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The pericardium promotes cardiac repair and remodelling post-myocardial infarction

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The pericardium promotes cardiac repair and remodelling post-myocardial infarction. / Mylonas, Katie; Jackson-Jones, Lucy; Andrews, Jack et al.
In: Biorxiv, 18.09.2019.

Research output: Contribution to Journal/Magazine › Journal article

Harvard

Mylonas, K, Jackson-Jones, L, Andrews, J, Magalhaes, M, Meloni, M, Joshi, N, Allen, J, Newby, D, Dweck, M, Gray, G & Benezech, C 2019, 'The pericardium promotes cardiac repair and remodelling post-myocardial infarction', Biorxiv. https://doi.org/10.1101/771154

APA

Mylonas, K., Jackson-Jones, L., Andrews, J., Magalhaes, M., Meloni, M., Joshi, N., Allen, J., Newby, D., Dweck, M., Gray, G., & Benezech, C. (2019). The pericardium promotes cardiac repair and remodelling post-myocardial infarction. Unpublished. https://doi.org/10.1101/771154

Vancouver

Mylonas K, Jackson-Jones L, Andrews J, Magalhaes M, Meloni M, Joshi N et al. The pericardium promotes cardiac repair and remodelling post-myocardial infarction. Biorxiv. 2019 Sept 18. doi: 10.1101/771154

Author

Mylonas, Katie ; Jackson-Jones, Lucy ; Andrews, Jack et al. / The pericardium promotes cardiac repair and remodelling post-myocardial infarction. In: Biorxiv. 2019.

Bibtex

@article{ba651bda86aa47f29d039a0fbed81ab6,
title = "The pericardium promotes cardiac repair and remodelling post-myocardial infarction",
abstract = "The pericardium is widely recognised for its lubricating and bio-mechanical properties. It also contains fat-associated lymphoid clusters (FALCs) and its immune functions have been widely overlooked. Here we aimed to assess the inflammatory activity of the pericardium in patients who suffered a recent myocardial infarction (MI) and to determine its importance for repair and remodelling in a murine MI model induced by coronary artery ligation (CAL). By comparing 18F-fluorodeoxyglucose (FDG) activity in the pericardium of patients with stable coronary artery disease and patients who had a recent MI, we demonstrate that MI is associated with increased pericardial inflammation. We confirm in mice, that pericardial FALCs undergo a major expansion following CAL. We show that despite similar initial injury, removal of the pericardium prior to MI disrupted subsequent repair, resulting in 50% mortality due to cardiac rupture, while all mice with intact pericardia survived. Removal of the pericardium also led to decreased staining for Ym1, a marker of reparative macrophages and adverse cardiac fibrosis within the infarct area. Together, this work indicates a crucial role for the pericardium in regulating inflammation, macrophage polarisation and tissue remodelling in the heart following MI.",
author = "Katie Mylonas and Lucy Jackson-Jones and Jack Andrews and Marlene Magalhaes and Marco Meloni and Nikhil Joshi and Judith Allen and David Newby and Marc Dweck and Gillian Gray and Cecile Benezech",
year = "2019",
month = sep,
day = "18",
doi = "10.1101/771154",
language = "English",
journal = "Biorxiv",
publisher = "Cold Spring Harbor Laboratory Press",

}

RIS

TY - JOUR

T1 - The pericardium promotes cardiac repair and remodelling post-myocardial infarction

AU - Mylonas, Katie

AU - Jackson-Jones, Lucy

AU - Andrews, Jack

AU - Magalhaes, Marlene

AU - Meloni, Marco

AU - Joshi, Nikhil

AU - Allen, Judith

AU - Newby, David

AU - Dweck, Marc

AU - Gray, Gillian

AU - Benezech, Cecile

PY - 2019/9/18

Y1 - 2019/9/18

N2 - The pericardium is widely recognised for its lubricating and bio-mechanical properties. It also contains fat-associated lymphoid clusters (FALCs) and its immune functions have been widely overlooked. Here we aimed to assess the inflammatory activity of the pericardium in patients who suffered a recent myocardial infarction (MI) and to determine its importance for repair and remodelling in a murine MI model induced by coronary artery ligation (CAL). By comparing 18F-fluorodeoxyglucose (FDG) activity in the pericardium of patients with stable coronary artery disease and patients who had a recent MI, we demonstrate that MI is associated with increased pericardial inflammation. We confirm in mice, that pericardial FALCs undergo a major expansion following CAL. We show that despite similar initial injury, removal of the pericardium prior to MI disrupted subsequent repair, resulting in 50% mortality due to cardiac rupture, while all mice with intact pericardia survived. Removal of the pericardium also led to decreased staining for Ym1, a marker of reparative macrophages and adverse cardiac fibrosis within the infarct area. Together, this work indicates a crucial role for the pericardium in regulating inflammation, macrophage polarisation and tissue remodelling in the heart following MI.

AB - The pericardium is widely recognised for its lubricating and bio-mechanical properties. It also contains fat-associated lymphoid clusters (FALCs) and its immune functions have been widely overlooked. Here we aimed to assess the inflammatory activity of the pericardium in patients who suffered a recent myocardial infarction (MI) and to determine its importance for repair and remodelling in a murine MI model induced by coronary artery ligation (CAL). By comparing 18F-fluorodeoxyglucose (FDG) activity in the pericardium of patients with stable coronary artery disease and patients who had a recent MI, we demonstrate that MI is associated with increased pericardial inflammation. We confirm in mice, that pericardial FALCs undergo a major expansion following CAL. We show that despite similar initial injury, removal of the pericardium prior to MI disrupted subsequent repair, resulting in 50% mortality due to cardiac rupture, while all mice with intact pericardia survived. Removal of the pericardium also led to decreased staining for Ym1, a marker of reparative macrophages and adverse cardiac fibrosis within the infarct area. Together, this work indicates a crucial role for the pericardium in regulating inflammation, macrophage polarisation and tissue remodelling in the heart following MI.

U2 - 10.1101/771154

DO - 10.1101/771154

M3 - Journal article

JO - Biorxiv

JF - Biorxiv

ER -