During the last three decades, health organisations started to widely adopt information system (IS) to manage healthcare limitations and challenges. Lately, the spending on health information system (HIS) has continued to increase, and there has been a significant increase in the use of mobile technology, social media, wearables and online communities. Telemedicine is a subset of telehealth, specifically the provision of clinical and medical services to patients through technology such as audio, video conferencing, and text messaging. Hence, healthcare organisations have attempted to generate the maximum value out of the system by utilising it effectively. However, we have a limited understanding of the effective use of telemedicine applications from healthcare providers’ and patients’ perspectives. Previous studies have focused on the implication of HIS use and its impacts on entire healthcare organisations’ performances or users’ satisfaction. Also, these studies have been restricted to focus on the healthcare providers’ perspectives, neglecting other perspectives (such as the patients’). Therefore, this paper seeks to explore what the effective use of telemedicine applications is and what it constitutes from the healthcare providers’ and patients’ perspectives. This research is in progress; both qualitative and quantitative data will be analysed to conceptualise a holistic notion on the effective use of telemedicine