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A hybrid method to estimate the minimum effective dose for monotone and non-monotone dose-response relationships

Research output: Contribution to journalJournal article

Published

  • Martin J. Wolfsegger
  • Georg Gutjahr
  • Werner Engl
  • Thomas Jaki
Journal publication date2014
JournalBiometrics
Journal number1
Volume70
Number of pages7
Pages103-109
Early online date3/12/13
Original languageEnglish

Abstract

This article proposes a new multiple-testing approach for estimation of the minimum effective dose allowing for non-monotonous dose–response shapes. The presented approach combines the advantages of two commonly used methods. It is shown that the new approach controls the error rate of underestimating the true minimum effective dose. Monte Carlo simulations indicate that the proposed method outperforms alternative methods in many cases and is only marginally worse in the remaining situations.