ULTRASTRUCTURAL DISTRIBUTION OF ENDOGENOUS IMMUNOGLOBULIN-G IN HUMAN TERM AMNIOCHORION

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ULTRASTRUCTURAL DISTRIBUTION OF ENDOGENOUS IMMUNOGLOBULIN-G IN HUMAN TERM AMNIOCHORION. / BRIGHT, N A ; OCKLEFORD, C D .
In: Cell and Tissue Research, Vol. 281, No. 2, 08.1995, p. 367-374.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

BRIGHT, NA & OCKLEFORD, CD 1995, 'ULTRASTRUCTURAL DISTRIBUTION OF ENDOGENOUS IMMUNOGLOBULIN-G IN HUMAN TERM AMNIOCHORION', Cell and Tissue Research, vol. 281, no. 2, pp. 367-374. https://doi.org/10.1007/BF00583405

APA

BRIGHT, N. A., & OCKLEFORD, C. D. (1995). ULTRASTRUCTURAL DISTRIBUTION OF ENDOGENOUS IMMUNOGLOBULIN-G IN HUMAN TERM AMNIOCHORION. Cell and Tissue Research, 281(2), 367-374. https://doi.org/10.1007/BF00583405

Vancouver

BRIGHT NA, OCKLEFORD CD. ULTRASTRUCTURAL DISTRIBUTION OF ENDOGENOUS IMMUNOGLOBULIN-G IN HUMAN TERM AMNIOCHORION. Cell and Tissue Research. 1995 Aug;281(2):367-374. doi: 10.1007/BF00583405

Author

BRIGHT, N A ; OCKLEFORD, C D . / ULTRASTRUCTURAL DISTRIBUTION OF ENDOGENOUS IMMUNOGLOBULIN-G IN HUMAN TERM AMNIOCHORION. In: Cell and Tissue Research. 1995 ; Vol. 281, No. 2. pp. 367-374.

Bibtex

@article{4ef7ba4ad4b647029bc815b3463a08c7,

title = "ULTRASTRUCTURAL DISTRIBUTION OF ENDOGENOUS IMMUNOGLOBULIN-G IN HUMAN TERM AMNIOCHORION",

abstract = "Maternal immunoglobulin-G (IgG) is known to be transported across the placental syncytiotrophoblast during the period when the human fetus is incapable of manufacturing these defensive molecules. In this study we investigated the possible role of the amniochorion, that surrounds the amniotic cavity in which the fetus lies, in the transfer of immunoglobulin. Endogenous IgG was localised in the amniochorion by confocal immunofluorescence microscopy and by ultrastructural labelling of ultrathin frozen tissue sections using the protein A-gold technique. Immunoreactivity was identified in the extracellular matrix tissues and necrotic amniotic epithelial cells. Healthy amniotic epithelial cells and cytotrophoblast cells of the chorion laeve were devoid of endogenous IgG. These results suggest a possible nonspecific paracellular transport pathway between cytotrophoblast cells, which may conceivably contribute to the acquisition of passive immunity by the fetus, and offer a rational explanation for the presence of small quantities of maternal IgG in the amniotic fluid.",

keywords = "PLACENTA, AMNIOCHORION, CYTOTROPHOBLAST CELLS, IMMUNOGLOBULIN-G, IMMUNOCYTOCHEMISTRY, HUMAN, ULTRATHIN FROZEN-SECTIONS, PLACENTAL-TRANSFER, IGG SUBCLASSES",

author = "BRIGHT, {N A} and OCKLEFORD, {C D}",

year = "1995",

month = aug,

doi = "10.1007/BF00583405",

language = "English",

volume = "281",

pages = "367--374",

journal = "Cell and Tissue Research",

issn = "0302-766X",

publisher = "Springer Verlag",

number = "2",

}

RIS

TY - JOUR

T1 - ULTRASTRUCTURAL DISTRIBUTION OF ENDOGENOUS IMMUNOGLOBULIN-G IN HUMAN TERM AMNIOCHORION

AU - BRIGHT, N A

AU - OCKLEFORD, C D

PY - 1995/8

Y1 - 1995/8

N2 - Maternal immunoglobulin-G (IgG) is known to be transported across the placental syncytiotrophoblast during the period when the human fetus is incapable of manufacturing these defensive molecules. In this study we investigated the possible role of the amniochorion, that surrounds the amniotic cavity in which the fetus lies, in the transfer of immunoglobulin. Endogenous IgG was localised in the amniochorion by confocal immunofluorescence microscopy and by ultrastructural labelling of ultrathin frozen tissue sections using the protein A-gold technique. Immunoreactivity was identified in the extracellular matrix tissues and necrotic amniotic epithelial cells. Healthy amniotic epithelial cells and cytotrophoblast cells of the chorion laeve were devoid of endogenous IgG. These results suggest a possible nonspecific paracellular transport pathway between cytotrophoblast cells, which may conceivably contribute to the acquisition of passive immunity by the fetus, and offer a rational explanation for the presence of small quantities of maternal IgG in the amniotic fluid.

AB - Maternal immunoglobulin-G (IgG) is known to be transported across the placental syncytiotrophoblast during the period when the human fetus is incapable of manufacturing these defensive molecules. In this study we investigated the possible role of the amniochorion, that surrounds the amniotic cavity in which the fetus lies, in the transfer of immunoglobulin. Endogenous IgG was localised in the amniochorion by confocal immunofluorescence microscopy and by ultrastructural labelling of ultrathin frozen tissue sections using the protein A-gold technique. Immunoreactivity was identified in the extracellular matrix tissues and necrotic amniotic epithelial cells. Healthy amniotic epithelial cells and cytotrophoblast cells of the chorion laeve were devoid of endogenous IgG. These results suggest a possible nonspecific paracellular transport pathway between cytotrophoblast cells, which may conceivably contribute to the acquisition of passive immunity by the fetus, and offer a rational explanation for the presence of small quantities of maternal IgG in the amniotic fluid.

KW - PLACENTA

KW - AMNIOCHORION

KW - CYTOTROPHOBLAST CELLS

KW - IMMUNOGLOBULIN-G

KW - IMMUNOCYTOCHEMISTRY

KW - HUMAN

KW - ULTRATHIN FROZEN-SECTIONS

KW - PLACENTAL-TRANSFER

KW - IGG SUBCLASSES

U2 - 10.1007/BF00583405

DO - 10.1007/BF00583405

M3 - Journal article

VL - 281

SP - 367

EP - 374

JO - Cell and Tissue Research

JF - Cell and Tissue Research

SN - 0302-766X

IS - 2

ER -

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