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  • CARBPOL-S-17-02791

    Rights statement: This is the author’s version of a work that was accepted for publication in Carbohydrate Polymers. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Carbohydrate Polymers, 182, 2018 DOI: 10.1016/j.carbpol.2017.11.016

    Accepted author manuscript, 1.16 MB, PDF document

    Available under license: CC BY-NC-ND

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Ulvan-chitosan polyelectrolyte complexes as matrices for enzyme induced biomimetic mineralization

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Published
  • Mamoni Dash
  • Sangram K. Samal
  • Andrea Morelli
  • Cristina Bartoli
  • Heidi A. Declercq
  • Timothy E.L. Douglas
  • Peter Dubruel
  • Federica Chiellini
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<mark>Journal publication date</mark>15/02/2018
<mark>Journal</mark>Carbohydrate Polymers
Volume182
Number of pages11
Pages (from-to)254-264
Publication StatusPublished
Early online date3/11/17
<mark>Original language</mark>English

Abstract

Polyelectrolyte complexes (PEC) of chitosan and ulvan were fabricated to study alkaline phosphatase (ALP) mediated formation of apatitic minerals. Scaffolds of the PEC were subjected to ALP and successful mineral formation was studied using SEM, Raman and XRD techniques. Investigation of the morphology via SEM shows globular structures of the deposited minerals, which promoted cell attachment, proliferation and extracellular matrix formation. The PEC and their successful calcium phosphate based mineralization offers a greener route of scaffold fabrication towards developing resorbable materials for tissue engineering.

Bibliographic note

This is the author’s version of a work that was accepted for publication in Carbohydrate Polymers. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Carbohydrate Polymers, 182, 2018 DOI: 10.1016/j.carbpol.2017.11.016