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Whole genome linkage scan of recurrent depressive disorder from the depression network study

Research output: Contribution to Journal/MagazineJournal articlepeer-review

  • Peter McGuffin
  • Jo Knight
  • Gerome Breen
  • Shyama Brewster
  • Peter R. Boyd
  • Nick Craddock
  • Mike Gill
  • Ania Korszun
  • Wolfgang Maier
  • Lefkos Middleton
  • Ole Mors
  • Michael J. Owen
  • Julia Perry
  • Martin Preisig
  • Theodore Reich
  • John Rice
  • Marcella Rietschel
  • Lisa Jones
  • Pak Sham
  • Anne E. Farmer
<mark>Journal publication date</mark>15/11/2005
<mark>Journal</mark>Human Molecular Genetics
Issue number22
Number of pages9
Pages (from-to)3337-3345
Publication StatusPublished
Early online date3/10/05
<mark>Original language</mark>English


Genome-wide linkage analysis was carried out in a sample of 497 sib pairs concordant for recurrent major depressive disorder (MDD). There was suggestive evidence for linkage on chromosome 1p36 where the LOD score for female-female pairs exceeded 3 (but reduced to 2.73 when corrected for multiple testing). The region includes a gene, MTHFR, that in previous studies has been associated with depressive symptoms. Two other regions, on chromosomes 12q23.3-q24.11 and 13q31.1-q31.3, showed evidence for linkage with a nominal P < 0.01. The 12q peak overlaps with a region previously implicated by linkage studies of unipolar and bipolar disorders and contains a gene, DAO, that has been associated with both bipolar disorder and schizophrenia. The 13q peak lies within a region previously linked strongly to panic disorder. A fourth modest peak with an LOD of greater than 1 on chromosome 15q lies within a region that showed genome-wide significant evidence of a recurrent depression locus in a previous sib-pair study. Both the 12q and the 15q findings remained significant at genome-wide level when the data from the present study and the previous reports were combined.