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A hybrid method to estimate the minimum effective dose for monotone and non-monotone dose-response relationships

Research output: Contribution to journalJournal article


  • Martin J. Wolfsegger
  • Georg Gutjahr
  • Werner Engl
  • Thomas Jaki
<mark>Journal publication date</mark>2014
Number of pages7
Early online date3/12/13
<mark>Original language</mark>English


This article proposes a new multiple-testing approach for estimation of the minimum effective dose allowing for non-monotonous dose–response shapes. The presented approach combines the advantages of two commonly used methods. It is shown that the new approach controls the error rate of underestimating the true minimum effective dose. Monte Carlo simulations indicate that the proposed method outperforms alternative methods in many cases and is only marginally worse in the remaining situations.