The potential of a niacinamide dominated cosmeceutical formulation on fibroblast activity and wound healing in vitro

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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The potential of a niacinamide dominated cosmeceutical formulation on fibroblast activity and wound healing in vitro. / Wessels, Quenton; Pretorius, Etheresia; Smith, Celeste M. et al.
In: International Wound Journal, Vol. 11, No. 2, 04.2014, p. 152-158.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Wessels, Q, Pretorius, E, Smith, CM & Nel, H 2014, 'The potential of a niacinamide dominated cosmeceutical formulation on fibroblast activity and wound healing in vitro', International Wound Journal, vol. 11, no. 2, pp. 152-158. https://doi.org/10.1111/j.1742-481X.2012.01052.x

APA

Wessels, Q., Pretorius, E., Smith, C. M., & Nel, H. (2014). The potential of a niacinamide dominated cosmeceutical formulation on fibroblast activity and wound healing in vitro. International Wound Journal, 11(2), 152-158. https://doi.org/10.1111/j.1742-481X.2012.01052.x

Vancouver

Wessels Q, Pretorius E, Smith CM, Nel H. The potential of a niacinamide dominated cosmeceutical formulation on fibroblast activity and wound healing in vitro. International Wound Journal. 2014 Apr;11(2):152-158. Epub 2012 Aug 14. doi: 10.1111/j.1742-481X.2012.01052.x

Author

Wessels, Quenton ; Pretorius, Etheresia ; Smith, Celeste M. et al. / The potential of a niacinamide dominated cosmeceutical formulation on fibroblast activity and wound healing in vitro. In: International Wound Journal. 2014 ; Vol. 11, No. 2. pp. 152-158.

Bibtex

@article{331a1d077cd24b5388c50c819ff3c4bb,

title = "The potential of a niacinamide dominated cosmeceutical formulation on fibroblast activity and wound healing in vitro",

abstract = "Knowledge on the intrinsic mechanisms involved in wound healing provides opportunity for various therapeutic strategies. The manipulation of dermal fibroblast proliferation and differentiation might prove to beneficially augment wound healing. This study evaluated the combined effects of niacinamide, l-carnosine, hesperidin and Biofactor HSP{\textregistered} on fibroblast activity. The effects on fibroblast collagen production, cellular proliferation, migration and terminal differentiation were assessed. In addition, the authors determined the effects on in vitro wound healing. The optimal concentrations of actives were determined in vitro. Testing parameters included microscopic morphological cell analysis, cell viability and proliferation determination, calorimetric collagen detection and in vitro wound healing dynamics. Results show that 0·31 mg/ml niacinamide, 0·10 mg/ml l-carnosine, 0·05 mg/ml hesperidin and 5·18 µg/ml Biofactor HSP{\textregistered} proved optimal in vitro. The results show that fibroblast collagen synthesis was increased alongside with cellular migration and proliferation.",

keywords = "l-Carnosine, Dermal fibroblasts , Hesperidin , HSP70 homologue , Niacinamide , Wound healing",

author = "Quenton Wessels and Etheresia Pretorius and Smith, {Celeste M.} and Hugo Nel",

year = "2014",

month = apr,

doi = "10.1111/j.1742-481X.2012.01052.x",

language = "English",

volume = "11",

pages = "152--158",

journal = "International Wound Journal",

issn = "1742-481X",

publisher = "Wiley-Blackwell",

number = "2",

}

RIS

TY - JOUR

T1 - The potential of a niacinamide dominated cosmeceutical formulation on fibroblast activity and wound healing in vitro

AU - Wessels, Quenton

AU - Pretorius, Etheresia

AU - Smith, Celeste M.

AU - Nel, Hugo

PY - 2014/4

Y1 - 2014/4

N2 - Knowledge on the intrinsic mechanisms involved in wound healing provides opportunity for various therapeutic strategies. The manipulation of dermal fibroblast proliferation and differentiation might prove to beneficially augment wound healing. This study evaluated the combined effects of niacinamide, l-carnosine, hesperidin and Biofactor HSP® on fibroblast activity. The effects on fibroblast collagen production, cellular proliferation, migration and terminal differentiation were assessed. In addition, the authors determined the effects on in vitro wound healing. The optimal concentrations of actives were determined in vitro. Testing parameters included microscopic morphological cell analysis, cell viability and proliferation determination, calorimetric collagen detection and in vitro wound healing dynamics. Results show that 0·31 mg/ml niacinamide, 0·10 mg/ml l-carnosine, 0·05 mg/ml hesperidin and 5·18 µg/ml Biofactor HSP® proved optimal in vitro. The results show that fibroblast collagen synthesis was increased alongside with cellular migration and proliferation.

AB - Knowledge on the intrinsic mechanisms involved in wound healing provides opportunity for various therapeutic strategies. The manipulation of dermal fibroblast proliferation and differentiation might prove to beneficially augment wound healing. This study evaluated the combined effects of niacinamide, l-carnosine, hesperidin and Biofactor HSP® on fibroblast activity. The effects on fibroblast collagen production, cellular proliferation, migration and terminal differentiation were assessed. In addition, the authors determined the effects on in vitro wound healing. The optimal concentrations of actives were determined in vitro. Testing parameters included microscopic morphological cell analysis, cell viability and proliferation determination, calorimetric collagen detection and in vitro wound healing dynamics. Results show that 0·31 mg/ml niacinamide, 0·10 mg/ml l-carnosine, 0·05 mg/ml hesperidin and 5·18 µg/ml Biofactor HSP® proved optimal in vitro. The results show that fibroblast collagen synthesis was increased alongside with cellular migration and proliferation.

KW - l-Carnosine

KW - Dermal fibroblasts

KW - Hesperidin

KW - HSP70 homologue

KW - Niacinamide

KW - Wound healing

U2 - 10.1111/j.1742-481X.2012.01052.x

DO - 10.1111/j.1742-481X.2012.01052.x

M3 - Journal article

VL - 11

SP - 152

EP - 158

JO - International Wound Journal

JF - International Wound Journal

SN - 1742-481X

IS - 2

ER -

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