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Wavelet analysis of blood flow dynamics: effect on the individual oscillatory components of iontophoresis with pharmacologically neutral electrolytes

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Wavelet analysis of blood flow dynamics : effect on the individual oscillatory components of iontophoresis with pharmacologically neutral electrolytes. / Veber, Mitja; Bandrivskyy, Andriy; Clarkson, Peter B. M.; McClintock, Peter V. E.; Stefanovska, Aneta.

In: Physics in Medicine and Biology, Vol. 49, No. 8, 21.04.2004, p. N111-117.

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Veber, Mitja ; Bandrivskyy, Andriy ; Clarkson, Peter B. M. ; McClintock, Peter V. E. ; Stefanovska, Aneta. / Wavelet analysis of blood flow dynamics : effect on the individual oscillatory components of iontophoresis with pharmacologically neutral electrolytes. In: Physics in Medicine and Biology. 2004 ; Vol. 49, No. 8. pp. N111-117.

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@article{2517d7c0035d48e48ad6ad650c540016,
title = "Wavelet analysis of blood flow dynamics: effect on the individual oscillatory components of iontophoresis with pharmacologically neutral electrolytes",
abstract = "Iontophoresis currents are used in the transcutaneous delivery of vasoactive substances for noninvasive assessment of skin vascular properties. The blood flow rate can be recorded by laser Doppler flowmetry (LDF), its average value and the amplitudes of its oscillatory components being used to evaluate the effect of the drugs. Because non-drug-specific, current-induced, vasodilation could confound the interpretation of the response, we have investigated the effect of currents of both polarities on the spectral components of the LDF signal in the absence of vasoactive substances. It was recorded for healthy volunteers with both high conductance (5 mol/l NaCl) and low conductance (deionized water) electrolytes. The oscillatory components were analysed by wavelet transform within 0.0095–1.6 Hz, divided into five sub-intervals. Only cathodal iontophoresis with deionized water increased the oscillatory energy and amplitude. It did so at all frequencies, but none of the sub-intervals associated with vasodilation (0.0095–0.145 Hz) was selectively affected compared to the others.",
author = "Mitja Veber and Andriy Bandrivskyy and Clarkson, {Peter B. M.} and McClintock, {Peter V. E.} and Aneta Stefanovska",
year = "2004",
month = apr,
day = "21",
doi = "10.1088/0031-9155/49/8/N03",
language = "English",
volume = "49",
pages = "N111--117",
journal = "Physics in Medicine and Biology",
issn = "0031-9155",
publisher = "IOP Publishing Ltd.",
number = "8",

}

RIS

TY - JOUR

T1 - Wavelet analysis of blood flow dynamics

T2 - effect on the individual oscillatory components of iontophoresis with pharmacologically neutral electrolytes

AU - Veber, Mitja

AU - Bandrivskyy, Andriy

AU - Clarkson, Peter B. M.

AU - McClintock, Peter V. E.

AU - Stefanovska, Aneta

PY - 2004/4/21

Y1 - 2004/4/21

N2 - Iontophoresis currents are used in the transcutaneous delivery of vasoactive substances for noninvasive assessment of skin vascular properties. The blood flow rate can be recorded by laser Doppler flowmetry (LDF), its average value and the amplitudes of its oscillatory components being used to evaluate the effect of the drugs. Because non-drug-specific, current-induced, vasodilation could confound the interpretation of the response, we have investigated the effect of currents of both polarities on the spectral components of the LDF signal in the absence of vasoactive substances. It was recorded for healthy volunteers with both high conductance (5 mol/l NaCl) and low conductance (deionized water) electrolytes. The oscillatory components were analysed by wavelet transform within 0.0095–1.6 Hz, divided into five sub-intervals. Only cathodal iontophoresis with deionized water increased the oscillatory energy and amplitude. It did so at all frequencies, but none of the sub-intervals associated with vasodilation (0.0095–0.145 Hz) was selectively affected compared to the others.

AB - Iontophoresis currents are used in the transcutaneous delivery of vasoactive substances for noninvasive assessment of skin vascular properties. The blood flow rate can be recorded by laser Doppler flowmetry (LDF), its average value and the amplitudes of its oscillatory components being used to evaluate the effect of the drugs. Because non-drug-specific, current-induced, vasodilation could confound the interpretation of the response, we have investigated the effect of currents of both polarities on the spectral components of the LDF signal in the absence of vasoactive substances. It was recorded for healthy volunteers with both high conductance (5 mol/l NaCl) and low conductance (deionized water) electrolytes. The oscillatory components were analysed by wavelet transform within 0.0095–1.6 Hz, divided into five sub-intervals. Only cathodal iontophoresis with deionized water increased the oscillatory energy and amplitude. It did so at all frequencies, but none of the sub-intervals associated with vasodilation (0.0095–0.145 Hz) was selectively affected compared to the others.

U2 - 10.1088/0031-9155/49/8/N03

DO - 10.1088/0031-9155/49/8/N03

M3 - Journal article

VL - 49

SP - N111-117

JO - Physics in Medicine and Biology

JF - Physics in Medicine and Biology

SN - 0031-9155

IS - 8

ER -