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Understanding the Form of the Input pressure of Focused Ultrasound in the Rayleigh-Plesset Equation to Improve Drug Delivery Efficiency

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Understanding the Form of the Input pressure of Focused Ultrasound in the Rayleigh-Plesset Equation to Improve Drug Delivery Efficiency. / Peng, Q.; Rottschäfer, Vivi.
Computer Methods in Biomechanics and Biomedical Engineering II: Selected Papers from the 18th International Symposium CMBBE 2023, May 3-5, 2023, Paris, France. ed. / Wafa Skalli; Sébastien Laporte; Aurélie Benoit. Cham: Springer, 2024. p. 280-288 (Lecture Notes in Computational Vision and Biomechanics; Vol. 39).

Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Conference contribution/Paper › peer-review

Harvard

Peng, Q & Rottschäfer, V 2024, Understanding the Form of the Input pressure of Focused Ultrasound in the Rayleigh-Plesset Equation to Improve Drug Delivery Efficiency. in W Skalli, S Laporte & A Benoit (eds), Computer Methods in Biomechanics and Biomedical Engineering II: Selected Papers from the 18th International Symposium CMBBE 2023, May 3-5, 2023, Paris, France. Lecture Notes in Computational Vision and Biomechanics, vol. 39, Springer, Cham, pp. 280-288. https://doi.org/10.1007/978-3-031-55315-8_31

APA

Peng, Q., & Rottschäfer, V. (2024). Understanding the Form of the Input pressure of Focused Ultrasound in the Rayleigh-Plesset Equation to Improve Drug Delivery Efficiency. In W. Skalli, S. Laporte, & A. Benoit (Eds.), Computer Methods in Biomechanics and Biomedical Engineering II: Selected Papers from the 18th International Symposium CMBBE 2023, May 3-5, 2023, Paris, France (pp. 280-288). (Lecture Notes in Computational Vision and Biomechanics; Vol. 39). Springer. https://doi.org/10.1007/978-3-031-55315-8_31

Vancouver

Peng Q, Rottschäfer V. Understanding the Form of the Input pressure of Focused Ultrasound in the Rayleigh-Plesset Equation to Improve Drug Delivery Efficiency. In Skalli W, Laporte S, Benoit A, editors, Computer Methods in Biomechanics and Biomedical Engineering II: Selected Papers from the 18th International Symposium CMBBE 2023, May 3-5, 2023, Paris, France. Cham: Springer. 2024. p. 280-288. (Lecture Notes in Computational Vision and Biomechanics). Epub 2023 May 3. doi: 10.1007/978-3-031-55315-8_31

Author

Peng, Q. ; Rottschäfer, Vivi. / Understanding the Form of the Input pressure of Focused Ultrasound in the Rayleigh-Plesset Equation to Improve Drug Delivery Efficiency. Computer Methods in Biomechanics and Biomedical Engineering II: Selected Papers from the 18th International Symposium CMBBE 2023, May 3-5, 2023, Paris, France. editor / Wafa Skalli ; Sébastien Laporte ; Aurélie Benoit. Cham : Springer, 2024. pp. 280-288 (Lecture Notes in Computational Vision and Biomechanics).

Bibtex

@inproceedings{ef388041a672491cbfb8eaed7386c56f,
title = "Understanding the Form of the Input pressure of Focused Ultrasound in the Rayleigh-Plesset Equation to Improve Drug Delivery Efficiency",
abstract = "To improve the drug delivery efficiency in the brain, the combination of the focused ultrasound (FUS) with microbubbles (MBs) shows a great potential to increase the permeability of the blood-brain barrier (BBB). The Rayleigh-Plesset equation is widely used to describe the dynamics of the MB, however, it is not clear what the most promising form of the FUS should be. In this manuscript, we investigate the choice of the input pressure of the FUS, both from analytical and numerical perspective. Furthermore, sensitivity tests are conducted to investigate the relations between the oscillation of the MB and the parameters. We conclude that the average of the FUS should lie at zero, since the MB must expand compared to its initial radius to release the drug molecules.",
author = "Q. Peng and Vivi Rottsch{\"a}fer",
year = "2024",
month = apr,
day = "24",
doi = "10.1007/978-3-031-55315-8_31",
language = "English",
isbn = "9783031553141",
series = "Lecture Notes in Computational Vision and Biomechanics",
publisher = "Springer",
pages = "280--288",
editor = "Wafa Skalli and Laporte, {S{\'e}bastien } and Aur{\'e}lie Benoit",
booktitle = "Computer Methods in Biomechanics and Biomedical Engineering II",

}

RIS

TY - GEN

T1 - Understanding the Form of the Input pressure of Focused Ultrasound in the Rayleigh-Plesset Equation to Improve Drug Delivery Efficiency

AU - Peng, Q.

AU - Rottschäfer, Vivi

PY - 2024/4/24

Y1 - 2024/4/24

N2 - To improve the drug delivery efficiency in the brain, the combination of the focused ultrasound (FUS) with microbubbles (MBs) shows a great potential to increase the permeability of the blood-brain barrier (BBB). The Rayleigh-Plesset equation is widely used to describe the dynamics of the MB, however, it is not clear what the most promising form of the FUS should be. In this manuscript, we investigate the choice of the input pressure of the FUS, both from analytical and numerical perspective. Furthermore, sensitivity tests are conducted to investigate the relations between the oscillation of the MB and the parameters. We conclude that the average of the FUS should lie at zero, since the MB must expand compared to its initial radius to release the drug molecules.

AB - To improve the drug delivery efficiency in the brain, the combination of the focused ultrasound (FUS) with microbubbles (MBs) shows a great potential to increase the permeability of the blood-brain barrier (BBB). The Rayleigh-Plesset equation is widely used to describe the dynamics of the MB, however, it is not clear what the most promising form of the FUS should be. In this manuscript, we investigate the choice of the input pressure of the FUS, both from analytical and numerical perspective. Furthermore, sensitivity tests are conducted to investigate the relations between the oscillation of the MB and the parameters. We conclude that the average of the FUS should lie at zero, since the MB must expand compared to its initial radius to release the drug molecules.

U2 - 10.1007/978-3-031-55315-8_31

DO - 10.1007/978-3-031-55315-8_31

M3 - Conference contribution/Paper

SN - 9783031553141

T3 - Lecture Notes in Computational Vision and Biomechanics

SP - 280

EP - 288

BT - Computer Methods in Biomechanics and Biomedical Engineering II

A2 - Skalli, Wafa

A2 - Laporte, Sébastien

A2 - Benoit, Aurélie

PB - Springer

CY - Cham

ER -