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Time for CHANGE: System-level interventions for bringing forward the date of effective use of NAMs in regulatory toxicology

Research output: Contribution to Journal/Magazine › Editorial

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Time for CHANGE: System-level interventions for bringing forward the date of effective use of NAMs in regulatory toxicology. / Mathisen, Gro H; Bearth, Angela; Jones, Lowenna B et al.
In: Archives of Toxicology, Vol. 98, No. 8, 01.08.2024, p. 2299-2308.

Research output: Contribution to Journal/Magazine › Editorial

Harvard

Mathisen, GH, Bearth, A, Jones, LB, Hoffmann, S, Vist, GE, Ames, HM, Husøy, T, Svendsen, C, Tsaioun, K, Ashikaga, T, Bloch, D, Cavoski, A, Chiu, WA, Davies, HG, Giusti, A, Hartung, T, Hirabayashi, Y, Hogberg, HT, Joglekar, R, Kojima, H, Krishnan, K, Kwon, S, Osborne, OJ, Roggen, E, Rooney, AA, Rousselle, C, Sass, JB, Sepai, O, Simanainen, U, Thayer, KA, Tong, W, Wikoff, D, Wright, F & Whaley, P 2024, 'Time for CHANGE: System-level interventions for bringing forward the date of effective use of NAMs in regulatory toxicology', Archives of Toxicology, vol. 98, no. 8, pp. 2299-2308. https://doi.org/10.1007/s00204-024-03802-6

APA

Mathisen, G. H., Bearth, A., Jones, L. B., Hoffmann, S., Vist, G. E., Ames, H. M., Husøy, T., Svendsen, C., Tsaioun, K., Ashikaga, T., Bloch, D., Cavoski, A., Chiu, W. A., Davies, H. G., Giusti, A., Hartung, T., Hirabayashi, Y., Hogberg, H. T., Joglekar, R., ... Whaley, P. (2024). Time for CHANGE: System-level interventions for bringing forward the date of effective use of NAMs in regulatory toxicology. Archives of Toxicology, 98(8), 2299-2308. https://doi.org/10.1007/s00204-024-03802-6

Vancouver

Mathisen GH, Bearth A, Jones LB, Hoffmann S, Vist GE, Ames HM et al. Time for CHANGE: System-level interventions for bringing forward the date of effective use of NAMs in regulatory toxicology. Archives of Toxicology. 2024 Aug 1;98(8):2299-2308. Epub 2024 Jun 14. doi: 10.1007/s00204-024-03802-6

Author

Mathisen, Gro H ; Bearth, Angela ; Jones, Lowenna B et al. / Time for CHANGE : System-level interventions for bringing forward the date of effective use of NAMs in regulatory toxicology. In: Archives of Toxicology. 2024 ; Vol. 98, No. 8. pp. 2299-2308.

Bibtex

@article{6193cb27465c454faa83798215fd9609,
title = "Time for CHANGE: System-level interventions for bringing forward the date of effective use of NAMs in regulatory toxicology",
abstract = "There has been considerable work over the past 20 years designed to bring about a paradigm shift in regulatory toxicology from chemical risk management decisions based on data from animal studies to a “Next Generation Risk Assessments” (NGRAs) system founded on New Approach Methods (NAMs). The perceived potential benefits of NAMs that are driving the paradigm shift include better protection of humans and the environment, the reduction of animal testing, and ultimately, a faster and more cost-effective test systems for evaluating chemical safety. In this article, we introduce the “Collaboration to Harmonise the Assessment of Next Generation Evidence” (CHANGE) project, a new initiative that seeks to design system-level interventions for bringing forward the date of effective use of NAMs, explaining its goals, approach, project management, governance, and funding.",
keywords = "Animals, Humans, Toxicology",
author = "Mathisen, {Gro H} and Angela Bearth and Jones, {Lowenna B} and Sebastian Hoffmann and Vist, {Gunn E} and Ames, {Heather M} and Trine Hus{\o}y and Camilla Svendsen and Katya Tsaioun and Takao Ashikaga and Denise Bloch and Aleksandra Cavoski and Chiu, {Weihsueh A} and Davies, {Holly G} and Arianna Giusti and Thomas Hartung and Yoko Hirabayashi and Hogberg, {Helena T} and Rashmi Joglekar and Hajime Kojima and Kannan Krishnan and Seok Kwon and Osborne, {Olivia J} and Erwin Roggen and Rooney, {Andrew A} and Christophe Rousselle and Sass, {Jennifer B} and Ovnair Sepai and Ulla Simanainen and Thayer, {Kristina A} and Weida Tong and Daniele Wikoff and Fred Wright and Paul Whaley",
year = "2024",
month = aug,
day = "1",
doi = "10.1007/s00204-024-03802-6",
language = "English",
volume = "98",
pages = "2299--2308",
journal = "Archives of Toxicology",
issn = "0340-5761",
publisher = "Springer Verlag",
number = "8",

}

RIS

TY - JOUR

T1 - Time for CHANGE

T2 - System-level interventions for bringing forward the date of effective use of NAMs in regulatory toxicology

AU - Mathisen, Gro H

AU - Bearth, Angela

AU - Jones, Lowenna B

AU - Hoffmann, Sebastian

AU - Vist, Gunn E

AU - Ames, Heather M

AU - Husøy, Trine

AU - Svendsen, Camilla

AU - Tsaioun, Katya

AU - Ashikaga, Takao

AU - Bloch, Denise

AU - Cavoski, Aleksandra

AU - Chiu, Weihsueh A

AU - Davies, Holly G

AU - Giusti, Arianna

AU - Hartung, Thomas

AU - Hirabayashi, Yoko

AU - Hogberg, Helena T

AU - Joglekar, Rashmi

AU - Kojima, Hajime

AU - Krishnan, Kannan

AU - Kwon, Seok

AU - Osborne, Olivia J

AU - Roggen, Erwin

AU - Rooney, Andrew A

AU - Rousselle, Christophe

AU - Sass, Jennifer B

AU - Sepai, Ovnair

AU - Simanainen, Ulla

AU - Thayer, Kristina A

AU - Tong, Weida

AU - Wikoff, Daniele

AU - Wright, Fred

AU - Whaley, Paul

PY - 2024/8/1

Y1 - 2024/8/1

N2 - There has been considerable work over the past 20 years designed to bring about a paradigm shift in regulatory toxicology from chemical risk management decisions based on data from animal studies to a “Next Generation Risk Assessments” (NGRAs) system founded on New Approach Methods (NAMs). The perceived potential benefits of NAMs that are driving the paradigm shift include better protection of humans and the environment, the reduction of animal testing, and ultimately, a faster and more cost-effective test systems for evaluating chemical safety. In this article, we introduce the “Collaboration to Harmonise the Assessment of Next Generation Evidence” (CHANGE) project, a new initiative that seeks to design system-level interventions for bringing forward the date of effective use of NAMs, explaining its goals, approach, project management, governance, and funding.

AB - There has been considerable work over the past 20 years designed to bring about a paradigm shift in regulatory toxicology from chemical risk management decisions based on data from animal studies to a “Next Generation Risk Assessments” (NGRAs) system founded on New Approach Methods (NAMs). The perceived potential benefits of NAMs that are driving the paradigm shift include better protection of humans and the environment, the reduction of animal testing, and ultimately, a faster and more cost-effective test systems for evaluating chemical safety. In this article, we introduce the “Collaboration to Harmonise the Assessment of Next Generation Evidence” (CHANGE) project, a new initiative that seeks to design system-level interventions for bringing forward the date of effective use of NAMs, explaining its goals, approach, project management, governance, and funding.

KW - Animals

KW - Humans

KW - Toxicology

U2 - 10.1007/s00204-024-03802-6

DO - 10.1007/s00204-024-03802-6

M3 - Editorial

C2 - 38877155

VL - 98

SP - 2299

EP - 2308

JO - Archives of Toxicology

JF - Archives of Toxicology

SN - 0340-5761

IS - 8

ER -