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    Rights statement: This is the author’s version of a work that was accepted for publication in Virology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Virology, 492, 2016 DOI: 10.1016/j.virol.2016.02.013

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Viral forensic genomics reveals the relatedness of classic herpes simplex virus strains KOS, KOS63, and KOS79

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Viral forensic genomics reveals the relatedness of classic herpes simplex virus strains KOS, KOS63, and KOS79. / Bowen, Christopher D.; Renner, Daniel W.; Shreve, Jacob T. et al.
In: Virology, Vol. 492, 05.2016, p. 179-186.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Bowen, CD, Renner, DW, Shreve, JT, Tafuri, Y, Payne, KM, Dix, RD, Kinchington, PR, Gatherer, D & Szpara, ML 2016, 'Viral forensic genomics reveals the relatedness of classic herpes simplex virus strains KOS, KOS63, and KOS79', Virology, vol. 492, pp. 179-186. https://doi.org/10.1016/j.virol.2016.02.013

APA

Bowen, C. D., Renner, D. W., Shreve, J. T., Tafuri, Y., Payne, K. M., Dix, R. D., Kinchington, P. R., Gatherer, D., & Szpara, M. L. (2016). Viral forensic genomics reveals the relatedness of classic herpes simplex virus strains KOS, KOS63, and KOS79. Virology, 492, 179-186. https://doi.org/10.1016/j.virol.2016.02.013

Vancouver

Bowen CD, Renner DW, Shreve JT, Tafuri Y, Payne KM, Dix RD et al. Viral forensic genomics reveals the relatedness of classic herpes simplex virus strains KOS, KOS63, and KOS79. Virology. 2016 May;492:179-186. Epub 2016 Mar 4. doi: 10.1016/j.virol.2016.02.013

Author

Bowen, Christopher D. ; Renner, Daniel W. ; Shreve, Jacob T. et al. / Viral forensic genomics reveals the relatedness of classic herpes simplex virus strains KOS, KOS63, and KOS79. In: Virology. 2016 ; Vol. 492. pp. 179-186.

Bibtex

@article{0d1538e4689e4f60ac285e0e1771a950,
title = "Viral forensic genomics reveals the relatedness of classic herpes simplex virus strains KOS, KOS63, and KOS79",
abstract = "Herpes simplex virus 1 (HSV-1) is a widespread global pathogen, of which the strain KOS is one of the most extensively studied. Previous sequence studies revealed that KOS does not cluster with other strains of North American geographic origin, but instead clustered with Asian strains. We sequenced a historical isolate of the original KOS strain, called KOS63, along with a separately isolated strain attributed to the same source individual, termed KOS79. Genomic analyses revealed that KOS63 closely resembled other recently sequenced isolates of KOS and was of Asian origin, but that KOS79 was a genetically unrelated strain that clustered in genetic distance analyses with HSV-1 strains of North American/European origin. These data suggest that the human source of KOS63 and KOS79 could have been infected with two genetically unrelated strains of disparate geographic origins. A PCR RFLP test was developed for rapid identification of these strains.",
author = "Bowen, {Christopher D.} and Renner, {Daniel W.} and Shreve, {Jacob T.} and Yolanda Tafuri and Payne, {Kimberly M.} and Dix, {Richard D.} and Kinchington, {Paul R.} and Derek Gatherer and Szpara, {Moriah L.}",
note = "This is the author{\textquoteright}s version of a work that was accepted for publication in Virology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Virology, 492, 2016 DOI: 10.1016/j.virol.2016.02.013",
year = "2016",
month = may,
doi = "10.1016/j.virol.2016.02.013",
language = "English",
volume = "492",
pages = "179--186",
journal = "Virology",
issn = "0042-6822",
publisher = "Academic Press Inc.",

}

RIS

TY - JOUR

T1 - Viral forensic genomics reveals the relatedness of classic herpes simplex virus strains KOS, KOS63, and KOS79

AU - Bowen, Christopher D.

AU - Renner, Daniel W.

AU - Shreve, Jacob T.

AU - Tafuri, Yolanda

AU - Payne, Kimberly M.

AU - Dix, Richard D.

AU - Kinchington, Paul R.

AU - Gatherer, Derek

AU - Szpara, Moriah L.

N1 - This is the author’s version of a work that was accepted for publication in Virology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Virology, 492, 2016 DOI: 10.1016/j.virol.2016.02.013

PY - 2016/5

Y1 - 2016/5

N2 - Herpes simplex virus 1 (HSV-1) is a widespread global pathogen, of which the strain KOS is one of the most extensively studied. Previous sequence studies revealed that KOS does not cluster with other strains of North American geographic origin, but instead clustered with Asian strains. We sequenced a historical isolate of the original KOS strain, called KOS63, along with a separately isolated strain attributed to the same source individual, termed KOS79. Genomic analyses revealed that KOS63 closely resembled other recently sequenced isolates of KOS and was of Asian origin, but that KOS79 was a genetically unrelated strain that clustered in genetic distance analyses with HSV-1 strains of North American/European origin. These data suggest that the human source of KOS63 and KOS79 could have been infected with two genetically unrelated strains of disparate geographic origins. A PCR RFLP test was developed for rapid identification of these strains.

AB - Herpes simplex virus 1 (HSV-1) is a widespread global pathogen, of which the strain KOS is one of the most extensively studied. Previous sequence studies revealed that KOS does not cluster with other strains of North American geographic origin, but instead clustered with Asian strains. We sequenced a historical isolate of the original KOS strain, called KOS63, along with a separately isolated strain attributed to the same source individual, termed KOS79. Genomic analyses revealed that KOS63 closely resembled other recently sequenced isolates of KOS and was of Asian origin, but that KOS79 was a genetically unrelated strain that clustered in genetic distance analyses with HSV-1 strains of North American/European origin. These data suggest that the human source of KOS63 and KOS79 could have been infected with two genetically unrelated strains of disparate geographic origins. A PCR RFLP test was developed for rapid identification of these strains.

U2 - 10.1016/j.virol.2016.02.013

DO - 10.1016/j.virol.2016.02.013

M3 - Journal article

C2 - 26950505

VL - 492

SP - 179

EP - 186

JO - Virology

JF - Virology

SN - 0042-6822

ER -