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Utilizing river and wastewater as a SARS-CoV-2 surveillance tool in settings with limited formal sewage systems

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Utilizing river and wastewater as a SARS-CoV-2 surveillance tool in settings with limited formal sewage systems. / Barnes, Kayla G.; Levy, Joshua I.; Gauld, Jillian et al.
In: Nature Communications, Vol. 14, No. 1, 7883, 30.11.2023.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Barnes, KG, Levy, JI, Gauld, J, Rigby, J, Kanjerwa, O, Uzzell, CB, Chilupsya, C, Anscombe, C, Tomkins-Tinch, C, Mbeti, O, Cairns, E, Thole, H, McSweeney, S, Chibwana, MG, Ashton, PM, Jere, KC, Meschke, JS, Diggle, P, Cornick, J, Chilima, B, Jambo, K, Andersen, KG, Kawalazira, G, Paterson, S, Nyirenda, TS & Feasey, N 2023, 'Utilizing river and wastewater as a SARS-CoV-2 surveillance tool in settings with limited formal sewage systems', Nature Communications, vol. 14, no. 1, 7883. https://doi.org/10.1038/s41467-023-43047-y

APA

Barnes, K. G., Levy, J. I., Gauld, J., Rigby, J., Kanjerwa, O., Uzzell, C. B., Chilupsya, C., Anscombe, C., Tomkins-Tinch, C., Mbeti, O., Cairns, E., Thole, H., McSweeney, S., Chibwana, M. G., Ashton, P. M., Jere, K. C., Meschke, J. S., Diggle, P., Cornick, J., ... Feasey, N. (2023). Utilizing river and wastewater as a SARS-CoV-2 surveillance tool in settings with limited formal sewage systems. Nature Communications, 14(1), Article 7883. https://doi.org/10.1038/s41467-023-43047-y

Vancouver

Barnes KG, Levy JI, Gauld J, Rigby J, Kanjerwa O, Uzzell CB et al. Utilizing river and wastewater as a SARS-CoV-2 surveillance tool in settings with limited formal sewage systems. Nature Communications. 2023 Nov 30;14(1):7883. doi: 10.1038/s41467-023-43047-y

Author

Barnes, Kayla G. ; Levy, Joshua I. ; Gauld, Jillian et al. / Utilizing river and wastewater as a SARS-CoV-2 surveillance tool in settings with limited formal sewage systems. In: Nature Communications. 2023 ; Vol. 14, No. 1.

Bibtex

@article{5b8442586f9e44a1b57961eb551ecedd,
title = "Utilizing river and wastewater as a SARS-CoV-2 surveillance tool in settings with limited formal sewage systems",
abstract = "The COVID-19 pandemic has profoundly impacted health systems globally and robust surveillance has been critical for pandemic control, however not all countries can currently sustain community pathogen surveillance programs. Wastewater surveillance has proven valuable in high-income settings, but less is known about the utility of water surveillance of pathogens in low-income countries. Here we show how wastewater surveillance of SAR-CoV-2 can be used to identify temporal changes and help determine circulating variants quickly. In Malawi, a country with limited community-based COVID-19 testing capacity, we explore the utility of rivers and wastewater for SARS-CoV-2 surveillance. From May 2020–May 2022, we collect water from up to 112 river or defunct wastewater treatment plant sites, detecting SARS-CoV-2 in 8.3% of samples. Peak SARS-CoV-2 detection in water samples predate peaks in clinical cases. Sequencing of water samples identified the Beta, Delta, and Omicron variants, with Delta and Omicron detected well in advance of detection in patients. Our work highlights how wastewater can be used to detect emerging waves, identify variants of concern, and provide an early warning system in settings with no formal sewage systems.",
author = "Barnes, {Kayla G.} and Levy, {Joshua I.} and Jillian Gauld and Jonathan Rigby and Oscar Kanjerwa and Uzzell, {Christopher B.} and Chisomo Chilupsya and Catherine Anscombe and Christopher Tomkins-Tinch and Omar Mbeti and Edward Cairns and Herbert Thole and Shannon McSweeney and Chibwana, {Marah G.} and Ashton, {Philip M.} and Jere, {Khuzwayo C.} and Meschke, {John Scott} and Peter Diggle and Jennifer Cornick and Benjamin Chilima and Kondwani Jambo and Andersen, {Kristian G.} and Gift Kawalazira and Steve Paterson and Nyirenda, {Tonney S.} and Nicholas Feasey",
year = "2023",
month = nov,
day = "30",
doi = "10.1038/s41467-023-43047-y",
language = "English",
volume = "14",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - Utilizing river and wastewater as a SARS-CoV-2 surveillance tool in settings with limited formal sewage systems

AU - Barnes, Kayla G.

AU - Levy, Joshua I.

AU - Gauld, Jillian

AU - Rigby, Jonathan

AU - Kanjerwa, Oscar

AU - Uzzell, Christopher B.

AU - Chilupsya, Chisomo

AU - Anscombe, Catherine

AU - Tomkins-Tinch, Christopher

AU - Mbeti, Omar

AU - Cairns, Edward

AU - Thole, Herbert

AU - McSweeney, Shannon

AU - Chibwana, Marah G.

AU - Ashton, Philip M.

AU - Jere, Khuzwayo C.

AU - Meschke, John Scott

AU - Diggle, Peter

AU - Cornick, Jennifer

AU - Chilima, Benjamin

AU - Jambo, Kondwani

AU - Andersen, Kristian G.

AU - Kawalazira, Gift

AU - Paterson, Steve

AU - Nyirenda, Tonney S.

AU - Feasey, Nicholas

PY - 2023/11/30

Y1 - 2023/11/30

N2 - The COVID-19 pandemic has profoundly impacted health systems globally and robust surveillance has been critical for pandemic control, however not all countries can currently sustain community pathogen surveillance programs. Wastewater surveillance has proven valuable in high-income settings, but less is known about the utility of water surveillance of pathogens in low-income countries. Here we show how wastewater surveillance of SAR-CoV-2 can be used to identify temporal changes and help determine circulating variants quickly. In Malawi, a country with limited community-based COVID-19 testing capacity, we explore the utility of rivers and wastewater for SARS-CoV-2 surveillance. From May 2020–May 2022, we collect water from up to 112 river or defunct wastewater treatment plant sites, detecting SARS-CoV-2 in 8.3% of samples. Peak SARS-CoV-2 detection in water samples predate peaks in clinical cases. Sequencing of water samples identified the Beta, Delta, and Omicron variants, with Delta and Omicron detected well in advance of detection in patients. Our work highlights how wastewater can be used to detect emerging waves, identify variants of concern, and provide an early warning system in settings with no formal sewage systems.

AB - The COVID-19 pandemic has profoundly impacted health systems globally and robust surveillance has been critical for pandemic control, however not all countries can currently sustain community pathogen surveillance programs. Wastewater surveillance has proven valuable in high-income settings, but less is known about the utility of water surveillance of pathogens in low-income countries. Here we show how wastewater surveillance of SAR-CoV-2 can be used to identify temporal changes and help determine circulating variants quickly. In Malawi, a country with limited community-based COVID-19 testing capacity, we explore the utility of rivers and wastewater for SARS-CoV-2 surveillance. From May 2020–May 2022, we collect water from up to 112 river or defunct wastewater treatment plant sites, detecting SARS-CoV-2 in 8.3% of samples. Peak SARS-CoV-2 detection in water samples predate peaks in clinical cases. Sequencing of water samples identified the Beta, Delta, and Omicron variants, with Delta and Omicron detected well in advance of detection in patients. Our work highlights how wastewater can be used to detect emerging waves, identify variants of concern, and provide an early warning system in settings with no formal sewage systems.

U2 - 10.1038/s41467-023-43047-y

DO - 10.1038/s41467-023-43047-y

M3 - Journal article

VL - 14

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 7883

ER -