Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - A hybrid method to estimate the minimum effective dose for monotone and non-monotone dose-response relationships
AU - Wolfsegger, Martin J.
AU - Gutjahr, Georg
AU - Engl, Werner
AU - Jaki, Thomas
PY - 2014
Y1 - 2014
N2 - This article proposes a new multiple-testing approach for estimation of the minimum effective dose allowing for non-monotonous dose–response shapes. The presented approach combines the advantages of two commonly used methods. It is shown that the new approach controls the error rate of underestimating the true minimum effective dose. Monte Carlo simulations indicate that the proposed method outperforms alternative methods in many cases and is only marginally worse in the remaining situations.
AB - This article proposes a new multiple-testing approach for estimation of the minimum effective dose allowing for non-monotonous dose–response shapes. The presented approach combines the advantages of two commonly used methods. It is shown that the new approach controls the error rate of underestimating the true minimum effective dose. Monte Carlo simulations indicate that the proposed method outperforms alternative methods in many cases and is only marginally worse in the remaining situations.
KW - Dose finding
KW - Familywise error rate
KW - Minimum effective dose
KW - Multiple comparisons
KW - Non-monotone shapes
KW - Stepwise testing procedures
U2 - 10.1111/biom.12117
DO - 10.1111/biom.12117
M3 - Journal article
VL - 70
SP - 103
EP - 109
JO - Biometrics
JF - Biometrics
SN - 0006-341X
IS - 1
ER -