Final published version
Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Conference contribution/Paper › peer-review
Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Conference contribution/Paper › peer-review
}
TY - GEN
T1 - Understanding the Form of the Input pressure of Focused Ultrasound in the Rayleigh-Plesset Equation to Improve Drug Delivery Efficiency
AU - Peng, Q.
AU - Rottschäfer, Vivi
PY - 2024/4/24
Y1 - 2024/4/24
N2 - To improve the drug delivery efficiency in the brain, the combination of the focused ultrasound (FUS) with microbubbles (MBs) shows a great potential to increase the permeability of the blood-brain barrier (BBB). The Rayleigh-Plesset equation is widely used to describe the dynamics of the MB, however, it is not clear what the most promising form of the FUS should be. In this manuscript, we investigate the choice of the input pressure of the FUS, both from analytical and numerical perspective. Furthermore, sensitivity tests are conducted to investigate the relations between the oscillation of the MB and the parameters. We conclude that the average of the FUS should lie at zero, since the MB must expand compared to its initial radius to release the drug molecules.
AB - To improve the drug delivery efficiency in the brain, the combination of the focused ultrasound (FUS) with microbubbles (MBs) shows a great potential to increase the permeability of the blood-brain barrier (BBB). The Rayleigh-Plesset equation is widely used to describe the dynamics of the MB, however, it is not clear what the most promising form of the FUS should be. In this manuscript, we investigate the choice of the input pressure of the FUS, both from analytical and numerical perspective. Furthermore, sensitivity tests are conducted to investigate the relations between the oscillation of the MB and the parameters. We conclude that the average of the FUS should lie at zero, since the MB must expand compared to its initial radius to release the drug molecules.
U2 - 10.1007/978-3-031-55315-8_31
DO - 10.1007/978-3-031-55315-8_31
M3 - Conference contribution/Paper
SN - 9783031553141
T3 - Lecture Notes in Computational Vision and Biomechanics
SP - 280
EP - 288
BT - Computer Methods in Biomechanics and Biomedical Engineering II
A2 - Skalli, Wafa
A2 - Laporte, Sébastien
A2 - Benoit, Aurélie
PB - Springer
CY - Cham
ER -