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Variability of β-amyloid protein deposited lesions in Down's syndrome brains

Research output: Contribution to Journal/MagazineJournal articlepeer-review

  • S Ikeda
  • T Tokuda
  • N Yanagisawa
  • F Kametani
  • T Ohshima
  • D Allsop
<mark>Journal publication date</mark>1994
<mark>Journal</mark>The Tohoku Journal of Experimental Medicine
Issue number3
Number of pages10
Pages (from-to)189-198
Publication StatusPublished
<mark>Original language</mark>English


An immunohistochemical study was carried out on the brains of 7 adult Down's syndrome cases (ages 31 to 62) using antibodies to beta-protein, beta-amyloid protein precursor and tau-protein. Variable forms of beta-protein deposited lesions (including senile plaques and cerebrovascular amyloidosis) were observed in extensive areas of the neocortex of all cases and coexistence of both beta-protein amyloid fibrils and beta-amyloid protein precursors was also seen in some of these lesions. Moreover, 3 cases at an advanced stage showed a few plaque-like lesions with beta-protein immunoreactivity in the white matter. The following temporal morphological change is suggested for the pathogenesis of Alzheimer's disease: senile plaque undergo sequential structural changes and beta-protein amyloid deposits in the form of "early plaque" precede the development of tau-immunoreactive neurofibrillary degeneration.