemic insulin sensitivity and less GLUT4 localization at the muscle cell membrane, preventing further intracellular glycogen deposition after long-term bed rest. We provide evidence of a temporal link between the accumulation of intracellular triglycerides, lipotoxic ceramides, and sphingomyelins and an altered skeletal muscle mitochondrial structure and function after long-term bed rest. An intracellular nutrient overload therefore represents a crucial determinant for rapid skeletal muscle insulin insensitivity and mitochondrial alterations after prolonged bed rest.

KW - bed rest

KW - skeletal muscle

KW - nutrient overload

KW - insulin sensitivity

KW - mitochondria

KW - physical inactivity

KW - metabolism

KW - GLUT4

KW - lipotoxicity

U2 - 10.1016/j.xcrm.2023.101372

DO - 10.1016/j.xcrm.2023.101372

M3 - Journal article

VL - 5

JO - Cell Reports Medicine

JF - Cell Reports Medicine

IS - 1

M1 - 101372

ER -