Rights statement: This is the author’s version of a work that was accepted for publication in Cortex. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Cortex, 120, 2019 DOI: 10.1016/j.cortex.2019.06.012
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Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - Validity of irritability in Huntington's disease
T2 - A scoping review
AU - Simpson, Jane
AU - Dale, Maria
AU - Theed, Rachael
AU - Gunn, Sarah
AU - Zarotti, Nicolò
AU - Eccles, Fiona
N1 - This is the author’s version of a work that was accepted for publication in Cortex. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Cortex, 120, 2019 DOI: 10.1016/j.cortex.2019.06.012
PY - 2019/11/1
Y1 - 2019/11/1
N2 - PurposeTo scope the literature concerning irritability in Huntington’s disease to determine whether or not irritability is a valid and meaningful construct within this population.MethodA scoping literature review was conducted based on findings from a search of five databases (Academic Search Ultimate, PsycINFO, CINAHL, Scopus and Web of Science) in November 2018. From an initial return of 453 papers, 40 were found suitable for review.ResultsReview of the 40 studies highlighted several aspects of irritability in people with HD which influence its validity as an independent construct in context of the disease. While various measures are used to assess irritability, a gold standard has yet to be identified and consequently irritability is assessed inconsistently across the literature. In addition, the results suggest that irritability may not reflect pathological disease processes in HD, but rather comprises a multidimensional construct which appears to be strongly associated with other psychological difficulties such as depression and anxiety.ConclusionsThe current concept of irritability in people with HD continues to lack a general consensus in the clinical literature, in terms of both operationalisation and assessment. Consequently, further research is warranted in order to determine the extent to which irritability is a valid construct within the context of HD, including its associated behavioural, cognitive and affective dimensions.
AB - PurposeTo scope the literature concerning irritability in Huntington’s disease to determine whether or not irritability is a valid and meaningful construct within this population.MethodA scoping literature review was conducted based on findings from a search of five databases (Academic Search Ultimate, PsycINFO, CINAHL, Scopus and Web of Science) in November 2018. From an initial return of 453 papers, 40 were found suitable for review.ResultsReview of the 40 studies highlighted several aspects of irritability in people with HD which influence its validity as an independent construct in context of the disease. While various measures are used to assess irritability, a gold standard has yet to be identified and consequently irritability is assessed inconsistently across the literature. In addition, the results suggest that irritability may not reflect pathological disease processes in HD, but rather comprises a multidimensional construct which appears to be strongly associated with other psychological difficulties such as depression and anxiety.ConclusionsThe current concept of irritability in people with HD continues to lack a general consensus in the clinical literature, in terms of both operationalisation and assessment. Consequently, further research is warranted in order to determine the extent to which irritability is a valid construct within the context of HD, including its associated behavioural, cognitive and affective dimensions.
U2 - 10.1016/j.cortex.2019.06.012
DO - 10.1016/j.cortex.2019.06.012
M3 - Journal article
VL - 120
SP - 353
EP - 374
JO - Cortex
JF - Cortex
SN - 0010-9452
ER -