Final published version
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Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Transforming growth factor beta gene signatures are spatially enriched in keloid tissue biopsies and ex vivo-cultured keloid fibroblasts
AU - Taylor, A.
AU - Budd, D.C.
AU - Shih, B.
AU - Seifert, O.
AU - Beaton, A.
AU - Wright, T.
AU - Dempsey, M.
AU - Kelly, F.
AU - Egerton, J.
AU - Marshall, R.P.
AU - Aston, N.
AU - Bayat, A.
PY - 2017/1/4
Y1 - 2017/1/4
N2 - The keloid lesion is recognised as a spatially heterogeneous mass both in cellular and acellular composition and biological activity. Here, we have utilised a bioinformatic approach to determine whether this spatial heterogeneity is also evident at the molecular level and to identify key upstream regulators of signalling pathways enriched in the lesion in a spatially-restricted manner. Differentially expressed genes (20% change, p
AB - The keloid lesion is recognised as a spatially heterogeneous mass both in cellular and acellular composition and biological activity. Here, we have utilised a bioinformatic approach to determine whether this spatial heterogeneity is also evident at the molecular level and to identify key upstream regulators of signalling pathways enriched in the lesion in a spatially-restricted manner. Differentially expressed genes (20% change, p
U2 - 10.2340/00015555-2462
DO - 10.2340/00015555-2462
M3 - Journal article
VL - 97
SP - 10
EP - 16
JO - Acta dermato-venereologica
JF - Acta dermato-venereologica
SN - 1651-2057
IS - 1
ER -