Rights statement: Preprint of an article published in Journal of Micromechanics and Molecular Physics, 5, 4, 2020, 2050012 10.1142/S2424913020500125 © World Scientific Publishing Company] https://www.worldscientific.com/doi/abs/10.1142/S2424913020500125
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Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - Using hierarchical mesoporous Mg-Al LDH as a potential model to precisely load BSA for biological application
AU - Li, X.
AU - Liang, L.
AU - Tan, Y.
AU - Huang, Q.
AU - Yang, S.
AU - Tian, Y.
AU - Zhou, J.
AU - Wu, H.
N1 - Preprint of an article published in Journal of Micromechanics and Molecular Physics, 5, 4, 2020, 2050012 10.1142/S2424913020500125 © World Scientific Publishing Company] https://www.worldscientific.com/doi/abs/10.1142/S2424913020500125
PY - 2021/5/24
Y1 - 2021/5/24
N2 - Bovine serum albumin (BSA) is a familiar protein and often used as a model drug to test the adsorption efficiency of material, while the cytotoxicity of hybrid is overlooked. In this study, we synthesized hierarchical mesoporous flower-like Mg-Al layered double hydroxide (LDH) microspheres through anion surfactant mediated hydrothermal method. The scanning electron microscopic images demonstrated that 10S-LDH and 100S-LDH samples possessed a porous surface and the porosity structure were affected by the concentration of anionic surfactant, i.e., sodium dodecyl sulfonate (SDS). By being immersed in the BSA/phosphate buffer solution (PBS) solution, the 100S-LDH had a loading capacity about 44.6 mg/g. Compared to 1S-LDH and 10S-LDH, the SDS intercalated in 100S-LDH could form the hydrogen bond with BSA molecules and promote the adsorption efficiency. In the cytotoxicity test towards Raw264.7 cells, the hybrid of BSA and xS-LDH showed a superior biocompatibility to the raw LDH materials. The SDS intercalated Mg-Al LDH is expected to be used in the bioactive molecules delivery. © World Scientific Publishing Company
AB - Bovine serum albumin (BSA) is a familiar protein and often used as a model drug to test the adsorption efficiency of material, while the cytotoxicity of hybrid is overlooked. In this study, we synthesized hierarchical mesoporous flower-like Mg-Al layered double hydroxide (LDH) microspheres through anion surfactant mediated hydrothermal method. The scanning electron microscopic images demonstrated that 10S-LDH and 100S-LDH samples possessed a porous surface and the porosity structure were affected by the concentration of anionic surfactant, i.e., sodium dodecyl sulfonate (SDS). By being immersed in the BSA/phosphate buffer solution (PBS) solution, the 100S-LDH had a loading capacity about 44.6 mg/g. Compared to 1S-LDH and 10S-LDH, the SDS intercalated in 100S-LDH could form the hydrogen bond with BSA molecules and promote the adsorption efficiency. In the cytotoxicity test towards Raw264.7 cells, the hybrid of BSA and xS-LDH showed a superior biocompatibility to the raw LDH materials. The SDS intercalated Mg-Al LDH is expected to be used in the bioactive molecules delivery. © World Scientific Publishing Company
KW - Bioactive material
KW - BSA adsorption
KW - Cytotoxicity
KW - LDH
KW - SDS
U2 - 10.1142/S2424913020500125
DO - 10.1142/S2424913020500125
M3 - Journal article
VL - 5
JO - Journal of Micromechanics and Molecular Physics
JF - Journal of Micromechanics and Molecular Physics
SN - 2424-9130
IS - 4
M1 - 2050012
ER -