TY - JOUR

T1 - Using ESPEN data for evidence-based control of neglected tropical diseases in sub-Saharan Africa

T2 - A comprehensive model-based geostatistical analysis of soil-transmitted helminths

AU - Khaki, Jessie Jane

AU - Minnery, Mark

AU - Giorgi, Emanuele

PY - 2025/1/9

Y1 - 2025/1/9

N2 - The Expanded Special Project for the Elimination of Neglected Tropical Diseases (ESPEN) was launched in 2019 by the World Health Organization and African nations to combat Neglected Tropical Diseases (NTDs), including Soil-transmitted helminths (STH), which still affect over 1.5 billion people globally. In this study, we present a comprehensive geostatistical analysis of publicly available STH survey data from ESPEN to delineate inter-country disparities in STH prevalence and its environmental drivers while highlighting the strengths and limitations that arise from the use of the ESPEN data. To achieve this, we also propose the use of calibration validation methods to assess the suitability of geostatistical models for disease mapping at the national scale. We analysed the most recent survey data with at least 50 geo-referenced observations, and modelled each STH species data (hookworm, roundworm, whipworm) separately. Binomial geostatistical models were developed for each country, exploring associations between STH and environmental covariates, and were validated using the non-randomized probability integral transform. We produced pixel-, subnational-, and country-level prevalence maps for successfully calibrated countries. All the results were made publicly available through an R Shiny application. Among 35 countries with STH data that met our inclusion criteria, the reported data years ranged from 2004 to 2018. Models from 25 countries were found to be well-calibrated. Spatial patterns exhibited significant variation in STH species distribution and heterogeneity in spatial correlation scale (1.14 km to 3,027.44 km) and residual spatial variation variance across countries. This study highlights the utility of ESPEN data in assessing spatial variations in STH prevalence across countries using model-based geostatistics. Despite the challenges posed by data sparsity which limit the application of geostatistical models, the insights gained remain crucial for directing focused interventions and shaping future STH assessment strategies within national control programs.

AB - The Expanded Special Project for the Elimination of Neglected Tropical Diseases (ESPEN) was launched in 2019 by the World Health Organization and African nations to combat Neglected Tropical Diseases (NTDs), including Soil-transmitted helminths (STH), which still affect over 1.5 billion people globally. In this study, we present a comprehensive geostatistical analysis of publicly available STH survey data from ESPEN to delineate inter-country disparities in STH prevalence and its environmental drivers while highlighting the strengths and limitations that arise from the use of the ESPEN data. To achieve this, we also propose the use of calibration validation methods to assess the suitability of geostatistical models for disease mapping at the national scale. We analysed the most recent survey data with at least 50 geo-referenced observations, and modelled each STH species data (hookworm, roundworm, whipworm) separately. Binomial geostatistical models were developed for each country, exploring associations between STH and environmental covariates, and were validated using the non-randomized probability integral transform. We produced pixel-, subnational-, and country-level prevalence maps for successfully calibrated countries. All the results were made publicly available through an R Shiny application. Among 35 countries with STH data that met our inclusion criteria, the reported data years ranged from 2004 to 2018. Models from 25 countries were found to be well-calibrated. Spatial patterns exhibited significant variation in STH species distribution and heterogeneity in spatial correlation scale (1.14 km to 3,027.44 km) and residual spatial variation variance across countries. This study highlights the utility of ESPEN data in assessing spatial variations in STH prevalence across countries using model-based geostatistics. Despite the challenges posed by data sparsity which limit the application of geostatistical models, the insights gained remain crucial for directing focused interventions and shaping future STH assessment strategies within national control programs.

KW - Helminths - classification - isolation & purification

KW - Neglected Diseases - epidemiology - prevention & control

KW - Models, Statistical

KW - Humans

KW - Animals

KW - Helminthiasis - epidemiology - prevention & control - transmission

KW - Soil - parasitology

KW - Africa South of the Sahara - epidemiology

KW - Tropical Medicine

KW - Prevalence

U2 - 10.1371/journal.pntd.0012782

DO - 10.1371/journal.pntd.0012782

M3 - Journal article

C2 - 39787255

VL - 19

JO - PLoS Neglected Tropical Diseases

JF - PLoS Neglected Tropical Diseases

SN - 1935-2727

IS - 1

M1 - e0012782

ER -