Rights statement: This is the author’s version of a work that was accepted for publication in Carbohydrate Polymers. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Carbohydrate Polymers, 182, 2018 DOI: 10.1016/j.carbpol.2017.11.016
Accepted author manuscript, 1.16 MB, PDF document
Available under license: CC BY-NC-ND
Final published version
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - Ulvan-chitosan polyelectrolyte complexes as matrices for enzyme induced biomimetic mineralization
AU - Dash, Mamoni
AU - Samal, Sangram K.
AU - Morelli, Andrea
AU - Bartoli, Cristina
AU - Declercq, Heidi A.
AU - Douglas, Timothy E.L.
AU - Dubruel, Peter
AU - Chiellini, Federica
N1 - This is the author’s version of a work that was accepted for publication in Carbohydrate Polymers. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Carbohydrate Polymers, 182, 2018 DOI: 10.1016/j.carbpol.2017.11.016
PY - 2018/2/15
Y1 - 2018/2/15
N2 - Polyelectrolyte complexes (PEC) of chitosan and ulvan were fabricated to study alkaline phosphatase (ALP) mediated formation of apatitic minerals. Scaffolds of the PEC were subjected to ALP and successful mineral formation was studied using SEM, Raman and XRD techniques. Investigation of the morphology via SEM shows globular structures of the deposited minerals, which promoted cell attachment, proliferation and extracellular matrix formation. The PEC and their successful calcium phosphate based mineralization offers a greener route of scaffold fabrication towards developing resorbable materials for tissue engineering.
AB - Polyelectrolyte complexes (PEC) of chitosan and ulvan were fabricated to study alkaline phosphatase (ALP) mediated formation of apatitic minerals. Scaffolds of the PEC were subjected to ALP and successful mineral formation was studied using SEM, Raman and XRD techniques. Investigation of the morphology via SEM shows globular structures of the deposited minerals, which promoted cell attachment, proliferation and extracellular matrix formation. The PEC and their successful calcium phosphate based mineralization offers a greener route of scaffold fabrication towards developing resorbable materials for tissue engineering.
KW - Ulvan
KW - Chitosan
KW - Scaffolds
KW - Enzyme
KW - Biomimetic mineralization
KW - Alkaline phosphatase
KW - Polyelectrolyte complexes
U2 - 10.1016/j.carbpol.2017.11.016
DO - 10.1016/j.carbpol.2017.11.016
M3 - Journal article
VL - 182
SP - 254
EP - 264
JO - Carbohydrate Polymers
JF - Carbohydrate Polymers
SN - 0144-8617
ER -