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A hybrid method to estimate the minimum effective dose for monotone and non-monotone dose-response relationships

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A hybrid method to estimate the minimum effective dose for monotone and non-monotone dose-response relationships. / Wolfsegger, Martin J.; Gutjahr, Georg; Engl, Werner; Jaki, Thomas.

In: Biometrics, Vol. 70, No. 1, 2014, p. 103-109.

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Wolfsegger, Martin J. ; Gutjahr, Georg ; Engl, Werner ; Jaki, Thomas. / A hybrid method to estimate the minimum effective dose for monotone and non-monotone dose-response relationships. In: Biometrics. 2014 ; Vol. 70, No. 1. pp. 103-109.

Bibtex

@article{b2abd4f8aaab4ecab94ec7e2b336a992,
title = "A hybrid method to estimate the minimum effective dose for monotone and non-monotone dose-response relationships",
abstract = "This article proposes a new multiple-testing approach for estimation of the minimum effective dose allowing for non-monotonous dose–response shapes. The presented approach combines the advantages of two commonly used methods. It is shown that the new approach controls the error rate of underestimating the true minimum effective dose. Monte Carlo simulations indicate that the proposed method outperforms alternative methods in many cases and is only marginally worse in the remaining situations.",
keywords = "Dose finding, Familywise error rate, Minimum effective dose, Multiple comparisons, Non-monotone shapes, Stepwise testing procedures",
author = "Wolfsegger, {Martin J.} and Georg Gutjahr and Werner Engl and Thomas Jaki",
year = "2014",
doi = "10.1111/biom.12117",
language = "English",
volume = "70",
pages = "103--109",
journal = "Biometrics",
issn = "0006-341X",
publisher = "Wiley-Blackwell",
number = "1",

}

RIS

TY - JOUR

T1 - A hybrid method to estimate the minimum effective dose for monotone and non-monotone dose-response relationships

AU - Wolfsegger, Martin J.

AU - Gutjahr, Georg

AU - Engl, Werner

AU - Jaki, Thomas

PY - 2014

Y1 - 2014

N2 - This article proposes a new multiple-testing approach for estimation of the minimum effective dose allowing for non-monotonous dose–response shapes. The presented approach combines the advantages of two commonly used methods. It is shown that the new approach controls the error rate of underestimating the true minimum effective dose. Monte Carlo simulations indicate that the proposed method outperforms alternative methods in many cases and is only marginally worse in the remaining situations.

AB - This article proposes a new multiple-testing approach for estimation of the minimum effective dose allowing for non-monotonous dose–response shapes. The presented approach combines the advantages of two commonly used methods. It is shown that the new approach controls the error rate of underestimating the true minimum effective dose. Monte Carlo simulations indicate that the proposed method outperforms alternative methods in many cases and is only marginally worse in the remaining situations.

KW - Dose finding

KW - Familywise error rate

KW - Minimum effective dose

KW - Multiple comparisons

KW - Non-monotone shapes

KW - Stepwise testing procedures

U2 - 10.1111/biom.12117

DO - 10.1111/biom.12117

M3 - Journal article

VL - 70

SP - 103

EP - 109

JO - Biometrics

JF - Biometrics

SN - 0006-341X

IS - 1

ER -