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The mechanisms of adaptation for muscle fascicle length changes with exercise: Implications for spastic muscle

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The mechanisms of adaptation for muscle fascicle length changes with exercise: Implications for spastic muscle. / Davis, J.F.; Khir, A.W.; Barber, L. et al.
In: Medical Hypotheses, Vol. 144, 110199, 30.11.2020.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Davis, JF, Khir, AW, Barber, L, Reeves, ND, Khan, T, DeLuca, M & Mohagheghi, AA 2020, 'The mechanisms of adaptation for muscle fascicle length changes with exercise: Implications for spastic muscle', Medical Hypotheses, vol. 144, 110199. https://doi.org/10.1016/j.mehy.2020.110199

APA

Davis, J. F., Khir, A. W., Barber, L., Reeves, N. D., Khan, T., DeLuca, M., & Mohagheghi, A. A. (2020). The mechanisms of adaptation for muscle fascicle length changes with exercise: Implications for spastic muscle. Medical Hypotheses, 144, Article 110199. https://doi.org/10.1016/j.mehy.2020.110199

Vancouver

Davis JF, Khir AW, Barber L, Reeves ND, Khan T, DeLuca M et al. The mechanisms of adaptation for muscle fascicle length changes with exercise: Implications for spastic muscle. Medical Hypotheses. 2020 Nov 30;144:110199. Epub 2020 Aug 28. doi: 10.1016/j.mehy.2020.110199

Author

Davis, J.F. ; Khir, A.W. ; Barber, L. et al. / The mechanisms of adaptation for muscle fascicle length changes with exercise : Implications for spastic muscle. In: Medical Hypotheses. 2020 ; Vol. 144.

Bibtex

@article{120baeb324274af781a422f027ffdf2b,
title = "The mechanisms of adaptation for muscle fascicle length changes with exercise: Implications for spastic muscle",
abstract = "We are proposing optimal training conditions that can lead to an increase in the number of serial sarcomeres (SSN) and muscle fascicle length (FL) in spastic muscles. Therapeutic interventions for increasing FL in clinical populations with neurological origin, in whom relative shortness of muscle fascicles contributed to the presentation of symptoms such as spasticity, contracture, and limited functional abilities, do not generally meet these conditions, and therefore, result in less than satisfactory outcomes. Based on a review of literature, we argue that protocols of exercise interventions that led to sarcomerogenesis, and increases in SSN and FL in healthy animal and human models satisfied three criteria: 1) all involved eccentric exercise at appropriately high velocity; 2) resulted in positive strain of muscle fascicles; and 3) momentary deactivation in the stretched muscle. Accordingly, to increase FL in spastic muscles, new exercise protocols in which the three presumed criteria are satisfied, must be developed, and long-term muscle architectural and functional adaptations to such trainings must be examined.",
author = "J.F. Davis and A.W. Khir and L. Barber and N.D. Reeves and T. Khan and M. DeLuca and A.A. Mohagheghi",
year = "2020",
month = nov,
day = "30",
doi = "10.1016/j.mehy.2020.110199",
language = "English",
volume = "144",
journal = "Medical Hypotheses",
issn = "0306-9877",
publisher = "Churchill Livingstone",

}

RIS

TY - JOUR

T1 - The mechanisms of adaptation for muscle fascicle length changes with exercise

T2 - Implications for spastic muscle

AU - Davis, J.F.

AU - Khir, A.W.

AU - Barber, L.

AU - Reeves, N.D.

AU - Khan, T.

AU - DeLuca, M.

AU - Mohagheghi, A.A.

PY - 2020/11/30

Y1 - 2020/11/30

N2 - We are proposing optimal training conditions that can lead to an increase in the number of serial sarcomeres (SSN) and muscle fascicle length (FL) in spastic muscles. Therapeutic interventions for increasing FL in clinical populations with neurological origin, in whom relative shortness of muscle fascicles contributed to the presentation of symptoms such as spasticity, contracture, and limited functional abilities, do not generally meet these conditions, and therefore, result in less than satisfactory outcomes. Based on a review of literature, we argue that protocols of exercise interventions that led to sarcomerogenesis, and increases in SSN and FL in healthy animal and human models satisfied three criteria: 1) all involved eccentric exercise at appropriately high velocity; 2) resulted in positive strain of muscle fascicles; and 3) momentary deactivation in the stretched muscle. Accordingly, to increase FL in spastic muscles, new exercise protocols in which the three presumed criteria are satisfied, must be developed, and long-term muscle architectural and functional adaptations to such trainings must be examined.

AB - We are proposing optimal training conditions that can lead to an increase in the number of serial sarcomeres (SSN) and muscle fascicle length (FL) in spastic muscles. Therapeutic interventions for increasing FL in clinical populations with neurological origin, in whom relative shortness of muscle fascicles contributed to the presentation of symptoms such as spasticity, contracture, and limited functional abilities, do not generally meet these conditions, and therefore, result in less than satisfactory outcomes. Based on a review of literature, we argue that protocols of exercise interventions that led to sarcomerogenesis, and increases in SSN and FL in healthy animal and human models satisfied three criteria: 1) all involved eccentric exercise at appropriately high velocity; 2) resulted in positive strain of muscle fascicles; and 3) momentary deactivation in the stretched muscle. Accordingly, to increase FL in spastic muscles, new exercise protocols in which the three presumed criteria are satisfied, must be developed, and long-term muscle architectural and functional adaptations to such trainings must be examined.

U2 - 10.1016/j.mehy.2020.110199

DO - 10.1016/j.mehy.2020.110199

M3 - Journal article

VL - 144

JO - Medical Hypotheses

JF - Medical Hypotheses

SN - 0306-9877

M1 - 110199

ER -