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Research

Professor Thomas Jaki

Formerly at Lancaster University

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  1. Published

    AGILE-ACCORD: A Randomized, Multicentre, Seamless, Adaptive Phase I/II Platform Study to Determine the Optimal Dose, Safety and Efficacy of Multiple Candidate Agents for the Treatment of COVID-19: A structured summary of a study protocol for a randomised platform trial

    UK NIHR Community, 19/06/2020, In: Trials. 21, 1, 3 p., 544.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  2. Published

    A comparison of phase I dose-finding designs in clinical trials with monotonicity assumption violation

    Abbas, R., Rossoni, C., Jaki, T., Paoletti, X. & Mozgunov, P., 1/10/2020, In: Clinical Trials. 17, 5, p. 522-534 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  3. Published

    Study to evaluate the optimal dose of remifentanil required to ensure apnea during magnetic resonance imaging of the heart under general anesthesia

    Arnold, P., Sanaulla, S., Hampson, L. V., Davis, A., Tan, J., Cowen, R., Kaleem, M., Williams, A., Wadsworth, I. & Jaki, T., 31/05/2021, In: Paediatric Anesthesia. 31, 5, p. 548-556 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  4. Published

    Subgroup identification in clinical trials via the predicted individual treatment effect

    Ballarini, N. M., Rosenkranz, G. K., Jaki, T., König, F. & Posch, M., 18/10/2018, In: PLoS ONE. 13, 10, 22 p., e0205971.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  5. Published

    A Critical Review of Graphics for Subgroup Analyses in Clinical Trials

    Ballarini, N. M., Chiu, Y.-D., Koenig, F., Posch, M. & Jaki, T., 1/09/2020, In: Pharmaceutical Statistics. 19, 5, p. 541-560 20 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  6. Published

    Optimizing subgroup selection in two-stage adaptive enrichment and umbrella designs

    Ballarini, N. M., Burnett, T., Jaki, T., Jennison, C., König, F. & Posch, M., 31/05/2021, In: Statistics in Medicine. 40, 12, p. 2939-2956 18 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  7. Published

    Optimal Designs for Non-Compartmental Analysis of Pharmacokinetic Studies

    Barnett, H. Y., Geys, H., Jacobs, T. & Jaki, T. F., 2018, In: Statistics in Biopharmaceutical Research. 10, 4, p. 255-263 9 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  8. Published

    Comparing sampling methods for pharmacokinetic studies using model averaged derived parameters

    Barnett, H. Y., Geys, H., Jacobs, T. & Jaki, T., 30/11/2017, In: Statistics in Medicine. 36, 27, p. 4301-4315 15 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  9. Published

    Methods for Non-Compartmental Pharmacokinetic Analysis With Observations Below the Limit of Quantification

    Barnett, H. Y., Geys, H., Jacobs, T. & Jaki, T., 2/01/2021, In: Statistics in Biopharmaceutical Research. 13, 1, p. 59-70 12 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  10. Published

    A novel statistical test for treatment differences in clinical trials using a response‐adaptive forward‐looking Gittins Index Rule

    Barnett, H. Y., Villar, S. S., Geys, H. & Jaki, T., 31/03/2023, In: Biometrics. 79, 1, p. 86-97 12 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  11. Published

    Dose finding studies for therapies with late‐onset toxicities: A comparison study of designs

    Barnett, H., Boix, O., Kontos, D. & Jaki, T., 30/12/2022, In: Statistics in Medicine. 41, 30, p. 5767-5788 22 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  12. Published

    Backfilling cohorts in phase I dose-escalation studies

    Barnett, H., Boix, O., Kontos, D. & Jaki, T., 30/06/2023, In: Clinical Trials. 20, 3, p. 261-268 8 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  13. Published

    A Comparison of Model-Free Phase I Dose Escalation Designs for Dual-Agent Combination Therapies

    Barnett, H., George, M., Skanji, D., Saint-Hilary, G., Jaki, T. & Mozgunov, P., 29/02/2024, In: Statistical Methods in Medical Research. 33, 2, p. 203-226 24 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  14. Published

    Optimization, refinement and reduction of murine in vivo experiments to assess therapeutic approaches for hemophilia A.

    Baumgartner, B., Jaki, T., Wolfsegger, M. J., Eder, B., Schiviz, A., Schwarz, H. P. & Muchitsch, E. M., 07/2010, In: Laboratory Animals. 44, 3, p. 211-217 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  15. Published

    Model-Based dose escalation Designs in R with crmPack

    Bové, D. S., Yeung, W. Y., Palermo, G. & Jaki, T., 13/06/2019, In: Journal of Statistical Software. 89, 10, 22 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  16. Published

    Understanding clinical prediction models as ‘innovations’: a mixed methods study in UK family practice

    Brown, B., Cheraghi-Sohi, S., Jaki, T. F., Su, T.-L., Buchan, I. & Sperrin, M., 9/08/2016, In: BMC Medical Informatics and Decision Making. 16, 13 p., 106.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  17. Published

    Estimation in multi-arm two-stage trials with treatment selection and time-to-event endpoint

    Brueckner, M., Titman, A. C. & Jaki, T. F., 10/09/2017, In: Statistics in Medicine. 36, 20, p. 3137-3153 17 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  18. Published

    Instrumental variable estimation in semi-parametric additive hazards models

    Brueckner, M., Titman, A. C. & Jaki, T. F., 1/03/2019, In: Biometrics. 75, 1, p. 110-120 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  19. Published

    Performance of different clinical trial designs to evaluate treatments during an epidemic

    Brueckner, M., Titman, A. C., Jaki, T. F., Rojek, A. & Horby, P. W., 11/09/2018, In: PLoS ONE. 13, 9, 19 p., e0203387.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  20. Published

    Adding flexibility to clinical trial designs: an example-based guide to the practical use of adaptive designs

    Burnett, T., Mozgunov, P., Pallmann, P., Villar, S. S., Wheeler, G. M. & Jaki, T., 19/11/2020, In: BMC Medicine. 18, 1, 21 p., 352.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  21. Published

    A permutation test for assessing the presence of individual differences in treatment effects

    Chang, C., Jaki, T., Sadiq, M. S., Kuhlemeier, A., Feaster, D., Cole, N., Lamont, A., Oberski, D., Desai, Y. & Lee Van Horn, M., 1/11/2021, In: Statistical Methods in Medical Research. 30, 11, p. 2369-2381 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  22. Published

    Design and estimation in clinical trials with subpopulation selection

    Chiu, Y.-D., Koenig, F., Posch, M. & Jaki, T. F., 20/12/2018, In: Statistics in Medicine. 37, 29, p. 4335-4352 18 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  23. Published

    A practical design for a dual-agent dose-escalation trial that incorporates pharmacokinetic data

    Cotterill, A., Lorand, D., Wang, J. & Jaki, T., 15/06/2015, In: Statistics in Medicine. 34, 13, p. 2138-2164 27 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  24. Published

    Dose-escalation strategies which utilise subgroup information

    Cotterill, A. & Jaki, T. F., 09/2018, In: Pharmaceutical Statistics. 17, 5, p. 414-436 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  25. Published

    Editorial for the MCP 2017 Special Issue

    Cui, X., Hsu, J. C. & Jaki, T., 11/01/2019, In: Biometrical Journal. 61, 1, p. 7 1 p.

    Research output: Contribution to Journal/Magazine › Editorial › peer-review

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