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Nonequilibrium rate theory for conduction in open ion channels

Research output: Contribution to journalJournal article


Article number1240016
<mark>Journal publication date</mark>31/03/2012
<mark>Journal</mark>Fluctuation and Noise Letters
Number of pages10
<mark>Original language</mark>English


We present a nonequilibrium reaction rate model of the ionic transition through an open ion channel, taking account of the interaction between an ion at the entrance of the channel and an ion at the binding site in a self-consistent way. The electrostatic potential is calculated by solution of the Poisson equation for a channel modeled as a cylindrical tube. The transition rate, and the binding site occupancy as a function of the left bulk concentration are compared to 1D Brownian dynamics simulations. The analysis is performed for a single binding site of high-affinity, with the exit rate influenced by barrier fluctuations at the channel exit. The results are compared with experimental data for the permeation of the Na+ ion through the Gramicidin A channel, with which they are shown to be in good agreement.

Bibliographic note

Electronic version of this article published as Nonequilibrium rate theory for conduction in open ion channels in Fluctuation and Noise Letters, Volume 11, Issue 1, 2012, 10 Pages DOI : 10.1142/S0219477512400160 © copyright World Scientific Publishing Company http://www.worldscientific.com/worldscinet/fnl