TY - JOUR

T1 - There is no dose–response relationship between the amount of exercise and improvement in HbA1c in interventions over 12 weeks in patients with type 2 diabetes

T2 - a meta-analysis and meta-regression

AU - Wrench, E.

AU - Rattley, K.

AU - Lambert, J.E.

AU - Killick, R.

AU - Hayes, L.D.

AU - Lauder, R.M.

AU - Gaffney, C.J.

PY - 2022/11/30

Y1 - 2022/11/30

N2 - Abstract: Aims: Aerobic exercise is well recognised as an effective treatment for people with type 2 diabetes but the optimal amount of aerobic exercise to improve glycaemic control remains to be determined. Thus, the aim of this meta-analysis and meta-regression was to assess the impact of volume and intensity of aerobic exercise on glycaemic control. Methods: Medline, Cochrane, Embase, and Web of Science databases were searched up until 15 December 2020 for the terms “aerobic exercise AND glycaemic control”, “type 2 diabetes AND exercise”, and “exercise AND glycaemic control AND Type 2 diabetes AND randomised control trial”. We included (i) randomised control trials of ≥ 12 weeks, (ii) trials where participants had type 2 diabetes and were aged 18 or over, and (iii) the trial reported HbA1c concentrations pre- and post-intervention. Two reviewers selected studies and extracted data. Data are reported as standardised mean difference (SMD) and publication bias was assessed using funnel plots. Results: A total of 5364 original titles were identified. Sixteen studies were included in the meta-analysis. Aerobic exercise reduced HbA1c versus control (SMD = 0.56 (95% CI 0.3–0.82), p < 0.001). There were also significant reductions in BMI (SMD = 0.76 (95% CI 0.25–1.27), p < 0.05). There was no dose–response relationship between improvement in HbA1c and the intensity and volume of the intervention (p > 0.05). Conclusions: Twelve-week or longer aerobic exercise programmes improve glycaemic control and BMI in adults with type 2 diabetes. Longer or more intense interventions appear to confer no additional benefit on HbA1c.

AB - Abstract: Aims: Aerobic exercise is well recognised as an effective treatment for people with type 2 diabetes but the optimal amount of aerobic exercise to improve glycaemic control remains to be determined. Thus, the aim of this meta-analysis and meta-regression was to assess the impact of volume and intensity of aerobic exercise on glycaemic control. Methods: Medline, Cochrane, Embase, and Web of Science databases were searched up until 15 December 2020 for the terms “aerobic exercise AND glycaemic control”, “type 2 diabetes AND exercise”, and “exercise AND glycaemic control AND Type 2 diabetes AND randomised control trial”. We included (i) randomised control trials of ≥ 12 weeks, (ii) trials where participants had type 2 diabetes and were aged 18 or over, and (iii) the trial reported HbA1c concentrations pre- and post-intervention. Two reviewers selected studies and extracted data. Data are reported as standardised mean difference (SMD) and publication bias was assessed using funnel plots. Results: A total of 5364 original titles were identified. Sixteen studies were included in the meta-analysis. Aerobic exercise reduced HbA1c versus control (SMD = 0.56 (95% CI 0.3–0.82), p < 0.001). There were also significant reductions in BMI (SMD = 0.76 (95% CI 0.25–1.27), p < 0.05). There was no dose–response relationship between improvement in HbA1c and the intensity and volume of the intervention (p > 0.05). Conclusions: Twelve-week or longer aerobic exercise programmes improve glycaemic control and BMI in adults with type 2 diabetes. Longer or more intense interventions appear to confer no additional benefit on HbA1c.

KW - Aerobic exercise

KW - Glycaemic control

KW - HbA1c

KW - Type 2 diabetes

U2 - 10.1007/s00592-022-01918-8

DO - 10.1007/s00592-022-01918-8

M3 - Review article

C2 - 35930075

VL - 59

SP - 1399

EP - 1415

JO - Acta Diabetologica

JF - Acta Diabetologica

SN - 1432-5233

IS - 11

ER -