Final published version
Research output: Contribution to Journal/Magazine › Review article › peer-review
Research output: Contribution to Journal/Magazine › Review article › peer-review
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TY - JOUR
T1 - Trabecular Bone Score to Enhance Fracture Risk Prediction and Treatment Strategies in Osteoporosis
AU - Gatineau, Guillaume
AU - Hans, Didier
AU - Hind, Karen
PY - 2024/10/15
Y1 - 2024/10/15
N2 - The Trabecular Bone Score (TBS), a gray-level textural assessment derived from dual-energy X-ray absorptiometry images, serves as a validated index of trabecular bone microarchitecture. Over the past decade, significant evidence has highlighted the usefulness of TBS in primary and secondary osteoporosis, leading to its integration with the Fracture Risk Assessment Tool (FRAX) and bone mineral density (BMD) T-score adjustments. This review explores the role of TBS in fracture prediction, treatment initiation, and monitoring. Studies confirm that TBS enhances fracture risk prediction in both primary and secondary osteoporosis when combined with BMD and clinical risk factors. Evidence also suggests that including TBS alongside BMD and FRAX offers significant potential for treatment stratification, considering the overall skeletal profile, such as bone mass, bone quality, and clinical risk factors. Consequently, TBS has become a standard part of clinical care worldwide. Future enhancements hope to adjust for soft tissue thickness, broadening the applicability of TBS across diverse body types and pediatric populations. [Abstract copyright: Thieme. All rights reserved.]
AB - The Trabecular Bone Score (TBS), a gray-level textural assessment derived from dual-energy X-ray absorptiometry images, serves as a validated index of trabecular bone microarchitecture. Over the past decade, significant evidence has highlighted the usefulness of TBS in primary and secondary osteoporosis, leading to its integration with the Fracture Risk Assessment Tool (FRAX) and bone mineral density (BMD) T-score adjustments. This review explores the role of TBS in fracture prediction, treatment initiation, and monitoring. Studies confirm that TBS enhances fracture risk prediction in both primary and secondary osteoporosis when combined with BMD and clinical risk factors. Evidence also suggests that including TBS alongside BMD and FRAX offers significant potential for treatment stratification, considering the overall skeletal profile, such as bone mass, bone quality, and clinical risk factors. Consequently, TBS has become a standard part of clinical care worldwide. Future enhancements hope to adjust for soft tissue thickness, broadening the applicability of TBS across diverse body types and pediatric populations. [Abstract copyright: Thieme. All rights reserved.]
KW - Bone Density
KW - Osteoporosis - diagnostic imaging
KW - Risk Assessment - methods
KW - Humans
KW - Absorptiometry, Photon - methods
KW - Risk Factors
KW - Osteoporotic Fractures - diagnostic imaging
KW - Cancellous Bone - diagnostic imaging
U2 - 10.1055/s-0044-1788886
DO - 10.1055/s-0044-1788886
M3 - Review article
C2 - 39406217
VL - 28
SP - 539
EP - 546
JO - Seminars in musculoskeletal radiology
JF - Seminars in musculoskeletal radiology
SN - 1098-898X
IS - 5
ER -