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    Rights statement: This is a pre-copy-editing, author-produced PDF of an article accepted for publication in International Journal of Epidemiology following peer review. The definitive publisher-authenticated version Dmitry Shungin, ... [et. al]. Using genetics to test the causal relationship of total adiposity and periodontitis: Mendelian randomization analyses in the Gene-Lifestyle Interactions and Dental Endpoints (GLIDE) Consortium Int. J. Epidemiol. (2015) 44 (2): 638-650 doi:10.1093/ije/dyv075 is available online at: http://ije.oxfordjournals.org/content/44/2/638.abstract

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Using genetics to test the causal relationship of total adiposity and periodontitis: Mendelian randomization analyses in the Gene-Lifestyle Interactions and Dental Endpoints (GLIDE) Consortium

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Using genetics to test the causal relationship of total adiposity and periodontitis: Mendelian randomization analyses in the Gene-Lifestyle Interactions and Dental Endpoints (GLIDE) Consortium. / Shungin, Dmitry; Cornelis, Marilyn C.; Divaris, Kimon et al.

In: International Journal of Epidemiology, Vol. 44, No. 2, 2015, p. 638-650.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Shungin, D, Cornelis, MC, Divaris, K, Holtfreter, B, Shaffer, JR, Yu, Y-H, Barros, SP, Beck, JD, Biffar, R, Boerwinkle, EA, Crout, RJ, Ganna, A, Hallmans, G, Hindy, G, Hu, FB, Kraft, P, McNeil, DW, Melander, O, Moss, KL, North, KE, Orho-Melander, M, Pedersen, NL, Ridker, PM, Rimm, EB, Rose, LM, Rukh, G, Teumer, A, Weyant, RJ, Chasman, DI, Joshipura, K, Kocher, T, Magnusson, PKE, Marazita, ML, Nilsson, P, Offenbacher, S, Davey Smith, G, Lundberg, P, Palmer, TM, Timpson, NJ, Johansson, I & Franks, PW 2015, 'Using genetics to test the causal relationship of total adiposity and periodontitis: Mendelian randomization analyses in the Gene-Lifestyle Interactions and Dental Endpoints (GLIDE) Consortium', International Journal of Epidemiology, vol. 44, no. 2, pp. 638-650. https://doi.org/10.1093/ije/dyv075

APA

Shungin, D., Cornelis, M. C., Divaris, K., Holtfreter, B., Shaffer, J. R., Yu, Y-H., Barros, S. P., Beck, J. D., Biffar, R., Boerwinkle, E. A., Crout, R. J., Ganna, A., Hallmans, G., Hindy, G., Hu, F. B., Kraft, P., McNeil, D. W., Melander, O., Moss, K. L., ... Franks, P. W. (2015). Using genetics to test the causal relationship of total adiposity and periodontitis: Mendelian randomization analyses in the Gene-Lifestyle Interactions and Dental Endpoints (GLIDE) Consortium. International Journal of Epidemiology, 44(2), 638-650. https://doi.org/10.1093/ije/dyv075

Vancouver

Shungin D, Cornelis MC, Divaris K, Holtfreter B, Shaffer JR, Yu Y-H et al. Using genetics to test the causal relationship of total adiposity and periodontitis: Mendelian randomization analyses in the Gene-Lifestyle Interactions and Dental Endpoints (GLIDE) Consortium. International Journal of Epidemiology. 2015;44(2):638-650. Epub 2015 Jun 6. doi: 10.1093/ije/dyv075

Author

Shungin, Dmitry ; Cornelis, Marilyn C. ; Divaris, Kimon et al. / Using genetics to test the causal relationship of total adiposity and periodontitis: Mendelian randomization analyses in the Gene-Lifestyle Interactions and Dental Endpoints (GLIDE) Consortium. In: International Journal of Epidemiology. 2015 ; Vol. 44, No. 2. pp. 638-650.

Bibtex

@article{294ef018ad944af09ec99fc5d4ab824a,
title = "Using genetics to test the causal relationship of total adiposity and periodontitis: Mendelian randomization analyses in the Gene-Lifestyle Interactions and Dental Endpoints (GLIDE) Consortium",
abstract = "Background: The observational relationship between obesity and periodontitis is widely known, yet causal evidence is lacking. Our objective was to investigate causal associations between periodontitis and body mass index (BMI).Methods: We performed Mendelian randomization analyses with BMI-associated loci combined in a genetic risk score (GRS) as the instrument for BMI. All analyses were conducted within the Gene-Lifestyle Interactions and Dental Endpoints (GLIDE) Consortium in 13 studies from Europe and the USA, including 49 066 participants with clinically assessed (seven studies, 42.1% of participants) and self-reported (six studies, 57.9% of participants) periodontitis and genotype data (17 672/31 394 with/without periodontitis); 68 761 participants with BMI and genotype data; and 57 871 participants (18 881/38 990 with/without periodontitis) with data on BMI and periodontitis.Results: In the observational meta-analysis of all participants, the pooled crude observational odds ratio (OR) for periodontitis was 1.13 [95% confidence interval (CI): 1.03, 1.24] per standard deviation increase of BMI. Controlling for potential confounders attenuated this estimate (OR = 1.08; 95% CI:1.03, 1.12). For clinically assessed periodontitis, corresponding ORs were 1.25 (95% CI: 1.10, 1.42) and 1.13 (95% CI: 1.10, 1.17), respectively. In the genetic association meta-analysis, the OR for periodontitis was 1.01 (95% CI: 0.99, 1.03) per GRS unit (per one effect allele) in all participants and 1.00 (95% CI: 0.97, 1.03) in participants with clinically assessed periodontitis. The instrumental variable meta-analysis of all participants yielded an OR of 1.05 (95% CI: 0.80, 1.38) per BMI standard deviation, and 0.90 (95% CI: 0.56, 1.46) in participants with clinical data.Conclusions: Our study does not support total adiposity as a causal risk factor for periodontitis, as the point estimate is very close to the null in the causal inference analysis, with wide confidence intervals.",
keywords = "Mendelian randomization, BMI, periodontitis, casual inference, confounding",
author = "Dmitry Shungin and Cornelis, {Marilyn C.} and Kimon Divaris and Birte Holtfreter and Shaffer, {John R.} and Yau-Hua Yu and Barros, {Silvana P} and Beck, {James D.} and Reiner Biffar and Boerwinkle, {Eric A.} and Crout, {Richard J.} and Andrea Ganna and Goran Hallmans and George Hindy and Hu, {Frank B.} and Peter Kraft and McNeil, {Daniel W.} and Olle Melander and Moss, {Kevin L.} and North, {Kari E.} and Marju Orho-Melander and Pedersen, {Nancy L.} and Ridker, {Paul M.} and Rimm, {Eric B.} and Rose, {Lynda M.} and Gull Rukh and Alexander Teumer and Weyant, {Robert J.} and Chasman, {Daniel I.} and Kaumudi Joshipura and Thomas Kocher and Magnusson, {Patrik K. E.} and Marazita, {Mary L.} and Peter Nilsson and Steve Offenbacher and {Davey Smith}, George and Pernilla Lundberg and Palmer, {Tom M.} and Timpson, {Nicholas J.} and Ingegerd Johansson and Franks, {Paul W.}",
note = "This is a pre-copy-editing, author-produced PDF of an article accepted for publication in International Journal of Epidemiology following peer review. The definitive publisher-authenticated version Dmitry Shungin, Marilyn C Cornelis, Kimon Divaris, Birte Holtfreter, John R Shaffer, Yau-Hua Yu, Silvana P Barros, James D Beck, Reiner Biffar, Eric A Boerwinkle, Richard J. Crout, Andrea Ganna, Goran Hallmans, George Hindy, Frank B Hu, Peter Kraft, Daniel W McNeil, Olle Melander, Kevin L Moss, Kari E North, Marju Orho-Melander, Nancy L Pedersen, Paul M Ridker, Eric B Rimm, Lynda M Rose, Gull Rukh, Alexander Teumer, Robert J Weyant, Daniel I Chasman, Kaumudi Joshipura, Thomas Kocher, Patrik KE Magnusson, Mary L Marazita, Peter Nilsson, Steve Offenbacher, George Davey Smith, Pernilla Lundberg, Tom M Palmer, Nicholas J Timpson, Ingegerd Johansson, and Paul W Franks Using genetics to test the causal relationship of total adiposity and periodontitis: Mendelian randomization analyses in the Gene-Lifestyle Interactions and Dental Endpoints (GLIDE) Consortium Int. J. Epidemiol. (2015) 44 (2): 638-650 doi:10.1093/ije/dyv075 is available online at: http://ije.oxfordjournals.org/content/44/2/638.abstract",
year = "2015",
doi = "10.1093/ije/dyv075",
language = "English",
volume = "44",
pages = "638--650",
journal = "International Journal of Epidemiology",
issn = "0300-5771",
publisher = "NLM (Medline)",
number = "2",

}

RIS

TY - JOUR

T1 - Using genetics to test the causal relationship of total adiposity and periodontitis: Mendelian randomization analyses in the Gene-Lifestyle Interactions and Dental Endpoints (GLIDE) Consortium

AU - Shungin, Dmitry

AU - Cornelis, Marilyn C.

AU - Divaris, Kimon

AU - Holtfreter, Birte

AU - Shaffer, John R.

AU - Yu, Yau-Hua

AU - Barros, Silvana P

AU - Beck, James D.

AU - Biffar, Reiner

AU - Boerwinkle, Eric A.

AU - Crout, Richard J.

AU - Ganna, Andrea

AU - Hallmans, Goran

AU - Hindy, George

AU - Hu, Frank B.

AU - Kraft, Peter

AU - McNeil, Daniel W.

AU - Melander, Olle

AU - Moss, Kevin L.

AU - North, Kari E.

AU - Orho-Melander, Marju

AU - Pedersen, Nancy L.

AU - Ridker, Paul M.

AU - Rimm, Eric B.

AU - Rose, Lynda M.

AU - Rukh, Gull

AU - Teumer, Alexander

AU - Weyant, Robert J.

AU - Chasman, Daniel I.

AU - Joshipura, Kaumudi

AU - Kocher, Thomas

AU - Magnusson, Patrik K. E.

AU - Marazita, Mary L.

AU - Nilsson, Peter

AU - Offenbacher, Steve

AU - Davey Smith, George

AU - Lundberg, Pernilla

AU - Palmer, Tom M.

AU - Timpson, Nicholas J.

AU - Johansson, Ingegerd

AU - Franks, Paul W.

N1 - This is a pre-copy-editing, author-produced PDF of an article accepted for publication in International Journal of Epidemiology following peer review. The definitive publisher-authenticated version Dmitry Shungin, Marilyn C Cornelis, Kimon Divaris, Birte Holtfreter, John R Shaffer, Yau-Hua Yu, Silvana P Barros, James D Beck, Reiner Biffar, Eric A Boerwinkle, Richard J. Crout, Andrea Ganna, Goran Hallmans, George Hindy, Frank B Hu, Peter Kraft, Daniel W McNeil, Olle Melander, Kevin L Moss, Kari E North, Marju Orho-Melander, Nancy L Pedersen, Paul M Ridker, Eric B Rimm, Lynda M Rose, Gull Rukh, Alexander Teumer, Robert J Weyant, Daniel I Chasman, Kaumudi Joshipura, Thomas Kocher, Patrik KE Magnusson, Mary L Marazita, Peter Nilsson, Steve Offenbacher, George Davey Smith, Pernilla Lundberg, Tom M Palmer, Nicholas J Timpson, Ingegerd Johansson, and Paul W Franks Using genetics to test the causal relationship of total adiposity and periodontitis: Mendelian randomization analyses in the Gene-Lifestyle Interactions and Dental Endpoints (GLIDE) Consortium Int. J. Epidemiol. (2015) 44 (2): 638-650 doi:10.1093/ije/dyv075 is available online at: http://ije.oxfordjournals.org/content/44/2/638.abstract

PY - 2015

Y1 - 2015

N2 - Background: The observational relationship between obesity and periodontitis is widely known, yet causal evidence is lacking. Our objective was to investigate causal associations between periodontitis and body mass index (BMI).Methods: We performed Mendelian randomization analyses with BMI-associated loci combined in a genetic risk score (GRS) as the instrument for BMI. All analyses were conducted within the Gene-Lifestyle Interactions and Dental Endpoints (GLIDE) Consortium in 13 studies from Europe and the USA, including 49 066 participants with clinically assessed (seven studies, 42.1% of participants) and self-reported (six studies, 57.9% of participants) periodontitis and genotype data (17 672/31 394 with/without periodontitis); 68 761 participants with BMI and genotype data; and 57 871 participants (18 881/38 990 with/without periodontitis) with data on BMI and periodontitis.Results: In the observational meta-analysis of all participants, the pooled crude observational odds ratio (OR) for periodontitis was 1.13 [95% confidence interval (CI): 1.03, 1.24] per standard deviation increase of BMI. Controlling for potential confounders attenuated this estimate (OR = 1.08; 95% CI:1.03, 1.12). For clinically assessed periodontitis, corresponding ORs were 1.25 (95% CI: 1.10, 1.42) and 1.13 (95% CI: 1.10, 1.17), respectively. In the genetic association meta-analysis, the OR for periodontitis was 1.01 (95% CI: 0.99, 1.03) per GRS unit (per one effect allele) in all participants and 1.00 (95% CI: 0.97, 1.03) in participants with clinically assessed periodontitis. The instrumental variable meta-analysis of all participants yielded an OR of 1.05 (95% CI: 0.80, 1.38) per BMI standard deviation, and 0.90 (95% CI: 0.56, 1.46) in participants with clinical data.Conclusions: Our study does not support total adiposity as a causal risk factor for periodontitis, as the point estimate is very close to the null in the causal inference analysis, with wide confidence intervals.

AB - Background: The observational relationship between obesity and periodontitis is widely known, yet causal evidence is lacking. Our objective was to investigate causal associations between periodontitis and body mass index (BMI).Methods: We performed Mendelian randomization analyses with BMI-associated loci combined in a genetic risk score (GRS) as the instrument for BMI. All analyses were conducted within the Gene-Lifestyle Interactions and Dental Endpoints (GLIDE) Consortium in 13 studies from Europe and the USA, including 49 066 participants with clinically assessed (seven studies, 42.1% of participants) and self-reported (six studies, 57.9% of participants) periodontitis and genotype data (17 672/31 394 with/without periodontitis); 68 761 participants with BMI and genotype data; and 57 871 participants (18 881/38 990 with/without periodontitis) with data on BMI and periodontitis.Results: In the observational meta-analysis of all participants, the pooled crude observational odds ratio (OR) for periodontitis was 1.13 [95% confidence interval (CI): 1.03, 1.24] per standard deviation increase of BMI. Controlling for potential confounders attenuated this estimate (OR = 1.08; 95% CI:1.03, 1.12). For clinically assessed periodontitis, corresponding ORs were 1.25 (95% CI: 1.10, 1.42) and 1.13 (95% CI: 1.10, 1.17), respectively. In the genetic association meta-analysis, the OR for periodontitis was 1.01 (95% CI: 0.99, 1.03) per GRS unit (per one effect allele) in all participants and 1.00 (95% CI: 0.97, 1.03) in participants with clinically assessed periodontitis. The instrumental variable meta-analysis of all participants yielded an OR of 1.05 (95% CI: 0.80, 1.38) per BMI standard deviation, and 0.90 (95% CI: 0.56, 1.46) in participants with clinical data.Conclusions: Our study does not support total adiposity as a causal risk factor for periodontitis, as the point estimate is very close to the null in the causal inference analysis, with wide confidence intervals.

KW - Mendelian randomization

KW - BMI

KW - periodontitis

KW - casual inference

KW - confounding

U2 - 10.1093/ije/dyv075

DO - 10.1093/ije/dyv075

M3 - Journal article

VL - 44

SP - 638

EP - 650

JO - International Journal of Epidemiology

JF - International Journal of Epidemiology

SN - 0300-5771

IS - 2

ER -