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Trial design for evaluating novel treatments during an outbreak of an infectious disease

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Trial design for evaluating novel treatments during an outbreak of an infectious disease. / Whitehead, John Raymond; Olliaro, Piero; Lang, Trudie et al.
In: Clinical Trials, Vol. 13, No. 1, 02.2016, p. 31-38.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Whitehead, JR, Olliaro, P, Lang, T & Horby, PW 2016, 'Trial design for evaluating novel treatments during an outbreak of an infectious disease', Clinical Trials, vol. 13, no. 1, pp. 31-38. https://doi.org/10.1177/1740774515617740

APA

Whitehead, J. R., Olliaro, P., Lang, T., & Horby, P. W. (2016). Trial design for evaluating novel treatments during an outbreak of an infectious disease. Clinical Trials, 13(1), 31-38. https://doi.org/10.1177/1740774515617740

Vancouver

Whitehead JR, Olliaro P, Lang T, Horby PW. Trial design for evaluating novel treatments during an outbreak of an infectious disease. Clinical Trials. 2016 Feb;13(1):31-38. Epub 2016 Jan 14. doi: 10.1177/1740774515617740

Author

Whitehead, John Raymond ; Olliaro, Piero ; Lang, Trudie et al. / Trial design for evaluating novel treatments during an outbreak of an infectious disease. In: Clinical Trials. 2016 ; Vol. 13, No. 1. pp. 31-38.

Bibtex

@article{d1bf2bf374c34f858f62a44a11a2a04a,
title = "Trial design for evaluating novel treatments during an outbreak of an infectious disease",
abstract = "Tragically, the outbreak of Ebola that started in West Africa in 2014 has been far more extensive and damaging than any previous outbreaks. The duration of the outbreak has, for the first time, allowed the clinical evaluation of Ebola treatments. This article discusses the designs used for two such clinical trials which have recruited patients in Liberia and Sierra Leone. General principles are outlined for trial designs intended to be deployed quickly, adapt flexibly and provide results soon enough to influence the course of the current epidemic rather than just providing evidence for use should Ebola break out again. Lessons are drawn for the conduct of clinical research in future outbreaks of infectious diseases, where the sequence of events may or may not be similar to the West African Ebola epidemic.",
author = "Whitehead, {John Raymond} and Piero Olliaro and Trudie Lang and Horby, {Peter W.}",
year = "2016",
month = feb,
doi = "10.1177/1740774515617740",
language = "English",
volume = "13",
pages = "31--38",
journal = "Clinical Trials",
issn = "1740-7745",
publisher = "SAGE Publications Ltd",
number = "1",

}

RIS

TY - JOUR

T1 - Trial design for evaluating novel treatments during an outbreak of an infectious disease

AU - Whitehead, John Raymond

AU - Olliaro, Piero

AU - Lang, Trudie

AU - Horby, Peter W.

PY - 2016/2

Y1 - 2016/2

N2 - Tragically, the outbreak of Ebola that started in West Africa in 2014 has been far more extensive and damaging than any previous outbreaks. The duration of the outbreak has, for the first time, allowed the clinical evaluation of Ebola treatments. This article discusses the designs used for two such clinical trials which have recruited patients in Liberia and Sierra Leone. General principles are outlined for trial designs intended to be deployed quickly, adapt flexibly and provide results soon enough to influence the course of the current epidemic rather than just providing evidence for use should Ebola break out again. Lessons are drawn for the conduct of clinical research in future outbreaks of infectious diseases, where the sequence of events may or may not be similar to the West African Ebola epidemic.

AB - Tragically, the outbreak of Ebola that started in West Africa in 2014 has been far more extensive and damaging than any previous outbreaks. The duration of the outbreak has, for the first time, allowed the clinical evaluation of Ebola treatments. This article discusses the designs used for two such clinical trials which have recruited patients in Liberia and Sierra Leone. General principles are outlined for trial designs intended to be deployed quickly, adapt flexibly and provide results soon enough to influence the course of the current epidemic rather than just providing evidence for use should Ebola break out again. Lessons are drawn for the conduct of clinical research in future outbreaks of infectious diseases, where the sequence of events may or may not be similar to the West African Ebola epidemic.

U2 - 10.1177/1740774515617740

DO - 10.1177/1740774515617740

M3 - Journal article

VL - 13

SP - 31

EP - 38

JO - Clinical Trials

JF - Clinical Trials

SN - 1740-7745

IS - 1

ER -