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Variability of β-amyloid protein deposited lesions in Down's syndrome brains

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Variability of β-amyloid protein deposited lesions in Down's syndrome brains. / Ikeda, S; Tokuda, T; Yanagisawa, N; Kametani, F; Ohshima, T; Allsop, D.

In: The Tohoku Journal of Experimental Medicine, Vol. 174, No. 3, 1994, p. 189-198.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Ikeda, S, Tokuda, T, Yanagisawa, N, Kametani, F, Ohshima, T & Allsop, D 1994, 'Variability of β-amyloid protein deposited lesions in Down's syndrome brains', The Tohoku Journal of Experimental Medicine, vol. 174, no. 3, pp. 189-198. <http://www.journalarchive.jst.go.jp/english/jnlabstract_en.php?cdjournal=tjem1920&cdvol=174&noissue=3&startpage=189>

APA

Vancouver

Ikeda S, Tokuda T, Yanagisawa N, Kametani F, Ohshima T, Allsop D. Variability of β-amyloid protein deposited lesions in Down's syndrome brains. The Tohoku Journal of Experimental Medicine. 1994;174(3):189-198.

Author

Ikeda, S ; Tokuda, T ; Yanagisawa, N ; Kametani, F ; Ohshima, T ; Allsop, D. / Variability of β-amyloid protein deposited lesions in Down's syndrome brains. In: The Tohoku Journal of Experimental Medicine. 1994 ; Vol. 174, No. 3. pp. 189-198.

Bibtex

@article{3cd7c7d51efe4bb8acdb255e7ca846b2,
title = "Variability of β-amyloid protein deposited lesions in Down's syndrome brains",
abstract = "An immunohistochemical study was carried out on the brains of 7 adult Down's syndrome cases (ages 31 to 62) using antibodies to beta-protein, beta-amyloid protein precursor and tau-protein. Variable forms of beta-protein deposited lesions (including senile plaques and cerebrovascular amyloidosis) were observed in extensive areas of the neocortex of all cases and coexistence of both beta-protein amyloid fibrils and beta-amyloid protein precursors was also seen in some of these lesions. Moreover, 3 cases at an advanced stage showed a few plaque-like lesions with beta-protein immunoreactivity in the white matter. The following temporal morphological change is suggested for the pathogenesis of Alzheimer's disease: senile plaque undergo sequential structural changes and beta-protein amyloid deposits in the form of {"}early plaque{"} precede the development of tau-immunoreactive neurofibrillary degeneration.",
keywords = "Adult, Alzheimer Disease, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, Brain, Brain Chemistry, Cerebral Amyloid Angiopathy, Down Syndrome, Female, Humans, Immunoenzyme Techniques, Male, Middle Aged, Nerve Degeneration, Nerve Tissue Proteins, Neurites, Neurofibrillary Tangles, Peptide Fragments, RNA Splicing, tau Proteins",
author = "S Ikeda and T Tokuda and N Yanagisawa and F Kametani and T Ohshima and D Allsop",
year = "1994",
language = "English",
volume = "174",
pages = "189--198",
journal = "The Tohoku Journal of Experimental Medicine",
issn = "0040-8727",
publisher = "Tohoku University Medical Press",
number = "3",

}

RIS

TY - JOUR

T1 - Variability of β-amyloid protein deposited lesions in Down's syndrome brains

AU - Ikeda, S

AU - Tokuda, T

AU - Yanagisawa, N

AU - Kametani, F

AU - Ohshima, T

AU - Allsop, D

PY - 1994

Y1 - 1994

N2 - An immunohistochemical study was carried out on the brains of 7 adult Down's syndrome cases (ages 31 to 62) using antibodies to beta-protein, beta-amyloid protein precursor and tau-protein. Variable forms of beta-protein deposited lesions (including senile plaques and cerebrovascular amyloidosis) were observed in extensive areas of the neocortex of all cases and coexistence of both beta-protein amyloid fibrils and beta-amyloid protein precursors was also seen in some of these lesions. Moreover, 3 cases at an advanced stage showed a few plaque-like lesions with beta-protein immunoreactivity in the white matter. The following temporal morphological change is suggested for the pathogenesis of Alzheimer's disease: senile plaque undergo sequential structural changes and beta-protein amyloid deposits in the form of "early plaque" precede the development of tau-immunoreactive neurofibrillary degeneration.

AB - An immunohistochemical study was carried out on the brains of 7 adult Down's syndrome cases (ages 31 to 62) using antibodies to beta-protein, beta-amyloid protein precursor and tau-protein. Variable forms of beta-protein deposited lesions (including senile plaques and cerebrovascular amyloidosis) were observed in extensive areas of the neocortex of all cases and coexistence of both beta-protein amyloid fibrils and beta-amyloid protein precursors was also seen in some of these lesions. Moreover, 3 cases at an advanced stage showed a few plaque-like lesions with beta-protein immunoreactivity in the white matter. The following temporal morphological change is suggested for the pathogenesis of Alzheimer's disease: senile plaque undergo sequential structural changes and beta-protein amyloid deposits in the form of "early plaque" precede the development of tau-immunoreactive neurofibrillary degeneration.

KW - Adult

KW - Alzheimer Disease

KW - Amyloid beta-Peptides

KW - Amyloid beta-Protein Precursor

KW - Brain

KW - Brain Chemistry

KW - Cerebral Amyloid Angiopathy

KW - Down Syndrome

KW - Female

KW - Humans

KW - Immunoenzyme Techniques

KW - Male

KW - Middle Aged

KW - Nerve Degeneration

KW - Nerve Tissue Proteins

KW - Neurites

KW - Neurofibrillary Tangles

KW - Peptide Fragments

KW - RNA Splicing

KW - tau Proteins

M3 - Journal article

C2 - 7761984

VL - 174

SP - 189

EP - 198

JO - The Tohoku Journal of Experimental Medicine

JF - The Tohoku Journal of Experimental Medicine

SN - 0040-8727

IS - 3

ER -