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Professor Christian Holscher

Formerly at Lancaster University

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  1. Published

    A novel GLP-1/GIP dual receptor agonist protects from 6-OHDA lesion in a rat model of Parkinson's disease

    Jalewa, J., Sharma, M. K., Gengler, S. & Hölscher, C., 1/05/2017, In: Neuropharmacology. 117, p. 238-248 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  2. Published

    Neuroprotective effects of glucose-dependent insulinotropic polypeptide in Alzheimer's disease

    Ji, C., Xue, G.-F., Li, G., Li, D. & Holscher, C., 01/2016, In: Reviews in the Neurosciences. 27, 1, p. 61-70 10 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  3. Published

    A novel dual GLP-1 and GIP receptor agonist is neuroprotective in the MPTP mouse model of Parkinson′s disease by increasing expression of BNDF

    Ji, C., Xue, G.-F., Lijun, C., Feng, P., Li, D., Li, L., Li, G. & Holscher, C., 1/03/2016, In: Brain Research. 1634, p. 1-11 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  4. Published

    GLP-1/GIP/Gcg三受体激动剂改善3xTg-AD小鼠认知行为和病理特征研究

    Jiao, J.-J., Hölscher, C., Li, T., Dong, X.-F., Qu, X.-S., Cao, Y., Wu, M.-N., Wang, Z.-J. & Qi, J.-S., 25/04/2017, In: Acta Physiologica Sinica. 69, 2, p. 135-145 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  5. Published

    Integrating microRNA and messenger RNA expression profiles in a rat model of deep vein thrombosis

    Jin, Q.-Q., Sun, J.-H., Du, Q.-X., Lu, X.-J., Zhu, X.-Y., Fan, H.-L., Holscher, C. & Wang, Y.-Y., 10/2017, In: International Journal of Molecular Medicine. 40, 4, p. 1019-1028 10 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  6. Published

    Restoration of cerebral and systemic microvascular architecture in APP/PS1 transgenic mice following treatment with Liraglutide™

    Kelly, P., McClean, P. L., Ackermann, M., Konerding, M. A., Holscher, C. & Mitchell, C. A., 02/2015, In: Microcirculation. 22, 2, p. 133-145 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  7. Published

    Comparison of the independent and combined effects of sub-chronic therapy with metformin and a stable GLP-1 receptor agonist on cognitive function, hippocampal synaptic plasticity and metabolic control in high-fat fed mice

    Lennox, R., Porter, D. W., Flatt, P. R., Holscher, C., Irwin, N. & Gault, V. A., 11/2014, In: Neuropharmacology. 86, p. 22-30 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  8. Published

    (Val⁸) glucagon-like peptide-1 prevents tau hyperphosphorylation, impairment of spatial learning and ultra-structural cellular damage induced by streptozotocin in rat brains

    Li, L., Zhang, Z.-F., Hölscher, C., Gao, C., Jiang, Y.-H. & Liu, Y.-Z., 15/01/2012, In: European Journal of Pharmacology. 674, 2-3, p. 280-286 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  9. Published

    Hepcidin treatment modulates the expression of divalent metal transporter-1, ceruloplasmin, and ferroportin-1 in the rat cerebral cortex and hippocampus

    Li, L., Hölscher, C., Chen, B.-B., Zhang, Z.-F. & Liu, Y.-Z., 12/2011, In: Biological Trace Element Research. 143, 3, p. 1581-1593 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  10. Published

    Neuroprotective effects of a GIP analogue in the MPTP Parkinson's disease mouse model

    Li, Y., Liu, W., Li, L. & Holscher, C., 02/2016, In: Neuropharmacology. 101, p. 255-263 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  11. Published

    Neuroprotective role of (Val8)GLP-1-Glu-PAL in an in vitro model of Parkinson’s disease

    Li, L., Liu, K., Holscher, C., Li, G. & Liu, Y.-Z., 2016, In: Neural Regeneration Research. 11, 2, p. 326-331 6 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  12. Published

    Therapeutic potential of genipin in central neurodegenerative diseases

    Li, Y., Li, L. & Holscher, C., 10/2016, In: CNS Drugs. 30, 10, p. 889-897 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  13. Published

    Incretin-based therapy for type 2 diabetes mellitus is promising for treating neurodegenerative diseases

    Li, Y., Li, L. & Holscher, C., 10/2016, In: Reviews in the Neurosciences. 27, 7, p. 689-711 23 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  14. Published

    D-Ala2-GIP-glu-PAL is neuroprotective in a chronic Parkinson's disease mouse model and increases BNDF expression while reducing neuroinflammation and lipid peroxidation

    Li, Y., Liu, W., Li, L. & Holscher, C., 15/02/2017, In: European Journal of Pharmacology. 797, p. 162-172 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  15. Published

    Therapeutic Potential of Baicalein in Alzheimer's Disease and Parkinson's Disease

    Li, Y., Zhao, J. & Holscher, C., 08/2017, In: CNS Drugs. 31, 8, p. 639-652 14 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  16. Published

    A novel dual GLP-1 and GIP incretin receptor agonist is neuroprotective in a mouse model of Parkinson’s disease by reducing chronic inflammation in the brain

    Lijun, C., Li, D., Feng, P., Li, L., Xue, G., Li, G. & Holscher, C., 13/04/2016, In: NeuroReport. 27, 6, p. 384-391 8 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  17. Published

    Neuroprotective effects of an oxyntomodulin analogue in the MPTP mouse model of Parkinson's disease

    Liu, W., Li, Y., Jalewa, J., Saunders-Wood, T., Li, L. & Hölscher, C., 2015, In: European Journal of Pharmacology. 765, p. 284-290 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  18. Published

    Neuroprotective effects of lixisenatide and liraglutide in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

    Liu, W., Jalewa, J., Sharma, M., Li, G., Li, L. & Holscher, C., 10/09/2015, In: Neuroscience. 303, p. 42-50 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  19. Published

    Neuroprotective effects of geniposide on Alzheimer's disease pathology

    Liu, W., Li, G., Holscher, C. & Li, L., 08/2015, In: Reviews in the Neurosciences. 26, 4, p. 371-383 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  20. Published

    The diabetes drug liraglutide ameliorates aberrant insulin receptor localisation and signalling in parallel with decreasing both amyloid-β plaque and glial pathology in a mouse model of Alzheimer's disease

    Long-Smith, C. M., Manning, S., McClean, P. L., Coakley, M. F., O'Halloran, D. J., Holscher, C. & O'Neill, C., 03/2013, In: NeuroMolecular Medicine. 15, 1, p. 102-114 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  21. Published

    TNF-α mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's β-Amyloid oligomers in mice and monkeys

    Lourenco, M. V., Clarke, J. R., Frozza, R. L., Bomfim, T. R., Forny-Germano, L., Batista, A. F., Sathler, L. B., Brito-Moreira, J., Amaral, O. B., Silva, C. A., Freitas-Correa, L., Espírito-Santo, S., Campello-Costa, P., Houzel, J.-C., Klein, W. L., Holscher, C., Carvalheira, J. B., Silva, A. M., Velloso, L. A. & Munoz, D. P. & 2 others, Ferreira, S. T. & De Felice, F. G., 3/12/2013, In: Cell Metabolism. 18, 6, p. 831-843 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  22. Published

    Glucagon like peptide-1 receptor agonists as neuroprotective agents for ischemic stroke: a systematic scoping review

    Maskery, M. P., Holscher, C., Jones, S. P., Price, C. I., Strain, W. D., Watkins, C. L., Werring, D. J. & Emsley, H. C. A., 1/01/2021, In: Journal of Cerebral Blood Flow and Metabolism. 41, 1, p. 14-30 17 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  23. Published

    The diabetes drug Liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease

    McClean, P. L., Parthsarathy, V., Faivre, E. & Holscher, C., 27/04/2011, In: Journal of Neuroscience. 31, 17, p. 6587-6594 8 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  24. Published

    Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer ‘s disease

    McClean, P. L. & Holscher, C., 2013, In: Neuropharmacology. 76, Part A, p. 57-67 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  25. Published

    Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain: a link between diabetes and Alzheimer's disease

    McClean, P. L., Gault, V. A., Harriott, P. & Hölscher, C., 25/03/2010, In: European Journal of Pharmacology. 630, 1-3, p. 158-162 5 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  26. Published

    Prophylactic liraglutide treatment prevents amyloid plaque deposition, chronic inflammation and memory impairment in APP/PS1 mice

    McClean, P. L., Jalewa, J. & Holscher, C., 15/10/2015, In: Behavioural Brain Research. 293, p. 96-106 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  27. Published

    Lixisenatide, a drug developed to treat type 2 diabetes, shows neuroprotective effects in a mouse model of Alzheimer's disease

    McClean, P. L. & Holscher, C., 11/2014, In: Neuropharmacology. 86, p. 241-258 18 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  28. Published

    Effects of the glucagon-like polypeptide-1 analogue (Val8)GLP-1 on learning, progenitor cell proliferation and neurogenesis in the C57B/16 mouse brain

    McGovern, S. F. J., Hunter, K. & Hölscher, C., 14/09/2012, In: Brain Research. 1473, p. 204-213 10 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  29. Published

    Wide-ranging alterations in the brain fatty acid complement of subjects with late Alzheimer’s disease as detected by GC-MS

    Nasaruddin, M. L., Holscher, C., Kehoe, P., Graham, S. F. & Green, B., 30/01/2016, In: American Journal of Translational Research. 8, 1, p. 154-165 12 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  30. Published

    Pharmacological inhibition of CSF1R blocks microglial proliferation and prevents the progression of Alzheimer's-like pathology

    Olmos-Alonso, A., Schetters, S. T., Sri, S., Askew, K., Vargas-Caballero, M., Holscher, C., Perry, V. H. & Gomez-Nicola, D., 08/2015, In: Glia. 63, Suppl. 1, p. E346-E347 2 p.

    Research output: Contribution to Journal/Magazine › Meeting abstract › peer-review

  31. Published

    Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer's-like pathology

    Olmos-Alonso, A., Schetters, S. T. T., Sri, S., Askew, K., Mancuso, R., Vargas-Caballero, M., Holscher, C., Perry, V. H. & Gomez-Nicola, D., 1/03/2016, In: Brain. 139, 3, p. 891-907 17 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  32. Published

    Alzheimer's disease–like pathology has transient effects on the brain and blood metabolome

    Pan, X., Nasaruddin, M. B., Elliott, C. T., McGuinness, B., Passmore, A. P., Kehoe, P. G., Holscher, C., McClean, P. L., Graham, S. F. & Green, B. D., 02/2016, In: Neurobiology of Aging. 38, p. 151-163 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  33. Published

    Liraglutide restores chronic ER stress, autophagy impairments and apoptotic signalling in SH-SY5Y cells

    Panagaki, T., Michael, M. & Hölscher, C., 23/11/2017, In: Scientific Reports. 7, 16 p., 16158.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  34. Published

    The Novel DA-CH3 Dual Incretin Restores Endoplasmic Reticulum Stress and Autophagy Impairments to Attenuate Alzheimer-Like Pathology and Cognitive Decrements in the APPSWE/PS1ΔE9 Mouse Model

    Panagaki, T., Gengler, S. & Hölscher, C., 16/10/2018, In: Journal of Alzheimer's Disease. 66, 1, p. 195-218 24 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  35. Published

    Chronic treatment with the GLP1 analogue liraglutide increases cell proliferation and differentiation into neurons in an AD mouse model

    Parthsarathy, V. & Holscher, C., 11/03/2013, In: PLoS ONE. 8, 3, e58784.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  36. Published

    The type 2 diabetes drug liraglutide reduces chronic inflammation induced by irradiation in the mouse brain

    Parthsarathy, V. & Hölscher, C., 30/01/2013, In: European Journal of Pharmacology. 700, 1-3, p. 42-50 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  37. Published

    Liraglutide improves hippocampal synaptic plasticity associated with increased expression of Mash1 in ob/ob mice

    Porter, W. D., Flatt, P. R., Hölscher, C. & Gault, V. A., 05/2013, In: International Journal of Obesity. 37, 5, p. 678-684 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  38. Published

    Prolonged GIP receptor activation improves cognitive function, hippocampal synaptic plasticity and glucose homeostasis in high-fat fed mice

    Porter, D. W., Irwin, N., Flatt, P. R., Hölscher, C. & Gault, V. A., 15/01/2011, In: European Journal of Pharmacology. 650, 2-3, p. 688-693 6 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  39. Published

    Four weeks administration of Liraglutide improves memory and learning as well as glycaemic control in mice with high fat dietary-induced obesity and insulin resistance

    Porter, D. W., Kerr, B. D., Flatt, P. R., Hölscher, C. & Gault, V. A., 10/2010, In: Diabetes, Obesity and Metabolism. 12, 10, p. 891-899 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  40. Published

    Acylated Ghrelin as a Multi-Targeted Therapy for Alzheimer's and Parkinson's Disease.

    Reich, N. & Hölscher, C., 14/12/2020, In: Frontiers in Neuroscience. 14, 35 p., 614828.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  41. Published

    Beyond appetite: Acylated ghrelin as a learning, memory and fear behavior-modulating hormone

    Reich, N. & Hölscher, C., 31/12/2022, In: Neuroscience and Biobehavioral Reviews. 143, 27 p., 104952.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  42. Published

    A novel bioresorbable device as a controlled release system for protecting cells from oxidative stress from Alzheimer’s Disease

    Salles, G. N., Pereira, F. A. D. S., Pacheco-Soares, C., Marciano, F. R., Holscher, C., Webster, T. J. & Lobo, A. O., 11/2017, In: Molecular Neurobiology. 54, 9, p. 6827-6838 12 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  43. Published

    Prolonged Drug-Releasing Fibers Attenuate Alzheimer's Disease-like Pathogenesis

    Salles, G. N., Calió, M. L., Afewerki, S., Pacheco-Soares, C., Porcionatto, M., Hölscher, C. & Lobo, A. O., 31/10/2018, In: ACS Applied Materials and Interfaces. 10, 43, p. 36693-36702 10 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  44. Published

    Neuroprotective and anti-apoptotic effects of Liraglutide on SH-SY5Y cells exposed to Methylglyoxal stress

    Sharma, M., Jalewa, J. & Hölscher, C., 02/2014, In: Journal of Neurochemistry. 128, 3, p. 459-471 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  45. Published

    A novel dual GLP-1/GIP receptor agonist alleviates cognitive decline by re-sensitizing insulin signaling in the Alzheimer icv. STZ rat model

    Shi, L., Zhang, Z. & Hölscher, C., 1/06/2017, In: Behavioural Brain Research. 327, p. 65-74 10 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  46. Published

    Neuroprotective effects of a triple GLP-1/GIP/glucagon receptor agonist in the APP/PS1 transgenic mouse model of Alzheimer's disease

    Tai, J., Liu, W., Li, Y., Li, L. & Hölscher, C., 1/01/2018, In: Brain Research. 1678, p. 64-74 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  47. Published

    Val⁸-GLP-1 remodels synaptic activity and intracellular calcium homeostasis impaired by amyloid β peptide in rats

    Wang, X.-H., Yang, W., Hölscher, C., Wang, Z.-J., Cai, H.-Y., Li, Q.-S. & Qi, J.-S., 04/2013, In: Journal of Neuroscience Research. 91, 4, p. 568-577 10 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  48. Published

    Post-treatment with the GLP-1 analogue liraglutide alleviate chronic inflammation and mitochondrial stress induced by Status epilepticus

    Wang, R.-F., Xue, G.-F., Hölscher, C., Tian, M.-J., Feng, P., Zheng, J.-Y. & Li, D.-F., 05/2018, In: Epilepsy Research. 142, p. 45-52 8 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  49. Published

    DA-JC1 improves learning and memory by antagonizing Aβ31-35-induced circadian rhythm disorder

    Wang, L., Zhang, R., Hou, X., Wang, C., Guo, S., Ning, N., Sun, C., Yuan, Y., Li, L., Hölscher, C. & Wang, X., 11/02/2019, In: Molecular Brain. 12, 1, 14 p., 12.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  50. Published

    Liraglutide Attenuates the Depressive- and Anxiety-like Behaviour in the Corticosterone Induced Depression Model Via Improving Hippocampal Neural Plasticity

    Weina, H., Yuhu, N., Hölscher, C., Birong, L., Feiyu, S. & Le, W., 1/09/2018, In: Brain Research. 1694, p. 55-62 8 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

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