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The Individual and Combined Effects of Obesity and Type 2 Diabetes on Cancer Predisposition and Survival

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Published
<mark>Journal publication date</mark>03/2015
<mark>Journal</mark>Current Nutrition Reports
Issue number1
Volume4
Number of pages11
Pages (from-to)22-32
Publication StatusPublished
<mark>Original language</mark>English

Abstract

The incidence and prevalence of obesity and type 2 diabetes mellitus continues to rise worldwide, and there is evidence which suggests that both increased body mass index (i.e., obesity) and type 2 diabetes mellitus act as independent and synergistic risk factors for the development, mortality risk, and survival of certain cancers, and thereby contribute to the increasing incidence of cancers worldwide. Numerous pathways are hypothesised to account for the independent and combined effects of obesity and diabetes on cancer predisposition and outcomes. In understanding the individual and combined effects of obesity and diabetes on cancer predisposition and survival, there are confounding factors, such as medications, biases, and weight loss, to consider.