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    Rights statement: Electronic version of this article published as Nonequilibrium rate theory for conduction in open ion channels in Fluctuation and Noise Letters, Volume 11, Issue 1, 2012, 10 Pages DOI : 10.1142/S0219477512400160 © copyright World Scientific Publishing Company http://www.worldscientific.com/worldscinet/fnl

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Nonequilibrium rate theory for conduction in open ion channels

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Nonequilibrium rate theory for conduction in open ion channels. / Tindjong, R.; Kaufman, I.; McClintock, P. V. E. et al.

In: Fluctuation and Noise Letters, Vol. 11, No. 1, 1240016, 31.03.2012.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

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Tindjong R, Kaufman I, McClintock PVE, Luchinsky DG, Eisenberg RS. Nonequilibrium rate theory for conduction in open ion channels. Fluctuation and Noise Letters. 2012 Mar 31;11(1):1240016. doi: 10.1142/S0219477512400160

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@article{925693cda3d94ef0808f0fea6609ae6a,
title = "Nonequilibrium rate theory for conduction in open ion channels",
abstract = "We present a nonequilibrium reaction rate model of the ionic transition through an open ion channel, taking account of the interaction between an ion at the entrance of the channel and an ion at the binding site in a self-consistent way. The electrostatic potential is calculated by solution of the Poisson equation for a channel modeled as a cylindrical tube. The transition rate, and the binding site occupancy as a function of the left bulk concentration are compared to 1D Brownian dynamics simulations. The analysis is performed for a single binding site of high-affinity, with the exit rate influenced by barrier fluctuations at the channel exit. The results are compared with experimental data for the permeation of the Na+ ion through the Gramicidin A channel, with which they are shown to be in good agreement.",
keywords = "Ion channels, permeation, nonequilibrium rate, stochastic dynamics, fluctuating barrier",
author = "R. Tindjong and I. Kaufman and McClintock, {P. V. E.} and Luchinsky, {D. G.} and Eisenberg, {R. S.}",
note = "Electronic version of this article published as Nonequilibrium rate theory for conduction in open ion channels in Fluctuation and Noise Letters, Volume 11, Issue 1, 2012, 10 Pages DOI : 10.1142/S0219477512400160 {\textcopyright} copyright World Scientific Publishing Company http://www.worldscientific.com/worldscinet/fnl",
year = "2012",
month = mar,
day = "31",
doi = "10.1142/S0219477512400160",
language = "English",
volume = "11",
journal = "Fluctuation and Noise Letters",
issn = "0219-4775",
publisher = "World Scientific Publishing Co. Pte Ltd",
number = "1",

}

RIS

TY - JOUR

T1 - Nonequilibrium rate theory for conduction in open ion channels

AU - Tindjong, R.

AU - Kaufman, I.

AU - McClintock, P. V. E.

AU - Luchinsky, D. G.

AU - Eisenberg, R. S.

N1 - Electronic version of this article published as Nonequilibrium rate theory for conduction in open ion channels in Fluctuation and Noise Letters, Volume 11, Issue 1, 2012, 10 Pages DOI : 10.1142/S0219477512400160 © copyright World Scientific Publishing Company http://www.worldscientific.com/worldscinet/fnl

PY - 2012/3/31

Y1 - 2012/3/31

N2 - We present a nonequilibrium reaction rate model of the ionic transition through an open ion channel, taking account of the interaction between an ion at the entrance of the channel and an ion at the binding site in a self-consistent way. The electrostatic potential is calculated by solution of the Poisson equation for a channel modeled as a cylindrical tube. The transition rate, and the binding site occupancy as a function of the left bulk concentration are compared to 1D Brownian dynamics simulations. The analysis is performed for a single binding site of high-affinity, with the exit rate influenced by barrier fluctuations at the channel exit. The results are compared with experimental data for the permeation of the Na+ ion through the Gramicidin A channel, with which they are shown to be in good agreement.

AB - We present a nonequilibrium reaction rate model of the ionic transition through an open ion channel, taking account of the interaction between an ion at the entrance of the channel and an ion at the binding site in a self-consistent way. The electrostatic potential is calculated by solution of the Poisson equation for a channel modeled as a cylindrical tube. The transition rate, and the binding site occupancy as a function of the left bulk concentration are compared to 1D Brownian dynamics simulations. The analysis is performed for a single binding site of high-affinity, with the exit rate influenced by barrier fluctuations at the channel exit. The results are compared with experimental data for the permeation of the Na+ ion through the Gramicidin A channel, with which they are shown to be in good agreement.

KW - Ion channels

KW - permeation

KW - nonequilibrium rate

KW - stochastic dynamics

KW - fluctuating barrier

U2 - 10.1142/S0219477512400160

DO - 10.1142/S0219477512400160

M3 - Journal article

VL - 11

JO - Fluctuation and Noise Letters

JF - Fluctuation and Noise Letters

SN - 0219-4775

IS - 1

M1 - 1240016

ER -