Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - X-ray phase contrast imaging of biological specimens with femtosecond pulses of betatron radiation from a compact laser plasma wakefield accelerator
AU - Kneip, S.
AU - McGuffey, C.
AU - Dollar, F.
AU - Bloom, M. S.
AU - Chvykov, V.
AU - Kalintchenko, G.
AU - Krushelnick, K.
AU - Maksimchuk, A.
AU - Mangles, S. P. D.
AU - Matsuoka, T.
AU - Najmudin, Z.
AU - Palmer, C. A. J.
AU - Schreiber, J.
AU - Schumaker, W.
AU - Thomas, A. G. R.
AU - Yanovsky, V.
PY - 2011/8/29
Y1 - 2011/8/29
N2 - We show that x-rays from a recently demonstrated table top source of bright, ultrafast, coherent synchrotron radiation [Kneip et al., Nat. Phys. 6, 980 (2010)] can be applied to phase contrast imaging of biological specimens. Our scheme is based on focusing a high power short pulse laser in a tenuous gas jet, setting up a plasma wakefield accelerator that accelerates and wiggles electrons analogously to a conventional synchrotron, but on the centimeter rather than tens of meter scale. We use the scheme to record absorption and phase contrast images of a tetra fish, damselfly and yellow jacket, in particular highlighting the contrast enhancement achievable with the simple propagation technique of phase contrast imaging. Coherence and ultrafast pulse duration will allow for the study of various aspects of biomechanics. (C) 2011 American Institute of Physics. [doi:10.1063/1.3627216]
AB - We show that x-rays from a recently demonstrated table top source of bright, ultrafast, coherent synchrotron radiation [Kneip et al., Nat. Phys. 6, 980 (2010)] can be applied to phase contrast imaging of biological specimens. Our scheme is based on focusing a high power short pulse laser in a tenuous gas jet, setting up a plasma wakefield accelerator that accelerates and wiggles electrons analogously to a conventional synchrotron, but on the centimeter rather than tens of meter scale. We use the scheme to record absorption and phase contrast images of a tetra fish, damselfly and yellow jacket, in particular highlighting the contrast enhancement achievable with the simple propagation technique of phase contrast imaging. Coherence and ultrafast pulse duration will allow for the study of various aspects of biomechanics. (C) 2011 American Institute of Physics. [doi:10.1063/1.3627216]
KW - COMPUTED-TOMOGRAPHY
KW - ELECTRON-BEAMS
U2 - 10.1063/1.3627216
DO - 10.1063/1.3627216
M3 - Journal article
VL - 99
JO - Applied Physics Letters
JF - Applied Physics Letters
SN - 0003-6951
IS - 9
M1 - 093701
ER -