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When indoles meet allene and its derivatives

Research output: Contribution to Journal/MagazineJournal articlepeer-review

<mark>Journal publication date</mark>22/10/2020
<mark>Journal</mark>European Journal of Organic Chemistry
Issue number46
Number of pages17
Pages (from-to)7197-7213
Publication StatusPublished
<mark>Original language</mark>English


The allene functional group and the indole ring have emerged as recurring building blocks in organic chemistry due to their diverse reactivity and straightforward preparation. In addition, the biological properties and natural occurrence of indole give a remarkable added-value to newly-prepared indole-based structures. In the last decade, the combination of allenes and indoles as co-reactants has revealed a fruitful reactivity allowing the synthesis of complex structures and the investigation of new mechanistic pathways, such as the challenging asymmetric nucleophilic addition using optically pure allenes as chirality transfer agents, the double nucleophilic addition through metal carbene intermediates, or novel hybrid catalysis in a bimetallic system. Herein we report a critical review into the wide and fascinating ways allenes and indoles can interact, and the structural diversity that can be therefore achieved.

Bibliographic note

Invited contribution for the Special issue called "your JOCTalents"