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Whole genome linkage scan of recurrent depressive disorder from the depression network study

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Whole genome linkage scan of recurrent depressive disorder from the depression network study. / McGuffin, Peter; Knight, Jo; Breen, Gerome et al.
In: Human Molecular Genetics, Vol. 14, No. 22, 15.11.2005, p. 3337-3345.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

McGuffin, P, Knight, J, Breen, G, Brewster, S, Boyd, PR, Craddock, N, Gill, M, Korszun, A, Maier, W, Middleton, L, Mors, O, Owen, MJ, Perry, J, Preisig, M, Reich, T, Rice, J, Rietschel, M, Jones, L, Sham, P & Farmer, AE 2005, 'Whole genome linkage scan of recurrent depressive disorder from the depression network study', Human Molecular Genetics, vol. 14, no. 22, pp. 3337-3345. https://doi.org/10.1093/hmg/ddi363

APA

McGuffin, P., Knight, J., Breen, G., Brewster, S., Boyd, P. R., Craddock, N., Gill, M., Korszun, A., Maier, W., Middleton, L., Mors, O., Owen, M. J., Perry, J., Preisig, M., Reich, T., Rice, J., Rietschel, M., Jones, L., Sham, P., & Farmer, A. E. (2005). Whole genome linkage scan of recurrent depressive disorder from the depression network study. Human Molecular Genetics, 14(22), 3337-3345. https://doi.org/10.1093/hmg/ddi363

Vancouver

McGuffin P, Knight J, Breen G, Brewster S, Boyd PR, Craddock N et al. Whole genome linkage scan of recurrent depressive disorder from the depression network study. Human Molecular Genetics. 2005 Nov 15;14(22):3337-3345. Epub 2005 Oct 3. doi: 10.1093/hmg/ddi363

Author

McGuffin, Peter ; Knight, Jo ; Breen, Gerome et al. / Whole genome linkage scan of recurrent depressive disorder from the depression network study. In: Human Molecular Genetics. 2005 ; Vol. 14, No. 22. pp. 3337-3345.

Bibtex

@article{a0cf0f05903d452b85da4a05a03799b3,
title = "Whole genome linkage scan of recurrent depressive disorder from the depression network study",
abstract = "Genome-wide linkage analysis was carried out in a sample of 497 sib pairs concordant for recurrent major depressive disorder (MDD). There was suggestive evidence for linkage on chromosome 1p36 where the LOD score for female-female pairs exceeded 3 (but reduced to 2.73 when corrected for multiple testing). The region includes a gene, MTHFR, that in previous studies has been associated with depressive symptoms. Two other regions, on chromosomes 12q23.3-q24.11 and 13q31.1-q31.3, showed evidence for linkage with a nominal P < 0.01. The 12q peak overlaps with a region previously implicated by linkage studies of unipolar and bipolar disorders and contains a gene, DAO, that has been associated with both bipolar disorder and schizophrenia. The 13q peak lies within a region previously linked strongly to panic disorder. A fourth modest peak with an LOD of greater than 1 on chromosome 15q lies within a region that showed genome-wide significant evidence of a recurrent depression locus in a previous sib-pair study. Both the 12q and the 15q findings remained significant at genome-wide level when the data from the present study and the previous reports were combined.",
keywords = "Adolescent, Adult, Alleles, Chromosome Mapping, Depressive Disorder, Female, Gene Frequency, Genetic Linkage, Genome, Human, Humans, Lod Score, Male, Recurrence, Twin Studies as Topic",
author = "Peter McGuffin and Jo Knight and Gerome Breen and Shyama Brewster and Boyd, {Peter R.} and Nick Craddock and Mike Gill and Ania Korszun and Wolfgang Maier and Lefkos Middleton and Ole Mors and Owen, {Michael J.} and Julia Perry and Martin Preisig and Theodore Reich and John Rice and Marcella Rietschel and Lisa Jones and Pak Sham and Farmer, {Anne E.}",
year = "2005",
month = nov,
day = "15",
doi = "10.1093/hmg/ddi363",
language = "English",
volume = "14",
pages = "3337--3345",
journal = "Human Molecular Genetics",
issn = "0964-6906",
publisher = "Oxford University Press",
number = "22",

}

RIS

TY - JOUR

T1 - Whole genome linkage scan of recurrent depressive disorder from the depression network study

AU - McGuffin, Peter

AU - Knight, Jo

AU - Breen, Gerome

AU - Brewster, Shyama

AU - Boyd, Peter R.

AU - Craddock, Nick

AU - Gill, Mike

AU - Korszun, Ania

AU - Maier, Wolfgang

AU - Middleton, Lefkos

AU - Mors, Ole

AU - Owen, Michael J.

AU - Perry, Julia

AU - Preisig, Martin

AU - Reich, Theodore

AU - Rice, John

AU - Rietschel, Marcella

AU - Jones, Lisa

AU - Sham, Pak

AU - Farmer, Anne E.

PY - 2005/11/15

Y1 - 2005/11/15

N2 - Genome-wide linkage analysis was carried out in a sample of 497 sib pairs concordant for recurrent major depressive disorder (MDD). There was suggestive evidence for linkage on chromosome 1p36 where the LOD score for female-female pairs exceeded 3 (but reduced to 2.73 when corrected for multiple testing). The region includes a gene, MTHFR, that in previous studies has been associated with depressive symptoms. Two other regions, on chromosomes 12q23.3-q24.11 and 13q31.1-q31.3, showed evidence for linkage with a nominal P < 0.01. The 12q peak overlaps with a region previously implicated by linkage studies of unipolar and bipolar disorders and contains a gene, DAO, that has been associated with both bipolar disorder and schizophrenia. The 13q peak lies within a region previously linked strongly to panic disorder. A fourth modest peak with an LOD of greater than 1 on chromosome 15q lies within a region that showed genome-wide significant evidence of a recurrent depression locus in a previous sib-pair study. Both the 12q and the 15q findings remained significant at genome-wide level when the data from the present study and the previous reports were combined.

AB - Genome-wide linkage analysis was carried out in a sample of 497 sib pairs concordant for recurrent major depressive disorder (MDD). There was suggestive evidence for linkage on chromosome 1p36 where the LOD score for female-female pairs exceeded 3 (but reduced to 2.73 when corrected for multiple testing). The region includes a gene, MTHFR, that in previous studies has been associated with depressive symptoms. Two other regions, on chromosomes 12q23.3-q24.11 and 13q31.1-q31.3, showed evidence for linkage with a nominal P < 0.01. The 12q peak overlaps with a region previously implicated by linkage studies of unipolar and bipolar disorders and contains a gene, DAO, that has been associated with both bipolar disorder and schizophrenia. The 13q peak lies within a region previously linked strongly to panic disorder. A fourth modest peak with an LOD of greater than 1 on chromosome 15q lies within a region that showed genome-wide significant evidence of a recurrent depression locus in a previous sib-pair study. Both the 12q and the 15q findings remained significant at genome-wide level when the data from the present study and the previous reports were combined.

KW - Adolescent

KW - Adult

KW - Alleles

KW - Chromosome Mapping

KW - Depressive Disorder

KW - Female

KW - Gene Frequency

KW - Genetic Linkage

KW - Genome, Human

KW - Humans

KW - Lod Score

KW - Male

KW - Recurrence

KW - Twin Studies as Topic

U2 - 10.1093/hmg/ddi363

DO - 10.1093/hmg/ddi363

M3 - Journal article

C2 - 16203746

VL - 14

SP - 3337

EP - 3345

JO - Human Molecular Genetics

JF - Human Molecular Genetics

SN - 0964-6906

IS - 22

ER -