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Transforming growth factor beta gene signatures are spatially enriched in keloid tissue biopsies and ex vivo-cultured keloid fibroblasts

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  • A. Taylor
  • D.C. Budd
  • B. Shih
  • O. Seifert
  • A. Beaton
  • T. Wright
  • M. Dempsey
  • F. Kelly
  • J. Egerton
  • R.P. Marshall
  • N. Aston
  • A. Bayat
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<mark>Journal publication date</mark>4/01/2017
<mark>Journal</mark>Acta dermato-venereologica
Issue number1
Volume97
Number of pages7
Pages (from-to)10-16
Publication StatusPublished
Early online date29/06/16
<mark>Original language</mark>English

Abstract

The keloid lesion is recognised as a spatially heterogeneous mass both in cellular and acellular composition and biological activity. Here, we have utilised a bioinformatic approach to determine whether this spatial heterogeneity is also evident at the molecular level and to identify key upstream regulators of signalling pathways enriched in the lesion in a spatially-restricted manner. Differentially expressed genes (20% change, p