Home > Research > Publications & Outputs > The Risk of Posttraumatic Stress Disorder After...

Research

Links

Text available via DOI:

View graph of relations

The Risk of Posttraumatic Stress Disorder After Trauma Depends on Traumatic Load and the Catechol-O-Methyltransferase Val158Met Polymorphism

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Published

Standard

The Risk of Posttraumatic Stress Disorder After Trauma Depends on Traumatic Load and the Catechol-O-Methyltransferase Val158Met Polymorphism. / Kolassa, Iris- Tatjana; Kolassa, Stephan; Ertl, Verena et al.
In: Biological Psychiatry, Vol. 67, No. 4, 2010, p. 304-308.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Kolassa, IT, Kolassa, S, Ertl, V, Papassotiropoulos, A & De Quervain, D 2010, 'The Risk of Posttraumatic Stress Disorder After Trauma Depends on Traumatic Load and the Catechol-O-Methyltransferase Val158Met Polymorphism', Biological Psychiatry, vol. 67, no. 4, pp. 304-308. https://doi.org/10.1016/j.biopsych.2009.10.009

APA

Kolassa, I. T., Kolassa, S., Ertl, V., Papassotiropoulos, A., & De Quervain, D. (2010). The Risk of Posttraumatic Stress Disorder After Trauma Depends on Traumatic Load and the Catechol-O-Methyltransferase Val158Met Polymorphism. Biological Psychiatry, 67(4), 304-308. https://doi.org/10.1016/j.biopsych.2009.10.009

Vancouver

Kolassa IT, Kolassa S, Ertl V, Papassotiropoulos A, De Quervain D. The Risk of Posttraumatic Stress Disorder After Trauma Depends on Traumatic Load and the Catechol-O-Methyltransferase Val158Met Polymorphism. Biological Psychiatry. 2010;67(4):304-308. doi: 10.1016/j.biopsych.2009.10.009

Author

Kolassa, Iris- Tatjana ; Kolassa, Stephan ; Ertl, Verena et al. / The Risk of Posttraumatic Stress Disorder After Trauma Depends on Traumatic Load and the Catechol-O-Methyltransferase Val158Met Polymorphism. In: Biological Psychiatry. 2010 ; Vol. 67, No. 4. pp. 304-308.

Bibtex

@article{8006eb08d62e44b2853ec2ed2b0b9d54,
title = "The Risk of Posttraumatic Stress Disorder After Trauma Depends on Traumatic Load and the Catechol-O-Methyltransferase Val158Met Polymorphism",
abstract = "BackgroundThe risk for posttraumatic stress disorder (PTSD) depends on the number of traumatic event types experienced in a dose–response relationship, but genetic factors are known to also influence the risk of PTSD. The catechol-O-methyltransferase (COMT) Val158Met polymorphism has been found to affect fear extinction and might play a role in the etiology of anxiety disorders.MethodsTraumatic load and lifetime and current diagnosis of PTSD and COMT genotype were assessed in a sample of 424 survivors of the Rwandan Genocide living in the Nakivale refugee camp in southwestern Uganda.ResultsHigher numbers of different lifetime traumatic event types led to a higher prevalence of lifetime PTSD in a dose–response relationship. However, this effect was modulated by the COMT genotype: whereas Val allele carriers showed the typical dose–response relationship, Met/Met homozygotes exhibited a high risk for PTSD independently of the severity of traumatic load.ConclusionsThe present findings indicate a gene–environment interaction between the human COMT Val158Met polymorphism and the number of traumatic event types experienced in the risk of developing PTSD.",
author = "Kolassa, {Iris- Tatjana} and Stephan Kolassa and Verena Ertl and A. Papassotiropoulos and {De Quervain}, D.",
year = "2010",
doi = "10.1016/j.biopsych.2009.10.009",
language = "English",
volume = "67",
pages = "304--308",
journal = "Biological Psychiatry",
issn = "0006-3223",
publisher = "Elsevier USA",
number = "4",

}

RIS

TY - JOUR

T1 - The Risk of Posttraumatic Stress Disorder After Trauma Depends on Traumatic Load and the Catechol-O-Methyltransferase Val158Met Polymorphism

AU - Kolassa, Iris- Tatjana

AU - Kolassa, Stephan

AU - Ertl, Verena

AU - Papassotiropoulos, A.

AU - De Quervain, D.

PY - 2010

Y1 - 2010

N2 - BackgroundThe risk for posttraumatic stress disorder (PTSD) depends on the number of traumatic event types experienced in a dose–response relationship, but genetic factors are known to also influence the risk of PTSD. The catechol-O-methyltransferase (COMT) Val158Met polymorphism has been found to affect fear extinction and might play a role in the etiology of anxiety disorders.MethodsTraumatic load and lifetime and current diagnosis of PTSD and COMT genotype were assessed in a sample of 424 survivors of the Rwandan Genocide living in the Nakivale refugee camp in southwestern Uganda.ResultsHigher numbers of different lifetime traumatic event types led to a higher prevalence of lifetime PTSD in a dose–response relationship. However, this effect was modulated by the COMT genotype: whereas Val allele carriers showed the typical dose–response relationship, Met/Met homozygotes exhibited a high risk for PTSD independently of the severity of traumatic load.ConclusionsThe present findings indicate a gene–environment interaction between the human COMT Val158Met polymorphism and the number of traumatic event types experienced in the risk of developing PTSD.

AB - BackgroundThe risk for posttraumatic stress disorder (PTSD) depends on the number of traumatic event types experienced in a dose–response relationship, but genetic factors are known to also influence the risk of PTSD. The catechol-O-methyltransferase (COMT) Val158Met polymorphism has been found to affect fear extinction and might play a role in the etiology of anxiety disorders.MethodsTraumatic load and lifetime and current diagnosis of PTSD and COMT genotype were assessed in a sample of 424 survivors of the Rwandan Genocide living in the Nakivale refugee camp in southwestern Uganda.ResultsHigher numbers of different lifetime traumatic event types led to a higher prevalence of lifetime PTSD in a dose–response relationship. However, this effect was modulated by the COMT genotype: whereas Val allele carriers showed the typical dose–response relationship, Met/Met homozygotes exhibited a high risk for PTSD independently of the severity of traumatic load.ConclusionsThe present findings indicate a gene–environment interaction between the human COMT Val158Met polymorphism and the number of traumatic event types experienced in the risk of developing PTSD.

U2 - 10.1016/j.biopsych.2009.10.009

DO - 10.1016/j.biopsych.2009.10.009

M3 - Journal article

VL - 67

SP - 304

EP - 308

JO - Biological Psychiatry

JF - Biological Psychiatry

SN - 0006-3223

IS - 4

ER -