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Trauma-focused therapy in early psychosis: Results of a feasibility randomized controlled trial of EMDR for psychosis (EMDRp) in early intervention settings

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Trauma-focused therapy in early psychosis: Results of a feasibility randomized controlled trial of EMDR for psychosis (EMDRp) in early intervention settings. / Varese, Filippo; Sellwood, Bill; Pulford, Daniel et al.
In: Psychological Medicine, Vol. 54, No. 5, 01.04.2024, p. 874 - 885.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Varese, F, Sellwood, B, Pulford, D, Awanat, Y, Bird, L, Bhutani, G, Carter, L-A, Davies, L, Aseem, S, Davis, C, Hefferman-Clarke, R, Hilton, C, Horne, G, Keane, D, Logie, R, Malkin, D, Potter, F, van den Berg , D, Zia, S & Bentall, R 2024, 'Trauma-focused therapy in early psychosis: Results of a feasibility randomized controlled trial of EMDR for psychosis (EMDRp) in early intervention settings', Psychological Medicine, vol. 54, no. 5, pp. 874 - 885. https://doi.org/10.1017/S0033291723002532

APA

Varese, F., Sellwood, B., Pulford, D., Awanat, Y., Bird, L., Bhutani, G., Carter, L-A., Davies, L., Aseem, S., Davis, C., Hefferman-Clarke, R., Hilton, C., Horne, G., Keane, D., Logie, R., Malkin, D., Potter, F., van den Berg , D., Zia, S., & Bentall, R. (2024). Trauma-focused therapy in early psychosis: Results of a feasibility randomized controlled trial of EMDR for psychosis (EMDRp) in early intervention settings. Psychological Medicine, 54(5), 874 - 885. https://doi.org/10.1017/S0033291723002532

Vancouver

Varese F, Sellwood B, Pulford D, Awanat Y, Bird L, Bhutani G et al. Trauma-focused therapy in early psychosis: Results of a feasibility randomized controlled trial of EMDR for psychosis (EMDRp) in early intervention settings. Psychological Medicine. 2024 Apr 1;54(5):874 - 885. Epub 2023 Oct 26. doi: 10.1017/S0033291723002532

Author

Varese, Filippo ; Sellwood, Bill ; Pulford, Daniel et al. / Trauma-focused therapy in early psychosis : Results of a feasibility randomized controlled trial of EMDR for psychosis (EMDRp) in early intervention settings. In: Psychological Medicine. 2024 ; Vol. 54, No. 5. pp. 874 - 885.

Bibtex

@article{9c55ccbf20764033900eef56cd99cf41,
title = "Trauma-focused therapy in early psychosis: Results of a feasibility randomized controlled trial of EMDR for psychosis (EMDRp) in early intervention settings",
abstract = "Background Trauma is prevalent amongst early psychosis patients and associated with adverse outcomes. Past trials of trauma-focused therapy have focused on chronic patients with psychosis/schizophrenia and comorbid Post-Traumatic Stress Disorder (PTSD). We aimed to determine the feasibility of a large-scale randomized controlled trial (RCT) of an Eye Movement Desensitization and Reprocessing for psychosis (EMDRp) intervention for early psychosis service users. Methods A single-blind RCT comparing 16 sessions of EMDRp + TAU v. TAU only was conducted. Participants completed baseline, 6-month and 12-month post-randomization assessments. EMDRp and trial assessments were delivered both in-person and remotely due to COVID-19 restrictions. Feasibility outcomes were recruitment and retention, therapy attendance/engagement, adherence to EMDRp treatment protocol, and the 'promise of efficacy' of EMDRp on relevant clinical outcomes. Results Sixty participants (100% of the recruitment target) received TAU or EMDR + TAU. 83% completed at least one follow-up assessment, with 74% at 6-month and 70% at 12-month. 74% of EMDRp + TAU participants received at least eight therapy sessions and 97% rated therapy sessions demonstrated good treatment fidelity. At 6-month, there were signals of promise of efficacy of EMDRp + TAU v. TAU for total psychotic symptoms (PANSS), subjective recovery from psychosis, PTSD symptoms, depression, anxiety, and general health status. Signals of efficacy at 12-month were less pronounced but remained robust for PTSD symptoms and general health status. Conclusions The trial feasibility criteria were fully met, and EMDRp was associated with promising signals of efficacy on a range of valuable clinical outcomes. A larger-scale, multi-center trial of EMDRp is feasible and warranted.",
keywords = "Trauma, eye movement desensitization and reprocessing, psychological therapies, psychosis, randomized controlled trial",
author = "Filippo Varese and Bill Sellwood and Daniel Pulford and Yvonne Awanat and Leanne Bird and Gita Bhutani and Lesley-Anne Carter and Linda Davies and Saadia Aseem and Claire Davis and Rebecca Hefferman-Clarke and Claire Hilton and Georgia Horne and David Keane and Robin Logie and Debra Malkin and Fiona Potter and {van den Berg}, David and Shameem Zia and Richard Bentall",
year = "2024",
month = apr,
day = "1",
doi = "10.1017/S0033291723002532",
language = "English",
volume = "54",
pages = "874 -- 885",
journal = "Psychological Medicine",
issn = "0033-2917",
publisher = "Cambridge University Press",
number = "5",

}

RIS

TY - JOUR

T1 - Trauma-focused therapy in early psychosis

T2 - Results of a feasibility randomized controlled trial of EMDR for psychosis (EMDRp) in early intervention settings

AU - Varese, Filippo

AU - Sellwood, Bill

AU - Pulford, Daniel

AU - Awanat, Yvonne

AU - Bird, Leanne

AU - Bhutani, Gita

AU - Carter, Lesley-Anne

AU - Davies, Linda

AU - Aseem, Saadia

AU - Davis, Claire

AU - Hefferman-Clarke, Rebecca

AU - Hilton, Claire

AU - Horne, Georgia

AU - Keane, David

AU - Logie, Robin

AU - Malkin, Debra

AU - Potter, Fiona

AU - van den Berg , David

AU - Zia, Shameem

AU - Bentall, Richard

PY - 2024/4/1

Y1 - 2024/4/1

N2 - Background Trauma is prevalent amongst early psychosis patients and associated with adverse outcomes. Past trials of trauma-focused therapy have focused on chronic patients with psychosis/schizophrenia and comorbid Post-Traumatic Stress Disorder (PTSD). We aimed to determine the feasibility of a large-scale randomized controlled trial (RCT) of an Eye Movement Desensitization and Reprocessing for psychosis (EMDRp) intervention for early psychosis service users. Methods A single-blind RCT comparing 16 sessions of EMDRp + TAU v. TAU only was conducted. Participants completed baseline, 6-month and 12-month post-randomization assessments. EMDRp and trial assessments were delivered both in-person and remotely due to COVID-19 restrictions. Feasibility outcomes were recruitment and retention, therapy attendance/engagement, adherence to EMDRp treatment protocol, and the 'promise of efficacy' of EMDRp on relevant clinical outcomes. Results Sixty participants (100% of the recruitment target) received TAU or EMDR + TAU. 83% completed at least one follow-up assessment, with 74% at 6-month and 70% at 12-month. 74% of EMDRp + TAU participants received at least eight therapy sessions and 97% rated therapy sessions demonstrated good treatment fidelity. At 6-month, there were signals of promise of efficacy of EMDRp + TAU v. TAU for total psychotic symptoms (PANSS), subjective recovery from psychosis, PTSD symptoms, depression, anxiety, and general health status. Signals of efficacy at 12-month were less pronounced but remained robust for PTSD symptoms and general health status. Conclusions The trial feasibility criteria were fully met, and EMDRp was associated with promising signals of efficacy on a range of valuable clinical outcomes. A larger-scale, multi-center trial of EMDRp is feasible and warranted.

AB - Background Trauma is prevalent amongst early psychosis patients and associated with adverse outcomes. Past trials of trauma-focused therapy have focused on chronic patients with psychosis/schizophrenia and comorbid Post-Traumatic Stress Disorder (PTSD). We aimed to determine the feasibility of a large-scale randomized controlled trial (RCT) of an Eye Movement Desensitization and Reprocessing for psychosis (EMDRp) intervention for early psychosis service users. Methods A single-blind RCT comparing 16 sessions of EMDRp + TAU v. TAU only was conducted. Participants completed baseline, 6-month and 12-month post-randomization assessments. EMDRp and trial assessments were delivered both in-person and remotely due to COVID-19 restrictions. Feasibility outcomes were recruitment and retention, therapy attendance/engagement, adherence to EMDRp treatment protocol, and the 'promise of efficacy' of EMDRp on relevant clinical outcomes. Results Sixty participants (100% of the recruitment target) received TAU or EMDR + TAU. 83% completed at least one follow-up assessment, with 74% at 6-month and 70% at 12-month. 74% of EMDRp + TAU participants received at least eight therapy sessions and 97% rated therapy sessions demonstrated good treatment fidelity. At 6-month, there were signals of promise of efficacy of EMDRp + TAU v. TAU for total psychotic symptoms (PANSS), subjective recovery from psychosis, PTSD symptoms, depression, anxiety, and general health status. Signals of efficacy at 12-month were less pronounced but remained robust for PTSD symptoms and general health status. Conclusions The trial feasibility criteria were fully met, and EMDRp was associated with promising signals of efficacy on a range of valuable clinical outcomes. A larger-scale, multi-center trial of EMDRp is feasible and warranted.

KW - Trauma

KW - eye movement desensitization and reprocessing

KW - psychological therapies

KW - psychosis

KW - randomized controlled trial

U2 - 10.1017/S0033291723002532

DO - 10.1017/S0033291723002532

M3 - Journal article

VL - 54

SP - 874

EP - 885

JO - Psychological Medicine

JF - Psychological Medicine

SN - 0033-2917

IS - 5

ER -