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    Rights statement: Preprint of an article published in Journal of Micromechanics and Molecular Physics, Volume, Issue, Year, Pages] 10.1142/S2424913020500125 © World Scientific Publishing Company] https://www.worldscientific.com/doi/abs/10.1142/S2424913020500125

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Using hierarchical mesoporous Mg-Al LDH as a potential model to precisely load BSA for biological application

Research output: Contribution to journalJournal articlepeer-review

E-pub ahead of print
  • X. Li
  • L. Liang
  • Y. Tan
  • Q. Huang
  • S. Yang
  • Y. Tian
  • J. Zhou
  • H. Wu
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<mark>Journal publication date</mark>24/05/2021
<mark>Journal</mark>Journal of Micromechanics and Molecular Physics
Publication StatusE-pub ahead of print
Early online date24/05/21
<mark>Original language</mark>English

Abstract

Bovine serum albumin (BSA) is a familiar protein and often used as a model drug to test the adsorption efficiency of material, while the cytotoxicity of hybrid is overlooked. In this study, we synthesized hierarchical mesoporous flower-like Mg-Al layered double hydroxide (LDH) microspheres through anion surfactant mediated hydrothermal method. The scanning electron microscopic images demonstrated that 10S-LDH and 100S-LDH samples possessed a porous surface and the porosity structure were affected by the concentration of anionic surfactant, i.e., sodium dodecyl sulfonate (SDS). By being immersed in the BSA/phosphate buffer solution (PBS) solution, the 100S-LDH had a loading capacity about 44.6 mg/g. Compared to 1S-LDH and 10S-LDH, the SDS intercalated in 100S-LDH could form the hydrogen bond with BSA molecules and promote the adsorption efficiency. In the cytotoxicity test towards Raw264.7 cells, the hybrid of BSA and xS-LDH showed a superior biocompatibility to the raw LDH materials. The SDS intercalated Mg-Al LDH is expected to be used in the bioactive molecules delivery. © World Scientific Publishing Company

Bibliographic note

Preprint of an article published in Journal of Micromechanics and Molecular Physics, Volume, Issue, Year, Pages] 10.1142/S2424913020500125 © World Scientific Publishing Company] https://www.worldscientific.com/doi/abs/10.1142/S2424913020500125